Clinical trials: Provoked Vestibulodynia
Vulvodynia
A Phase 2 Study to Evaluate the Efficacy and Safety of Pudafensine in Vulvodynia (Provoked Vestibulodynia)
The study (IP2015CS05) is a randomised, double-blind, placebo-controlled, 4-way cross-over trial studying the efficacy and safety of single dose administration of pudafensine in vulvodynia (provoked vestibulodynia) patients.
- Trial name
- NCT07391241
- Testing
- Pudafensine
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Initiator Pharma
Provoked Vestibulodynia
Dry Needling for Provoked Vestibulodynia
This is a randomized and controlled study investigating the feasibility and acceptability of a dry needling treatment for women suffering from provoked vestibulodynia.
- Trial name
- NCT05797480
- Testing
- Real Dry needling, Non penetrating dry needling
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Université de Sherbrooke
Dyspareunia (Female)
Rigid Hymenal Ring as a Cause for Insertional Dyspareunia
Given the frequently observed rigid hymenal ring as a cause of insertional dyspareunia as well as the resolution of pain (including posterior vestibulodynia) following its targeted therapy, the study aims to describe its…
- Trial name
- NCT07913386
- Testing
- Hymenectomy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Provoked Localized Vulvodynia
Subtypes of Provoked Vestibulodynia
The proposed study will evaluate a clinical algorithm for the diagnosis and treatment of provoked vestibulodynia (PVD). The algorithm, distinguishes between four subtypes of PVD: hormonally mediated PVD, hypertonic pelvic floor…
- Trial name
- NCT02712814
- Testing
- Topical hormonal cream (estrogen), Pelvic floor physical therapy, Low Level Laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Provoked Vestibulodynia
Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial
Provoked vestibulodynia (PVD) is the most common form of vulvodynia and despite its high prevalence and important sexual, conjugal and psychological deleterious repercussions, effective evidence-based interventions remain…
- Trial name
- PVD/tDCS (NCT02543593)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Vulvodynia
High-level Laser for Provoked Vestibulodynia
This is a randomized feasibility and acceptability study investigating the effects of laser treatment in women suffering from provoked vestibulodynia compared to a sham-laser treatment.
- Trial name
- NCT04502810
- Testing
- High-level laser therapy
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Université de Sherbrooke
Vulvodynia, Provoked Vestibulodynia
Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health
This trial will provide evidence for the effective management of pain and pain-related domains among those who experience provoked vestibulodynia (PVD) using photobiomodulation (PBM) and multimodal physiotherapy (mPT) in a…
- Conditions
- Vulvodynia, Provoked Vestibulodynia, Dyspareunia
- Trial name
- BRIGHT (NCT06660212)
- Testing
- Photobiomodulation, Multimodal physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
Localized Provoked Vulvodynia
The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia
The proposed study will evaluate how personality characteristics, cognitive factors and the emotional and behavioral responses of patients with provoked vestibulodynia (localized provoked vulvodynia) influence the natural history…
- Trial name
- NCT02892214
- Testing
- Pelvic floor physical therapy, estriol cream (ovestin), Low-level-laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Lichen Sclerosus, Lichen Planus
Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis
The objective of the study was to determine sensitivity, specificity and diagnostic accuracy of "Three Rings Vulvoscopy" for detection of vulvar dermatosis using histopathology as the reference standard.
- Conditions
- Lichen Sclerosus, Lichen Planus, Lichen Simplex Chronicus, Vulvodynia
- Trial name
- DATRIV (NCT02732145)
- Testing
- "Three Rings Vulvoscopy" (TRIV), Histopathology
- Where
- Croatia
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Ginekološka Poliklinika Dr. Vesna Harni
Vestibulodynia
A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia
This study aims to assess the pain on contact in provoked vestibulodynia, measured with Visual Analogic Scale at week 0/week 2/week 6/week 12 after applying a patch of capsaicin.
