Clinical trials: Propofol Pharmacodynamics
Obesity
Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response
The aim of this study is to characterize the Pharmacokinetic/Pharmacodynamic relationship of a single bolus dose of propofol in obese patients and to extract a time to peak effect (t-peak) from the estimated model parameters.
- Trial name
- NCT01665079
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
General Anesthesia
Exploratory Study of Propofol and Fentanyl Pharmacodynamics
Exploration of the hypothesis that general anesthesia is not a singular threshold but is a continuum of central nervous system depression dependent on interpretation of nociceptive stimuli.
- Trial name
- NCT01550770
- Testing
- propofol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ethicon Endo-Surgery
Pharmacodynamic Interaction
Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia
The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).
- Trial name
- PIPDIA (NCT02777619)
- Testing
- 0.0ng/ml Dexmedetomidine, 0.4ng/ml Dexmedetomidine, 0.6ng/ml Dexmedetomidine
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Anesthesia
Pharmacokinetic/Pharmacodynamic Model of Propofol in Children
By measuring plasmatic concentration of propofol at different intervals during surgery of children aged 1 to 12 years old and measuring Bispectral Index (BIS) as a surrogate for cerebral activity, the investigators aim to create…
- Trial name
- NCT02544854
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Propofol Overdose of Undetermined Intent
Performance Evaluation of Four Pharmacokinetic-Pharmacodynamic(PKPD) Models of Propofol in Elderly Patients
Despite the wide use of propofol target-controlled infusion (TCI) in elderly patients, pharmacokinetic (PK) and pharmacodynamic (PD) models performance has not been prospectively assessed in this population.
- Trial name
- TCIGeriatric (NCT01435785)
- Where
- 2 sites in Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Anesthesia
A PK/PD Study of Fospropofol Disodium Compared With Propofol Injectable Emulsion
This study is designed to characterize the pharmacokinetic and pharmacodynamic effect of fospropofol disodium in comparison to propofol.
- Trial name
- NCT01260142
- Testing
- Fospropofol disodium, propofol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Deep Sedation
Prospective Validation of the Eleveld Model of Propofol for Procedural Sedation in Adults.
The goal of this prospective observational study is to identify effect site concentrations (CET) of propofol using the Eleveld model for different levels of procedural sedation.
- Trial name
- NCT06325033
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
General Anesthesia, Propofol Pharmacodynamics
Neuronal Inertia in Propofol Anesthesia
Loss and recovery of consciousness during propofol anesthesia seem to be mediated by different mechanisms beyond the actual effect-site concentration of anesthetic drug.
- Conditions
- General Anesthesia, Propofol Pharmacodynamics, Propofol Target Controlled Infusion, Loss of Consciousness and Recovery of Consciousness
- Trial name
- INERTIA (NCT01962285)
- Testing
- propofol targel controlled infusion
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Monitored Anesthesia Care
A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion
The purpose of this study is to explore the pharmacokinetics (PK) and pharmacodynamics (PD) of LUSEDRA® administered as a continuous infusion or bolus compared with continuous infusion of propofol injectable emulsion.
- Trial name
- NCT01308541
- Testing
- arm 1, LUSEDRA, Propofol (arm 3)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Healthy Volunteers
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of KL0011034 Injection Administered by Continuous Infusion in Healthy Adult Subjects
This study is a randomized, double-blind, propofol position-controlled trial, evaluating the safety, tolerability, and pharmacodynamic of continuous infusion of KL0011034 injection compared with propofol injectable emulsion for…
- Trial name
- NCT07828470
- Testing
- KL0011034 injection, propofol injectable emulsion
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hunan Kelun Pharmaceutical Co., Ltd.
Healthy
the Effect Site Equilibration Time of Propofol is Age Dependant
This study obtains an effect site model for White (Modified Marsh) pharmacokinetic propofol model. The plasma effect-site rate constant (ke0) obtained is affected by age.
- Trial name
- ke0agedep (NCT01586013)
- Testing
- evaluation of propofol effect using BIS
- Where
- Chile
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Morbid Obesity
Population PK/PD of Propofol in the Morbidly Obese Patient
Rationale: The extreme increase of obesity in the last years had led to this study. There is no consensus about how to anaesthetise morbidly obese patients.
- Trial name
- NCT00395681
- Testing
- Diprivan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Anesthesia, Burned
Development of pk/pd Model of Propofol in Patients With Severe Burns
Burn injuries are a prevalent problem. Actually, in Chile the Ministry of Health has recorded 6435 hospital burns and has reported 569 deaths from this cause.
- Conditions
- Anesthesia, Burned, Operative Wound
- Trial name
- HUAPQ (NCT03704285)
- Testing
- Propofol, BIS
- Where
- Chile
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Victor Contreras, MSN
Obesity
Validation of a Pharmacokinetic Pharmacodynamic Model to Administer Propofol in Obese Patients
The purpose of this study is to validate an integrated pharmacokinetic-pharmacodynamic model to administer propofol in obese patients.
- Trial name
- NCT01596387
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Healthy
Population Pharmacokinetics/Pharmacodynamics (PK/PD) of Microemulsion Propofol in Healthy Volunteers
AquafolTM (Daewon Pharmaceutical Co., Ltd., Seoul, Korea) is a microemulsion propofol that has been developed for eliminating lipid solvent-related adverse events of long chain triglyceride emulsion (LCT) propofol (Diprivan®…
- Trial name
- NCT00908726
- Testing
- propofol
- Where
- South Korea
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Propofol, Child
Time to Peak Effect of Propofol in Children
In order to determine the speed of onset of the anaesthetic propofol in children, investigators will compare the two age groups 1-6 years vs 8-13 years.
- Trial name
- TPEPC (NCT03426462)
- Testing
- Propofol
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland