Clinical trials: Propofol Dosage
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Lidocaine, Injection Pain
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides
Propofol is widely used in general anesthesia induction, but the occurrence of peripheral intravenous pain is relatively high, causing anxiety, fear and other adverse emotions in patients , aggravating the stress response, and…
- Trial name
- NCT04008433
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Propofol Adverse Reaction, Anesthesia
Impact of Propofol Reduction in Anesthesia Induction
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.
- Trial name
- NCT04194151
- Testing
- Propofol Injection
- Where
- Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Anesthesia, Ringer's Lactate
Ringer Lactate Preloading on Induction Dose Requirement of Propofol
To compare the effect (heart rate and mean arterial pressure) of Ringer Lactate preloading and without preloading on induction dose requirement of Propofol.
- Trial name
- NCT05777135
- Testing
- Ringer Lactate prior to surgery and Propofol
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Medical College Birgunj
Healthy
Bioequivalence Study of Propofol Medium and Long Chain Fat Emulsion Injection in Healthy Chinese Subjects
This study assessed the bioequivalence and safety of a single dose of Propofol Medium/Long Chain Fat Emulsion Injection (Test product, Haisco Pharmaceutical Group Co., Ltd.) compared to the reference product (Propofol Medium/Long…
- Trial name
- NCT07057609
- Testing
- Tested Propofol Medium and Long Chain Fat Emulsion Injection (T), Reference Propofol Medium and Long Chain Fat Emulsion Injection (R)
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Anesthesiology, Anesthesiology Management
Machine Learning-Based Model for Individualized Drug Dose Prediction for Propofol
The goal of this observational study is to develop an individualized prediction model for drug dosage during propofol-induced loss of consciousness in anticipation of advances in research in this area.
- Trial name
- NCT06703879
- Testing
- Anesthesia induction with propofol
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Gender, Anesthesia
Dosage of Propofol Based on Lean Body Weight
Patients who will be anesthesia induced with propofol will be body analyzed with Tanita before the operation. Height, weight, age, gender and other general information of the patients will be recorded.
- Trial name
- NCT06018623
- Testing
- It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Inonu University
Emergence Agitation
Prevention of Emergence Agitation in Rhinoplasty With Subanesthetic Propofol and Single-Dose Dexmedetomidine: A Prospective Double-Blind Clinical Study
To compare of prevention of emergence agitation in rhinoplasty with subanesthetic propofol and single dose dexmedetomidine
- Trial name
- NCT07144007
- Testing
- Dexmedetomidine, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Anesthesia
Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis
Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled.
- Trial name
- NCT03283410
- Testing
- Propofol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brasilia University Hospital
Healthy Subjects
Pilot Study of Bioequivalence of Cudafol(R) and Diprivan(R) Administered as Single Intravenous Doses in Healthy Subjects
Evaluate pharmacokinetic/pharmacodynamic equivalence and safety and tolerability of single doses of Cudafol(R) and Diprivan(R) in healthy subjects.
- Trial name
- NCT02713802
- Testing
- Cudafol(R) (propofol, 1% [10 mg/mL]), Diprivan(R) (propofol, 1% [10 mg/mL])
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cuda Anesthetics, LLC
Anesthesia
A Study to Evaluate the Differences in Pharmadynamics, Pharmacokinetics, and Safety Between Ciprofol and Propofol
This is a single-center, open-label, randomized, two-stage, two-way crossover Phase I study in healthy male subjects.The main objective is to evaluate the differences in pharmadynamics (PD), pharmacokinetics (PK), and safety…
- Trial name
- NCT04294056
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Anesthesia, General, Laparoscopic Surgery
Effect of Preoperative Pregabalin on Propofol Induction Dose
The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia.
- Trial name
- NCT01158859
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Hemodynamic Effects of Propofol
Hemodynamic Effects of a High Dose Versus Low Dose Propofol During Induction of Anesthesia.
The investigators will test the hemodynamic effects of a high dose versus low dose Propofol during induction of anesthesia.
- Trial name
- NCT06651749
- Testing
- Propofol injection
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Propofol Pharmacokinetics
Propofol Pharmacokinetics in Children After Single Bolus Dose
The principle objective of this study is to evaluate pharmacokinetics of propofol after single iv bolus dose in 12 Indian children and to develop a simple pharmacokinetic model of propofol.
- Trial name
- NCT02303223
- Testing
- Propofol
- Where
- India
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Anesthesia
Different Dose of Esketamine Inhibiting Response to Laryngeal Mask Airway Insertion
Objective To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
- Trial name
- NCT06370130
- Testing
- Esketamine 0.2mg/kg, Esketamine 0.3mg/kg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Aerospace Center Hospital
Hypothyroidism, Anesthesia, General
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Introduction: GABAergic synaptic transmigration in the anterior cingulate (ACC) cortex of hypothyroid rats has been demonstrated by electrophysiologic recordings.
- Conditions
- Hypothyroidism, Anesthesia, General, Propofol Dosage, Magnetic Resonance Imaging (MRI)
- Trial name
- BrainGABA (NCT06649318)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Pain, Anesthesia
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
Purpose: 1. To determine the efficacy of low-dose esketamine in painless gastrointestinal endoscopy. 2. To determine the safety of low-dose esketamine in painless gastrointestinal endoscopy. 3.
- Trial name
- NCT04691076
- Testing
- Propofol, Esketamine, Fentanyl
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Union Medical Center
Anesthesia
Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application
Cystoscopy is a simple, effective and reliable method in current urological practice. Anesthesia may be required in cystoscopy for therapeutic purpose, however it may not be necessary for diagnostic cystoscopy.
- Trial name
- NCT03424356
- Testing
- Rocuronium Bromide, Saline Solution, Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Esketamine, Loop Electrosurgical Excision
Anesthesia for Loop Electrosurgical Excision Procedure (LEEP).
The goal of this prospective, randomized controlled study study is to investigate the efficacy and safety of propofol combined with different doses of esketamine (ESK) for anesthesia during loop electrosurgical excision procedure…
- Conditions
- Esketamine, Loop Electrosurgical Excision, Propofol
- Trial name
- ESK，LEEP (NCT06574945)
- Testing
- intravenous injection of propofol only, intravenous injection of propofol +esketamine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Qian Wu
Anesthesia
A PK/PD Study of Fospropofol Disodium Compared With Propofol Injectable Emulsion
This study is designed to characterize the pharmacokinetic and pharmacodynamic effect of fospropofol disodium in comparison to propofol.
- Trial name
- NCT01260142
- Testing
- Fospropofol disodium, propofol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.