Clinical trials: Prospective Studies
Depression, Dementia
Prognosis of Depression in the Elderly (PRODE). A Multicentre, Longitudinal Study of Elderly Depressed Patients.
PRODE is a Norwegian multicentre study investigating the prognosis of depression in the elderly. The study has included 169 patients who will be followed with assessments after one and three years.
- Trial name
- PRODE (NCT01952366)
- Where
- Norway
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Sykehuset Innlandet HF
Burnout Syndrome, Depression Disorder
The COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine
Introduction. Switzerland, like most Western countries, faces a paradox: an ageing, multimorbid population needs general internal medicine (GIM) physicians more than ever, yet fewer young doctors choose - and stay in - the…
- Conditions
- Burnout Syndrome, Depression Disorder, Insomnia, Perceived Stress
- Trial name
- COMET (NCT07707453)
- Where
- 3 sites in Switzerland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Acute Cholecystitis
Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study
The best management of the acute cholecystitis is to do laparoscopic cholecystectomy. The hypothesis is that to do it as an early intervention after patient admission is better than delayed cholecystectomy regarding the hospital…
- Trial name
- NCT02130245
- Testing
- Early cholecystectomy, Delayed cholecystectomy
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Cognitive Impairment, Cognitive Decline
A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults
The potential impact of various dietary ingredients to improve cognitive function, mood, well-being, and overall levels of affects are largely undetermined.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders in Old Age, Well-Being, Psychological
- Trial name
- COG (NCT05994391)
- Testing
- LasoperinTM, Placeo
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Bloating
Diaphragmatic Breathing for the Treatment of Bloating and Distension
The purpose of this study is to evaluate the efficacy of diaphragmatic breathing using the validated Mayo Bloating Questionnaire.
- Trial name
- NCT06596759
- Testing
- Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Aorta Disease, Aorta Aneurysm
Assess Abdominal Aortic Diameter in Females
Female subjects aged 50 years or older will be enrolled. Biometric data (measurements) of the aorta and iliac vessels, demographic data, pathophysiological history, and data relating to menarche, pregnancy/infertility, and…
- Trial name
- AFRODITE (NCT07487961)
- Where
- Italy
- Volunteers
- 652 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Personal Protective Equipment, Airway Management
Evaluation of The Effects of Personal Protective Equipment During Airway Management
Covid-19 disease has caused a worldwide pandemic. However, it was necessary to reduce the transmission of the disease as much as possible. The highest risk of transmission is airway management.
- Trial name
- NCT04866446
- Testing
- endotracheal intubation and laringeal mask airway insertion
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Kezban Aydan Okuyucu
Burden of Surgical Disease in Western Kenya
The Burden of Pediatric Surgical Conditions in Rural Kenya
PURPOSE OF THE STUDY The main purpose of this study is to find out what is the true burden of surgical conditions in pediatric population in a well defined geographical rural area in western Kenya.
- Trial name
- NCT02564783
- Testing
- No intervention
- Where
- Kenya
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Vaccine Response Impaired
Vaccine Hyporesponse in Healthy Elderly Participants (MK-0000-131 AM2)
This study evaluated whether it is possible in healthy elderly participants to generate baseline biomarker-based prediction rules (PdR) for vaccine response (post baseline absolute serum antibody titer) using each of the protocol…
- Trial name
- NCT01119703
- Testing
- Tetanus & Diphtheria booster vaccine (Td), TwinrixTM [Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine], Dukoral® Traveler's Diarrhea Vaccine (WC/rBS)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Celiac Disease
Study for Identifying Optimal Simvastatin Formulation for Uniform Time to Maximum Plasma Concentration
The inter- and intra-variability in the pharmacokinetic parameters of different formulations and doses of simvastatin in healthy subjects and in subjects with celiac disease in remission will be evaluated.
- Trial name
- NCT01642862
- Testing
- Simvastatin
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neonatal Hyperbilirubinemia
Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study)
Background: Neonatal hyperbilirubinemia is the most common reason for admission in the neonatal period (first month of life) worldwide and at SMRU.
- Trial name
- NCT02361788
- Where
- Thailand
- Volunteers
- 1,710 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Participants of the Be-MaGIC-Study 2009
Prospective Follow-up, Marathon, Long Term, Inflammation and Cardiovascular System
Pro-MagIC is a prospective observational study and includes participants of the Be-MaGIC-Study 2009 (n=277/NCT00933218). We aim to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by…
- Trial name
- Pro-MagIC (NCT04166903)
- Where
- Germany
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Gastro-Intestinal Disorder, Crohn Disease
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
The goal of this observational study is to learn about the comparisons of inflammatory markers between IBD and non-IBD (control) participants.
- Conditions
- Gastro-Intestinal Disorder, Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NAZA (NCT06956703)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Tetraplegia, Respiratory Failure
Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome.
To estimate, in a longitudinal and not invasive way, in patients with SGB at respiratory risk, the function of respiratory muscles and that of the upper airways muscles by investigating the force of the tongue, the gulp, and the…
- Trial name
- DGVSB (NCT01024088)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ABO Blood Type, RhD Blood Type
Performance Study of the INSTI® and TruPlex Rapid Blood Typing Platforms
CLS-019A is a prospective, multi-site, parallel clinical performance study. Each enrolled subject is tested on both investigational devices in parallel within a single study visit, yielding paired INSTI® and TruPlex results from…
- Trial name
- NCT07770360
- Testing
- INSTI® Rapid Blood Type Test, TruPlex Rapid Blood Type Test
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
Chronic Kidney Disease
Evaluation of Kidney Fibrosis Via FAPI PET/CT
Interstitial fibrosis is a hallmark of progression in chronic kidney disease (CKD), yet it can presently be assessed only by kidney biopsy, which is invasive and prone to sampling error.
- Trial name
- NCT07712679
- Testing
- PET/CT scan
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pruritus
Naloxone for the Treatment of Opioid-Induced Pruritus
The purpose of this study is to improve how we treat itching, a common side effect associated with the use of morphine pain medication.
- Trial name
- NCT01071057
- Testing
- Naloxone, Saline/Morphine
- Where
- Canada
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Oral Hygiene
Evaluation of the Influence of Radiofrequency-based Toothbrush on the Accumulation of Calculus
to evaluate the influence of radiofrequency based toothbrush (Silk'n toothwave)on the accumulation of the calculus
- Trial name
- NCT04640857
- Testing
- Silk'n Toothwave
- Where
- Israel
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
SARS-CoV-2 Infection, Influenza Viral Infections
Mucosal Immunity: Influence on Infectious Viral Load: a Prospective Observational Study
The goal of this observational study is to learn about the influence of pre-existing mucosal immunity, i.e. antibodies and immune cells that are present at the nasal mucosa before infection, on the infectious viral load after…
- Conditions
- SARS-CoV-2 Infection, Influenza Viral Infections, Virus Shedding, Mucosal Immunity
- Trial name
- MIViral (NCT05794412)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diseases or Conditions
Clinical Profile and Outcome of Perforated PUD
Perforated peptic ulcer disease (PPUD) is series illness that need emergency intervention. Its overall clinical profile and treatment outcome was also not well studied in developing countries.
- Trial name
- PUD (NCT06421064)
- Testing
- Perforation repair
- Where
- Ethiopia
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Badhaasaa
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