Clinical trials: Prostate Cancer Detection
Prostate Carcinoma
Transperineal Micro-ultrasound for the Detection of Prostate Cancer During Biopsy
This clinical trial studies whether transperineal micro-ultrasound can be used to detect prostate cancer during biopsy. Transrectal ultrasound is often used during prostate biopsy.
- Trial name
- NCT07075705
- Testing
- Biopsy of Prostate, Magnetic Resonance Imaging, Micro-ultrasound Imaging
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Prostate Cancer
Head-to-head Comparison of 68Ga-PSMA-11 and 18F-PSMA-1007
The aim of this study is to provide robust data on the head-to-head comparison of the two ligands of the prostate specific membrane antigen (PSMA) available in Switzerland for positron emission tomography (PET)-imaging, i.e.
- Trial name
- NCT05079828
- Testing
- 18F-PSMA-1007, 68Ga-PSMA-11
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prostate Cancer
MRI Before Biopsy in Diagnosing Patients With Prostate Cancer
This pilot clinical trial studies how well magnetic resonance imaging (MRI) before biopsy works in diagnosing patients with prostate cancer.
- Trial name
- NCT02131207
- Testing
- magnetic resonance imaging, prostate biopsy
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Comparative Analysis of Transperineal Versus Transrectal Approaches for MRI-Targeted Biopsy of the Prostate for the Detection and Characterization of Prostate Cancer
The purpose of this study is to investigate a transperineal biopsy approach (outside of the rectum) using MRI targeting to facilitate better access to the whole prostate gland and provide limited risk of infectious complications…
- Trial name
- NCT03366792
- Testing
- Artemis™ software system
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Prostatic Carcinoma
Imaging of High Grade Prostate Cancer
Management of prostatic carcinoma varies according to stage of disease. Trans-rectal ultrasound guided biopsy is known to underestimate the degree of tumor due to undersampling and random non-targeted technique.
- Trial name
- NCT02177526
- Testing
- Imaging
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Prostate Cancer
Comparing PSMA PET/CT and MRI-RSI for Finding and Outlining Tumors Inside the Prostate in Men With Newly Diagnosed Prostate Cancer
The detection and delineation of the intraprostatic tumor burden plays a crucial role in the personalized treatment of primary prostate cancer.
- Trial name
- PRIDE2-PC (NCT07568613)
- Testing
- MRI, 18F-PSMA1007 PET-CT, MR-guided TRUS Prostate biopsy
- Where
- Cyprus
- Volunteers
- 50 people
- Sponsor
- German Oncology Center, Cyprus
Prostate Carcinoma
Micro-Ultrasound for the Detection and Localization of Prostate Cancer Tumors in Patients Undergoing Radical Prostatectomy
This trial studies the ability of micro-ultrasound to detect and characterize prostate cancer tumors in patients undergoing radical prostatectomy (removal of the entire prostate and some of the tissue around it).
- Trial name
- NCT04299620
- Testing
- Digital Image Analysis, Radical Prostatectomy, Transrectal Ultrasound
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Advanced Prostate Cancer, Metastatic Prostate Cancer
Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT
This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of advanced prostate cancer that either has low…
- Conditions
- Advanced Prostate Cancer, Metastatic Prostate Cancer, Metastatic Prostate Neuroendocrine Carcinoma
- Trial name
- NCT06062745
- Testing
- 18F-fluciclovine, PET/CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Stage II Prostate Adenocarcinoma, Stage III Prostate Adenocarcinoma
68Ga-PSMA-11 PET/MRI in Finding Tumors in Patients With Intermediate or High-Risk Prostate Cancer Undergoing Surgery
This phase 2-3 trial studies the utility of 68-gallium (68Ga)-prostate-specific membrane antigen 11 (PSMA-11) positron emission tomography/magnetic resonance imaging (PET/MRI) to find tumors in patients with prostate cancer who…
- Trial name
- NCT02678351
- Testing
- 68Ga-PSMA-11, Magnetic resonance imaging (MRI), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Andrei Iagaru
Prostate Cancer
Comparing MRI-Ultrasound Fusion and Cognitive-guided Biopsy for the Detection of csPCa: the PROFUSION Trial
This study is an international multicentre RCT to compare the linically significant prostate cancer (csPCa) detection of cognitive-guided and MRI-USG guided biopsies in men with suspicious MRI lesion.
