Clinical trials: Propionibacterium Acnes
Shoulder Arthroplasty
The Effect of Pretreatment for Propionibacterium Acnes on Surgical Site Burden in Shoulder Arthroplasty
Cutibacterium acnes - formally known as Propionibacter acnes (P. acnes) is the most common pathogen associated with prosthetic joint infection of the shoulder. Despite current skin preparation techniques, P.
- Trial name
- NCT04112407
- Testing
- Blue Light Phototherapy, Benzyl Peroxide, Control
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Albany Medical College
Eczema
Impact of a Daily Application of an Omega-3 Monoglycerides Based Serum and Cream on the Skin Microbiota
This exploratory study aims to investigate the prebiotic potential of daily application of an omega-3 serum and cream to skin affected by eczema. The study will also collect data on any potential adverse effects of the products.
- Trial name
- COS-PBP-03 (NCT07583121)
- Testing
- Omega-3 monoglyceride based topical treatment
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- SCF Pharma
Acne
Evaluation and Detection of Facial Propionibacterium Acnes Bacteria and Phage
This multi-center, outpatient study will extract and evaluate the presence of facial P. acnes bacteria and phage strains using pore strips on up to 400 human subjects.
- Trial name
- NCT03009903
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MBcure Ltd
Back Pain, Low, Degenerative Disc Disease
Protocol for an Analytical Study With Microbiological, Phenotypic, Genotypic and Multiomics Techniques
The study aims to identify metabolites present in intervertebral discs colonized by C. acnes from patients with low back pain and degenerative disc disease, correlating them with their clinical, radiological and demographic…
- Trial name
- NCT05090553
- Testing
- Lumbar Spinal Fusion Surgery, Bacterial culture, Phenotypic and genotypic characterization
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Gaffree & Guinle Universitary Hospital
Infection
The Incidence and Incubation Period of False Positive Cultures in Shoulder Surgery
This study will describe the time point at which a positive culture from a patient who has undergone shoulder surgery should be treated as an infection versus a false positive result that should be disregarded.
- Trial name
- NCT02602548
- Testing
- Culture
- Volunteers
- 100 people
- Sponsor
- Forte Sports Medicine and Orthopedics
Acne Vulgaris
A Phase 1 Study Evaluating Safety and Tolerability of NVN1000 Gel
This is a 2 week Phase 1 study of SB204 (NVN1000 Gel) in healthy adult volunteers with elevated Propionibacterium acnes (P. acnes) counts. Subjects will apply NVN1000 4% Gel or Vehicle Gel twice daily to their face.
- Trial name
- NCT01844739
- Testing
- NVN1000 4% Gel, Vehicle Gel
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Novan, Inc.
Lumbar Disc Herniation, Lumbar Disc Degeneration
The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease
The goal of this study is to clarify the role of the bacterium Cutibacterium acnes in the development of degenerative disc disease in patients with lumbar disc herniation who underwent microdiscectomy as part of their regular…
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Degeneration, Cutibacterium Acnes, Low Back Pain
- Trial name
- NCT07085247
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Masaryk University
Acne Vulgaris
Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel
The purpose of this study is to evaluate the antibacterial activity of Epiduo® Gel (Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel) on P. acnes compared to that of Benzoyl Peroxide 2.5% Gel.
- Trial name
- NCT01188538
- Testing
- Epiduo gel, BPO
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Galderma R&D
Prosthetic-joint Infection
Benzoyl Peroxide and Electrocautery Skin Incision to Eradicate Cutibacterium Acnes
The goal of this prospective randomized clinical trial is to investigate the potential synergistic effect of combination of topical benzoyl peroxide and making skin incision with electrocautery on preventing surgical wound…
- Trial name
- NCT05676411
- Testing
- Benzoyl Peroxide Topical, Electrocautery surgical skin incision
- Where
- United States
- Sponsor
- University of Missouri-Columbia
P Acnes Colonization
Evaluate Effectiveness of Epiduo® Gel in Reducing Antibiotic Sensitive & Resistant Strains of Propionibacterium (P)Acnes
The purpose of this study is to evaluate the effectiveness of Epiduo® Gel in reducing antibiotic sensitive and resistant strains of P acnes in vivo.
