Clinical trials: Prolonged Weaning
Critical Illness Polyneuropathies
Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness
The researchers intend to investigate possible anabolic effects of bi-weekly exogenous testosterone administration during intensive care unit (ICU) stay for up to 8 weeks.
- Trial name
- RAS-ICU (NCT03038919)
- Testing
- Testosterone cypionate, Standard nutrition and physical therapy at ICU
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Mechanical Ventilatory Failure
Weaning From Prolonged Mechanical Ventilation
Patients requiring the use of artificial ventilation (also called mechanical ventilation) for more than 21 days account for more than 37% of all ICU costs.
- Trial name
- NCT01541462
- Testing
- Weaning
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- RML Specialty Hospital
Mechanical Ventilation Complication
Effects of Growth Hormone on Difficult Ventilator Weaning Patients
Major abdominal surgeries may be followed by postoperative pulmonary complications (PPCs). These complications are common and can cause significant morbidity and mortality.
- Trial name
- NCT03717168
- Testing
- Recombinant human growth hormone, Control
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Prolonged Mechanical Ventilation, Ventilator Weaning
Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation
This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged…
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Ventilator Dependent, Exoskeleton Device
- Trial name
- NCT07445035
- Testing
- lower-limb exoskeleton, Standard medical treatment
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Fu Jen Catholic University
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Respiratory Failure, Respiration, Artificial
Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation
A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode.
- Trial name
- NCT04140682
- Testing
- PAV+ mode, PSV mode
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Patients With Prolonged Weaning
Effects of Nasal Airflow on Sleep in Tracheotomized Patients
The passage of air through the nasal cavities generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional brain areas and is associated with better cognitive…
- Trial name
- Nasa (NCT06547463)
- Testing
- nasal oxygenation device
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
PMV
Abdominal Weight Training Assisted by Cough Assist Machine on Lung Function
The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness, making it more difficult to wean.
- Trial name
- NCT05295381
- Testing
- cough machine (CM), abdominal weight training (AWT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Liu Shih Feng
Prolonged Mechanical Ventilation, Ventilator Weaning
Standardized Tracheostomy Weaning Protocol for Prolonged Mechanical Ventilation
This study evaluated the feasibility and clinical outcomes of a standardized weaning protocol for tracheostomized patients requiring prolonged mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Tracheostomy
- Trial name
- NCT06642714
- Testing
- Standardized Stepwise Weaning Protocol
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Capital Medical University
High Flow Oxygen Therapy
Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the…
- Trial name
- NCT06357390
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
ARDS
Vitamin C Versus Nitric Oxide in Prolonged Ventilation
This a prospective double-blind study done in King Abdul-Aziz specialist hospital between January 2019 and April 2020 in the intensive care unit on 60 patients with difficult weaning and ventilated for 10 days.
- Trial name
- NCT04411160
- Testing
- Vitamin C, Nitric Oxide, ventilators
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Respiration, Artificial
Use of a New Isokinetic Device for Inspiratory Muscle Training
Introduction: It is well established that physical fitness improves muscle performance either in sedentary people or in athletes.
- Trial name
- NCT02932189
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Universidade Federal Fluminense
Prolonged Mechanical Ventilation, Critical Illness
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support.
- Trial name
- SECRET-VENT (NCT07177183)
- Testing
- Dietary supplement creatine, No intervention
- Where
- 2 sites in Czechia
- Volunteers
- 492 people
- Sponsor
- University Hospital Ostrava
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
Ventilator Weaning, Respiratory Failure
Assessments of Diaphragm-pleural Mechanics During the Weaning From Prolonged Mechanical Ventilation
Weaning failure from mechanical ventilator is commonly seen in respiratory failure and increases duration of ventilator use, ICU stay, ventilator associated pneumonia and even mortality.
- Trial name
- NCT03842280
- Testing
- Diaphragm ultrasound assessment & Esophageal pressure measurement
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Disease
Examination of Cardiovascular Function/ Cardio Respiratory Interaction on Spontaneous Breathing Trials in Patients in the Prolonged Weaning
The aim of the present study is to determine the cardiovascular function/ cardio respiratory interaction on spontaneous breathing trials in patients with prolonged weaning.
- Trial name
- Weaning TTE (NCT02569385)
- Testing
- Spontaneous breathing trial
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Ventilator Weaning
Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation
1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant.
- Trial name
- NCT03433105
- Where
- Taiwan
- Volunteers
- 157 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Weaning
Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients
This study will compare Drager Smart Care (SC), a commercially available automated ventilator controlled weaning mode to the current daily spontaneous breathing trial (SBT) weaning protocol.
- Trial name
- NCT00813839
- Testing
- daily weaning trails
- Where
- United States
- Sponsor
- University of California, San Francisco
Wounds and Injuries, Ventilation Therapy; Complications
CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
Critically ill patients often require tracheal intubation for mechanical ventilation, and timely weaning is crucial for airway management and reducing complications.
- Trial name
- NCT06339073
- Testing
- mechanical ventilation
- Where
- China
- Volunteers
- 1,023 people
- Sponsor
- Jinling Hospital, China