Clinical trials: Prophylaxis of Deep Vein Thrombosis
Venous Thrombosis, Pulmonary Embolism
Extended Out-of-hospital Low-molecular-weight Heparin Prophylaxis Against DVT and PE in Patients Undergoing Major Lung Resection
Postoperative venous thromboembolism (VTE) is a significant health-care problem, resulting in significant morbidity, mortality and resource utilization. The true incidence is unknown, and may range from 1% to 15%.
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Lung Neoplasms
- Trial name
- NCT02258958
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McMaster University
Venous Thromboembolism
RE-COVERY DVT/PE: Global Study on Treatment Secondary Prevention of Acute Venous Thromboembolism
RE-COVERY is a large, multi-national, multi-center observational study based on new data collection. The study will enroll and characterize patients within 30 days of being diagnosed with an acute DVT and/or PE.
- Trial name
- NCT02596230
- Where
- 222 sites in United States, Argentina and 35 more
- Volunteers
- 7,797 people
- Sponsor
- Boehringer Ingelheim
Prevention, Venous Thromboembolism
A Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty
The objective of this study is to assess the efficacy and safety of DU-176b compared with enoxaparin sodium for the prevention of venous thromboembolism in patients after elective total hip arthroplasty.
- Trial name
- NCT01181167
- Testing
- edoxaban, enoxaparin sodium
- Where
- 2 sites in Japan
- Volunteers
- 610 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
May-Thurner Syndrome
Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban for the prevention of deep vein thrombosis in patients with left iliac vein compression treated with stent implantation.
- Trial name
- PLICTS (NCT04067505)
- Testing
- Rivaroxaban, Warfarin, Nadroparin
- Where
- 9 sites in China
- Volunteers
- 224 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostate Cancer, Venous Thromboembolism
PREvention of VENous ThromboEmbolism Following Radical Prostatectomy
The PREVENTER Trial aims to compare the use of perioperative pharmacologic prophylaxis (subcutaneous heparin) with intermittent pneumatic compression devices (IPCs) to the use of IPCs alone for the prevention of venous…
- Conditions
- Prostate Cancer, Venous Thromboembolism, Lymphocele After Surgical Procedure, Deep Venous Thrombosis
- Trial name
- PREVENTER (NCT03006562)
- Testing
- Subcutaneous Heparin
- Where
- United States
- Volunteers
- 501 people
- Sponsor
- Johns Hopkins University
Thrombosis, Venous
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
The purpose of this study is to evaluate the efficacy and safety of fondaparinux in comparison with a heparin (nadroparin) in preventing deep vein thrombosis (blood clots in the leg veins), whether symptomatic or detected by…
- Trial name
- FONDACAST (NCT00843492)
- Testing
- Fondaparinux sodium, Nadroparin
- Where
- 122 sites in France, Germany and 4 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis
This Research Proposal Focuses on Evaluating the Effectiveness of a Nursing Care Protocol in Preventing Deep Vein Thrombosis (DVT) in Patients Undergoing On-pump Cardiac Surgery. The Study Will Include an Intervention Group That Receives the Nursing Protocol and a Control Group That Receives Routine
The primary focus of this research proposal is to examine the efficacy of a nursing care protocol in preventing the occurrence of deep vein thrombosis (DVT) in patients undergoing on-pump cardiac surgery.
- Conditions
- On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis, DVT Prophylaxis, DVT Prevention
- Trial name
- DVT (NCT07347652)
- Testing
- IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.
- Where
- Cyprus
- Volunteers
- 67 people
- Sponsor
- Near East University, Turkey
Venous Thromboembolism
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
The primary objective of the study is to evaluate the efficacy of REGN9933 for the prevention of venous thromboembolism (VTE) after unilateral total knee arthroplasty (TKA), compared to enoxaparin The secondary objectives of the…
- Trial name
- NCT05618808
- Testing
- REGN9933, Enoxaparin, Apixiban
- Where
- 16 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 373 people
- Sponsor
- Regeneron Pharmaceuticals
Venous Thromboembolism, Total Hip Arthroplasty (THA)
The Effect of a VTE Prevention Care Bundle in Total Hip Arthroplasty Patients
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a critical and potentially life-threatening complication following total hip arthroplasty (THA).
- Conditions
- Venous Thromboembolism, Total Hip Arthroplasty (THA), Deep Vein Thrombosis
- Trial name
- VTE-CARE-THA (NCT07702903)
- Testing
- VTE Prevention Care Bundle, Standard Routine Care
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Murat Erten
Venous Thrombosis, Pulmonary Embolism
Investigation Into the Therapeutic Dosage of Fondaparinux Sodium, a Medication Used to Prevent Blood Clots in Morbidly Obese Volunteers
Morbidly obese individuals are at high risk for potentially life threatening blood clots around the time of abdominal surgical procedures.