- Trial name
- NCT00907101
- Testing
- Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel (Epiduo® Gel)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Galderma R&D
Sarcoidosis, Pulmonary, Sarcoidosis Skin
the PHENOSAR Trial: Use of Antibiotics in Treatment of Sarcoidosis
In this study it is investigated whether treatment with azithromycin in combination with doxycycline reduces the bacterial load of C.
- Trial name
- NCT05291468
- Testing
- FDG-PET/CT
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- St. Antonius Hospital
Post-Operative Wound Infection, Surgical Site Infection
Cutibacterium Acnes: Triple Prevention in Shoulder Operations
Patients planned for shoulder surgery will be identified and contacted for participation. After informed consent is provided, patients will be randomised into one of three groups: pre-operative cutaneous disinfection with iodine…
- Trial name
- C3PO (NCT05701475)
- Testing
- Subcutaneous disinfection, Benzoyl peroxide preparation
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Clinique Générale dAnnecy
Prosthesis Related Infection
Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: A Retrospective Cohort Study
Studies on sonication suffer from a heterogeneity which makes their analysis complex, due to the absence of a gold standard allowing positive cases to be defined unequivocally.
- Trial name
- SonicHUS (NCT05867108)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Acne Vulgaris
Comparison of Efficacy and Safety of Azelaic Acid 15% Gel With Its Vehicle in Subjects With Mild to Moderate Acne
Comparison of efficacy and safety of Azelaic Acid 15% gel with its vehicle in male and female patients with mild to moderate acne. Qualified subjects will apply the gel to their face twice a day for a period of 12 weeks.
- Trial name
- NCT00031096
- Testing
- Azelaic Acid Gel 15% (Finacea, BAY39-6251), Vehicle gel (SH H 655 PBA)
- Where
- 16 sites in United States
- Volunteers
- 879 people
- Sponsor
- LEO Pharma
C. Acnes, Phototherapy
Photodynamic Therapy for Cutibacterium Acnes (C. Acnes) Decolonization of the Shoulder Dermis
This is a prospective, randomized controlled trial to evaluation the ability of 5-aminolevulinic acid HCL topical solution photodynamic therapy to decrease the colonization of Cutibacterium acnes (C.
- Conditions
- C. Acnes, Phototherapy, Postoperative Infection, Arthroscopic Rotator Cuff Repair
- Trial name
- NCT04636242
- Testing
- Skin Biopsy, 5 Aminolevulinic Acid + Phototherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Bone and Joint Infection
Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR
Osteaoarticular infection due to C. acnes are known to be of late onset, causing chronic infection possibly pauci-symptomatic. Osteaoarticular infection due to C. acnes represents a diagnostic challenge, since C.
- Trial name
- NCT03850548
- Testing
- Prosthetic joint infection with Cutibacterium acnes
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Hospices Civils de Lyon
Shoulder Arthroplasty, Positive C. Acnes Culture
Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty
The purpose of this randomized controlled trial is to determine the effect of post-incision wash using various novel antimicrobial solutions on the rate of positive C.
- Trial name
- NCT06831422
- Testing
- Povidone-Iodine, Hydrogen Peroxide, Xperience Antimicrobial Wash
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Infection, Bacterial
Efficacy of Surgical Diathermy in Eradicating Cutibacterium Acnes From Surgical Skin Incision During Shoulder Arthroplasty
Periprosthetic infection following shoulder arthroplasty is a devastating complication. Diagnosing and treating periprosthetic shoulder infection poses a significant challenge.
- Trial name
- Electrocautery (NCT04608916)
- Testing
- Using surgical diathermy to make skin incision, Using scalpel blade to make skin incision
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Missouri-Columbia
Acne Vulgaris, Acne
Safety and Efficacy of MBI 226 2.5% and 5.0% Topical Acne Solutions in the Treatment of Acne
This study investigates the safety and efficacy of MBI 226 2.5% and 5.0% Acne Solutions, applied topically for six weeks, in the treatment of acne.
- Conditions
- Acne Vulgaris, Acne, Propionibacterium Acnes
- Trial name
- NCT00211523
- Testing
- MBI 226 Acne Solutions
- Volunteers
- 75 people
- Sponsor
- BioWest Therapeutics Inc
Osteoarthritis
Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
The purpose of this study is to investigate antibiotic treatment to target bacteria about the shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder surgeries and is thought to contribute to…
- Trial name
- NCT03115177
- Testing
- Doxycycline, Cefazolin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Rush University Medical Center