Clinical trials: Prophylactic
COVID-19, SARS-CoV-2
Study to Assess Safety, Reactogenicity and Immunogenicity of the repRNA(QTP104) Vaccine Against SARS-CoV-2(COVID-19)
This study is to evaluate the safety, reactogenicity, and immunogenicity of the QTP104 vaccine against SARS-CoV-2 infection in healthy adults.
- Trial name
- NCT05876364
- Testing
- QTP104 1ug, QTP104 5ug, QTP104 25ug
- Where
- 2 sites in South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Quratis Inc.
Infections, Urinary Tract, Nephrolithiasis
Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy
The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in…
- Trial name
- NCT06149455
- Testing
- Duration of antibiotics
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Delayed Onset Muscle Soreness
The Preventive Effects of Neurodynamic Mobilisation
In the study, 34 healthy sedentary male volunteers were randomly divided into two groups as NM (n = 17) and SHAM-NM (n = 17). After the initial evaluation of the individuals, femoral nerve NM and placebo NM techniques were…
- Trial name
- NCT05326893
- Testing
- Femoral nerve neurodynamic mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Uğur Sözlü
Hemophilia A
Phase 3 Study for Efficacy and Safety Outcomes Data in Japanese Patients With Severe Hemophilia A
This Phase III clinical study will evaluate the safety and effectiveness of valoctocogene roxaparvovec in Japanese patients with severe hemophilia A.
- Trial name
- GENEr8-JPN (NCT06224907)
- Testing
- Valoctocogene roxaparvovec
- Where
- 4 sites in Japan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BioMarin Pharmaceutical
Dental Plaque, Gingivitis
Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals.
The purpose of the study is to assess the effect of an enzyme containing lozenge on dental plaque accumulation in healthy adults.
- Conditions
- Dental Plaque, Gingivitis, Microbial Colonization
- Trial name
- NCT05070507
- Testing
- Enzyme containing lozenge
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Rabies, Prevention
A Study to Evaluate a PIKA Rabies Vaccine（Vero Cell）for Human Use,Freeze-dried
This is a phase III, randomized, comparator-controlled, double-blind, multicenter study to evaluate lot-to-lot consistency of three lots of a PIKA Rabies Vaccine, immunogenicity and safety in healthy adults using a post-exposure…
- Trial name
- NCT05667974
- Testing
- PIKA Rabies Vaccine (Vero Cell) for Human use, Freeze-dried, Chirorab
- Where
- 7 sites in Pakistan, Philippines
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Yisheng Biopharma (Singapore) Pte. Ltd.
Preleukemia, Myelodysplastic Neoplasm
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
- Conditions
- Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia
- Trial name
- NCT04741945
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kirsten Grønbæk
Cardiovascular Morbidity, Cardiovascular Risk Assesment
A Hospital-Based Registry of Preventive Cardiology Clinics
More research is needed to articulate the most effective ways to use these tools as screening tests in cardiovascular risk assessments and how they ultimately affect CVD mortality and morbidity outcomes.
- Conditions
- Cardiovascular Morbidity, Cardiovascular Risk Assesment, Primary Prevention CVD
- Trial name
- PREVENT-CARD (NCT06503341)
- Testing
- Cardiovascular risk assesment
- Where
- Pakistan
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Adolescent Futsal Players
Preventive Exercise Program for Adolescent Futsal Players.
The main aim of this study is to analyse the effect of a preventive exercise program (INSPIRE: Indoor Sports Injury Prevention) on the lower-limb injuries in adolescent futsal players.
- Trial name
- INSPIRE (NCT07648186)
- Testing
- Exercise, Standard Care (in control arm)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Incisional Hernia, Aortic Aneurysm
Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair
The goal of this retrospective observational study is to evaluate whether prophylactic mesh reinforcement during abdominal wall closure can prevent incisional hernias (IH) in patients undergoing open abdominal aortic aneurysm…
- Trial name
- NCT06762561
- Testing
- Prophylactic retromuscular mesh reinforcement
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hôpital Fribourgeois
Malaria
Pharmacokinetics of Sulfadoxine-pyrimethamine Plus Amodiaquine for Intermittent Preventive Treatment in Children (IPTc)
The aim of the study is to determine the pharmacokinetic profile of sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ) when used for seasonal Intermittent Preventive Treatment (IPT) to prevent malaria in children aged 3 to 59…
- Trial name
- NCT01328990
- Testing
- sulfadoxine-pyrimethamine plus amodiaquine
- Where
- Senegal
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Pain, Postoperative
Does Preventive Dexketoprofen Reduce Pain After Orthognathic Surgery
Background The purpose of this study was to evaluate the effect of a single-dose intravenous dexketoprofen administration for preventive analgesia on postoperative pain and reducing swelling in double jaw surgery.