- Trial name
- NCT06303622
- Testing
- MRI-USG fusion approach, Cognitive-guided approach
- Where
- Hong Kong
- Volunteers
- 1,620 people
- Sponsor
- Chinese University of Hong Kong
Prostate Adenocarcinoma, Recurrent Prostate Carcinoma
Gallium Ga 68-labeled PSMA-11 PET/CT in Detecting Recurrent Prostate Cancer in Patients After Initial Therapy
This clinical trial studies how well gallium Ga 68-labeled prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) works in detecting prostate cancer that has come back (recurrent)…
- Trial name
- NCT02940262
- Testing
- Gallium Ga 68 Gozetotide, Laboratory Biomarker Analysis, Positron Emission Tomography
- Where
- United States
- Volunteers
- 1,138 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer Metastatic to Bone
Diagnostic Imaging of Bone Metastases in Prostate Cancer Patients
An improved diagnosis of bone metastases in prostate cancer patients can have a significant impact on treatment strategy and probably survival as well.
- Trial name
- DIMAB (NCT03134261)
- Testing
- WB-MRI, SPECT-CT, Cholin-PET-CT
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Herlev Hospital
Advanced Prostate Carcinoma, Cancer of Prostate
Darolutamide + Consolidation Radiotherapy in Advanced Prostate Cancer Detected by PSMA
Darolutamide is a drug that has a proven survival benefit in non-metastatic (M0) castrate resistant prostate cancer when using conventional imaging.
- Conditions
- Advanced Prostate Carcinoma, Cancer of Prostate, PSA, Castrate Resistant Prostate Cancer
- Trial name
- DECREASE (NCT04319783)
- Testing
- Darolutamide, Radiotherapy
- Where
- 16 sites in Australia, Singapore
- Volunteers
- 65 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Benign Prostatic Hyperplasia, Prostatitis
2013 Annual National Digital Rectal Exam (DRE) Day Study
We aim to determine the effectiveness of 2013 "Mag paDRE ka" programme in increasing general public awareness on prostate health and promoting prostate health assessment among Filipino males aged 40 or older.
- Conditions
- Benign Prostatic Hyperplasia, Prostatitis, Prostate Cancer
- Trial name
- NCT01886547
- Testing
- Prostate health screening
- Where
- Philippines
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- St. Luke's Medical Center, Philippines
Prostate Cancer
Detection of Viable CTCs Using the EPIDROP Technology in Metastatic Prostate Cancer (EPIDROP)
The use of liquid biopsy could be the key for precision medicine. Circulating tumor cells (CTCs) are the most studied circulating biomarkers used to assess the metastatic process and they have shown their clinical validity and…
- Trial name
- EPIDROP (NCT04581109)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Prostate Cancer, Prostate Adenocarcinoma
Detection of Prostate Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC
Prostate cancer is a leading cause of mortality and morbidity. The purpose of this study is to develop and test non-invasive biomarkers based on methylation changes in PBMC, T-cells and circulated tumor DNA in prostate cancer…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic
- Trial name
- NCT03494803
- Where
- Kazakhstan
- Sponsor
- HKGepitherapeutics
Prostate Cancer, Prostate Neoplasm
Early and Accurate Detection of Prostate Cancer in General Practice
Prostate cancer (PC) is the most common malignancy (4500 new cases/year) and the second leading cause of cancer-associated mortality (1200 deaths/year) among men in Denmark.
- Conditions
- Prostate Cancer, Prostate Neoplasm, Prostate Adenocarcinoma
- Trial name
- NCT03431753
- Testing
- PSA, STHLM3 and mpMRI for PC detection
- Where
- Denmark
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Prostate Cancer
Randomized Prospective Multi Center Cohort Study for Primary Diagnosis of Clinically Significant Prostate Cancer With Combination of PSA/DRE and Multi Parametric Magnetic Resonance Imaging
This randomized prospective multi center study is designed to confirm a new diagnostic pathway in primary diagnosis of clinically significant prostate cancer by combination of serum levels of prostate specific antigen (PSA)…
- Trial name
- PRIMA (NCT04993508)
- Testing
- PSA test, multiparametric prostate Magnetic Resonance Imaging (mpMRI), targeted MRI/US fusion-guided biopsy
- Volunteers
- 1,908 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Brain Cancer, Prostate Cancer
Feasibility Study of Tumor Blood Flow Measurement by Detection of Positron Activation Post Proton Therapy (DS01)
The purpose of this study is the development of noninvasive (having no direct contact) detector and electronic system that will directly measure tumor blood flow rate.
- Conditions
- Brain Cancer, Prostate Cancer, Lung Cancer
- Trial name
- NCT01987193
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Prostate Cancer
AI Algorithm-Informed Biopsy for Prostate Cancer Detection With Indeterminate and Low-Risk Prostate MRI Lesions
Use of AI algorithm for PCa detection is feasible, and AI-informed biopsies (AI-targeted and perilesional biopsy) improves csPCa detection in patients with indeterminate MRI lesions and in patients with low-risk MRI lesions and…
- Trial name
- NCT07231627
- Testing
- Bi-parametric MRI-based cascaded deep-learning AI algorithm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arkansas