- Trial name
- CAPSIVU (NCT02854670)
- Testing
- Capsaicin patch
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Provoked Vestibulodynia
Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia
Provoked vestibulodynia, previously called vulvar vestibulitis syndrome, is clinically defined as chronic, unexplained, vulvar pain or discomfort confined to the vulvar vestibule in response to contact or pressure.
- Trial name
- LLLT (NCT01149031)
- Testing
- LOW LEVEL LASER SYSTEM
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Provoked Vestibulodynia
Integrated Mindfulness for Provoked Vestibulodynia
This study aims to test the efficacy of a 4-session intervention (Group psychoeducational treatment) using a randomized study design. Participants will be randomized in to 'immediate treatment' or 'waitlist control'.
- Trial name
- IMPROVED (NCT01704443)
- Testing
- Group Psychoeducational Treatment, Waitlist control
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- University of British Columbia
Vestibulodynia
Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia
There have been reports in the medical literature demonstrating a link between the development of provoked vestibulodynia (PVD), a sexual pain disorder, and hormonal contraceptive (HC) use.
- Trial name
- NCT01741948
- Testing
- Hormonal contraceptive
- Where
- 2 sites in Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- ahinoam lev sagie
Vestibulodynia
Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia
Chronic gynaecological pain is a major medical problem that affects 20-30% of women at different moments of their life. This largely neglected issue has a significant impact on the sexual and conjugal life of women suffering from…
- Trial name
- NCT01455350
- Testing
- Multimodal physiotherapy, lidocaine
- Where
- 2 sites in Canada
- Volunteers
- 212 people
- Sponsor
- Université de Sherbrooke
Vulvar Vestibulitis
Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia
The purpose of the study was to compare the effectiveness of cognitive behavioural therapy (CBT) and physical therapy (PT) on pain and psychosexual outcomes in women with provoked vestibulodynia (PVD).
- Trial name
- NCT02494934
- Testing
- cognitive-behavioural therapy, physical therapy
- Volunteers
- 20 people
- Sponsor
- Queen's University
Provoked, Localized Vulvodynia, Provoked Vestibulodynia
Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study
The investigators research project is a randomized, controlled, single-blinded, feasibility pilot study. The investigators will study the feasibility of a novel treatment for women with Provoked Localized Vulvodynia (PLV) with…
- Conditions
- Provoked, Localized Vulvodynia, Provoked Vestibulodynia, Vulvar Vestibulitis, Vulvodynia
- Trial name
- NCT01996384
- Testing
- Classical Acupuncture, Non-classical acupuncture, Lidocaine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Oregon College of Oriental Medicine
Vestibulodynia
A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia
The main objective of this study is to compare the efficacy of botulinum toxin injections on vestibulodynia pain compared to a group treated with a placebo.
- Trial name
- VESTIBULE (NCT02858219)
- Testing
- Botulinum Toxin Type A, Saline solution, Indexes
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Vestibulodynia
Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia
Vulvodynia is a debilitating chronic vulvar pain lasting at least 3 months without a clear identifiable cause that is challenging to treat effectively.
- Trial name
- NCT03390049
- Testing
- Fractional CO2 Laser Treatment
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Vestibulodynia
Feasibility Study for Provoked Vestibulodynia
The feasibility and acceptability of a somatosensory rehabilitation program and an educational pain management program will be investigated in women with provoked vestibulodynia.
- Trial name
- NCT05342402
- Testing
- Somatosensory Rehabilitation Program, Educational Pain Management Program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Provoked Vestibulodynia
Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
This randomized trial, nicknamed the COMFORT (Cognitive therapy or Mindfulness FOR Treatment of pvd) study, will compare the effects of an 8-session group Mindfulness-based Cognitive Therapy (MBCT) to an 8-session group Cognitive…
- Trial name
- COMFORT (NCT01704456)
- Testing
- Mindfulness-based Cognitive Therapy, Cognitive Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- University of British Columbia