- Trial name
- NCT00436787
- Testing
- Fondaparinux Sodium
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Pittsburgh
Venous Thromboembolism, Deep Vein Thrombosis (DVT)
Effectiveness and Cost-effectiveness of VTE Prevention Strategies in Gynecological Surgery
Venous thromboembolism (VTE) is a highly preventable but potentially fatal complication following gynecological surgery. The Caprini risk assessment model is widely used, but real-world evidence evaluating the net clinical…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Gynecological Surgery
- Trial name
- NCT07455253
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Prevention of Stroke or Systemic Embolism, Deep Vein Thrombosis (DVT)
To Compare and Evaluate the Oral Bioavailability of Edoxaban 60 mg Film Coated Tablet With That of Lixiana® 60 mg Filmtabletten (Film Coated Tablet) (Edoxaban) in Healthy, Adult, Human Subjects Under Fasting Conditions
To compare and evaluate the oral bioavailability of Edoxaban 60 mg Film Coated Tablet with that of Lixiana® 60 mg filmtabletten (Film Coated Tablet (Edoxaban) in healthy, adult, human subjects under fasting conditions.
- Conditions
- Prevention of Stroke or Systemic Embolism, Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE)
- Trial name
- NCT06930937
- Testing
- Lixiana® Film Coated Tablet, Edoxaban Film Coated Tablet
- Where
- India
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Venous Thrombosis Deep (Limbs), Surgical Blood Loss
Pre-operative Enoxaparin in the Surgical Management of Multi-trauma Patients Undergoing Orthopedic Surgical Procedures
All trauma patients receive Lovenox or other prophylactic medication to prevent deep vein clots from forming. For the trauma patients with orthopedic injuries requiring surgery there is controversy over safety and efficacy when…
- Trial name
- NCT05081375
- Testing
- Enoxaparin Injectable Product, Sodium chloride
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Valleywise Health
COVID, Thrombosis
Weight-Adjusted vs Fixed Low Doses of Low Molecular Weight Heparin For Venous Thromboembolism Prevention in COVID-19
Worldwide observational studies indicate a significant prothrombogenic effect associated with SARS-CoV-2 infection with a high incidence of venous thromboembolism (VTE), notably life-threatening pulmonary embolism.
- Conditions
- COVID, Thrombosis, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- COVI-DOSE (NCT04373707)
- Testing
- Enoxaparin
- Where
- 17 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Central Hospital, Nancy, France
Deep-Vein Thrombosis, Pulmonary Embolism
VITRO-Trial. B Vitamins and the Secondary Prevention of Venous Thrombosis
The VITRO (Vitamins and Thrombosis) study investigated the effect of homocysteine lowering by daily supplementation of B-vitamins on the risk reduction of deep-vein thrombosis and pulmonary embolism.
- Trial name
- NCT00314990
- Testing
- 5 mg folic acid, 50 mg pyridoxine and 0.4 mg cyanocobalamin
- Where
- Netherlands
- Volunteers
- 620 people
- Sponsor
- Radboud University Medical Center
COVID-19
Effect of Anticoagulation Therapy on Clinical Outcomes in COVID-19
Patients with moderate to severe COVID-19 present a very high risk of thromboembolic disease.This multicenter, prospective, randomized, event-driven study evaluates rivaroxaban compared with standard of care with…
- Trial name
- COVID-PREVENT (NCT04416048)
- Testing
- Rivaroxaban, Standard Of Care (SOC)
- Where
- 24 sites in Germany
- Volunteers
- 111 people
- Sponsor
- Charite University, Berlin, Germany
Deep Vein Thrombosis, Pulmonary Embolism
Extended-Duration Low-Intensity Apixaban to Prevent Recurrence in High-Risk Patients With Provoked Venous Thromboembolism
Design: U.S.-based, single-center, randomized placebo-controlled trial. Brief Treatment Description: Low-intensity apixaban (2.5mg twice daily) for extended-duration secondary prevention of VTE after initial treatment for…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- HI-PRO (NCT04168203)
- Testing
- Apixaban 2.5 MG
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Brigham and Women's Hospital
Venous Thrombosis
Study of Arixtra (Fondaparinux Sodium) to Prevent Blood Clots in Women Undergoing Abdominopelvic Surgery for Likely Gynecologic Malignancy
This is a randomized trial to compare intermittent compression devices with or without post-operative Arixtra (fondaparinux sodium) in women undergoing major abdominal surgery for known or presumed gynecologic malignancies.
- Trial name
- NCT00539942
- Testing
- Arixtra (fondaparinux sodium), Intermittent compression devices (ICD)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Medical Patient, Thrombocytopenia
Thromboprophylaxis of Venous Thromboembolism in Acutely-ill Medical Inpatients With Thrombocytopenia
Fondaparinux is a parenteral anticoagulant drug approved for the prophylaxis of venous thromboembolism in high risk medical patients.
- Trial name
- FAITH (NCT01727401)
- Testing
- Fondaparinux
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- G. d'Annunzio University
Cancer Patients With Acute Lower Limb Deep Vein Thrombosis (DVT)
Mechanical Thrombectomy for Acute Lower Limb Deep Vein Thrombosis in Tumor Patients
This study will conduct a prospective single blind controlled study on the clinical efficacy and safety indicators of 50 cancer patients with acute lower limb deep vein thrombosis (DVT).
- Trial name
- NCT06085495
- Testing
- mechanical thrombectomy (PMT)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- RenJi Hospital