- Trial name
- NCT05303688
- Testing
- iv dexketoprofen trometamol (Arveles 50mg/2mL; UFSA, İstanbul, Turkey), Steril Salin (control)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pain
Effects of Prophylactic Massage Therapy on Pain Tolerance and Threshold
Therapeutic massage has been thought to reduce anxiety and increase relaxation in human patients.This study is meant to determine the immediate effects of therapeutic massage on pain tolerance and threshold.
- Trial name
- NCT04625335
- Testing
- No Massage Protocol, Prophylactic Therapeutic Massage
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Kyle Knight
Mental Health Wellness 1, Mental Disorders
Impact of PAX Good Behavior Game on Elementary School Students in Estonia
The aim of this study is to measure the impact of the intervention (PAX GBG) in Estonian-language 1st grade classrooms on students' mental health and behaviour, and teacher's self-efficacy.
- Trial name
- PAXGBGEE (NCT02865603)
- Testing
- PAX Good Behavior Game
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- National Institute for Health Development, Estonia
Pit and Fissure Sealant
Retention Rate and Caries Preventive Effect of Preheated Flowable Resin Composite Used as a Pit and Fissure Sealant
Retention rate and caries preventive effect of preheated flowable resin composite used as a pit and fissure sealant versus conventional resin-based fissure sealant in patients with permanent molars with deep pit and fissure over…
- Trial name
- NCT05606874
- Testing
- Pre-heating of flowable resin composite used as a pit and fissure sealant., Conventional resin fissure sealant
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Health Behavior, Health-Related Behavior
Preventive Remediation for OptiMal StudentS (PROMESS-Group)
Health students exhibit excessive sedentary behavior, elevated stress levels, and significant sleep disturbances, all of which contribute to a decline in their overall health, quality of life, and learning capacities.
- Trial name
- PROMESS-Group (NCT07030751)
- Testing
- Stress management, sleep improvement and fatigue reduction, sedentary behaviors reduction and physical activity promotion.
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Research on Healthcare Performance Lab U1290
HIV Infections
Safety of and Immune Response to an HIV-1 DNA Vaccine (VRC HIVDNA009-00-VP) in HIV Uninfected Adults
The purpose of this study is to test the safety of and immune response to an HIV-1 vaccine, VRC-HIVDNA009-00-VP, in HIV uninfected participants. Two different doses of the vaccine will be tested.
- Trial name
- NCT00071851
- Testing
- VRC-HIVDNA009-00-VP
- Where
- 14 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Carotid Artery Atheroma, Cardiovascular Risk Stratification
Randomized Controlled Trial on Carotid Atherosclerosis Screening in Asymptomatic Smokers and Hypertensive Adults: Prevalence and Impact on Cardiovascular Prevention
Title of the study: Carotid Atherosclerosis Screening: Epidemiological Profile and Preventive Intervention. Objective: The main objective of this study is to characterize and identify the prevalence of carotid atherosclerosis in…
- Trial name
- CAROTID-CARE (NCT06848283)
- Testing
- Carotid ultrasonography
- Volunteers
- 4,780 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Human Papillomavirus-Related Carcinoma
Recombinant Human Papillomavirus Nonavalent Vaccine in Preventing Human Papilloma Virus in Younger Healthy Participants
Human papillomavirus (HPV) is a common sexually-transmitted virus which causes infections that usually last only a few months, but sometimes can last a long time and cause cancers of the cervix, vagina, vulva, anus or oropharynx…
- Trial name
- NCT02568566
- Testing
- Laboratory Biomarker Analysis, Recombinant Human Papillomavirus Nonavalent Vaccine
- Where
- 2 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Kidney Injury, Kidney Disease, Chronic
Early Diagnosis of Kidney Damage Associated With Tobacco Use
Tobacco consumption is associated with the appearance of several pathologies, the best known are Chronic Obstructive Pulmonary Disease, several types of cancer and cardiovascular diseases.
- Conditions
- Kidney Injury, Kidney Disease, Chronic, Tobacco Toxicity
- Trial name
- NCT03850756
- Testing
- Early kidney damage biomarkers, Predisposition to kidney injury biomarkers, Tobacco consumption
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León