Clinical trials: Pseudomelia
Phantom Limb Pain
Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
When a limb is traumatically severed, pain perceived in the part of the body that no longer exists often develops. This is called "phantom limb" pain, and is different from "stump" pain, which is pain within the part of the limb…
- Trial name
- DoD-PLP-Tx (NCT01824082)
- Testing
- Perineural infusion [continuous peripheral nerve block(s)]
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Diego
Amputation
AMI Construction in Lower Extremity Residual Limbs
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
- Trial name
- NCT04063592
- Testing
- Residual limb revision
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lower Limb Amputation Below Knee (Injury)
Descriptive Study of Receptive Fields in Lower Limb Amputees
It has been observed that patients subjected to amputations develop so called receptive fields, which time of occurrence and localization over time are yet not examined systematically.
- Trial name
- NCT03348605
- Testing
- Phantom Stimulator, Cort X Sensorics, Spaichingen, Germany
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- Rehaklinik Bellikon
Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Virtual Reality Treatment for Phantom Limb Pain
Patients with limb amputations experience the sensation of the missing extremity, which is sometimes coupled with a persistent and debilitating pain in the missing limb, a condition known as phantom limb pain (PLP).
- Conditions
- Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Phantom Limb Pain
- Trial name
- NCT03338842
- Testing
- Distractor and Lower limb VR
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Amputation, Phantom Limb
A Study to Test the Effectiveness of Mirror-Box and Mental Visualization Treatments on Phantom Limb Pain
The researchers propose to conduct a pilot study on the efficacy of mirror-box and mental visualization treatments on phantom limb pain.
- Conditions
- Amputation, Phantom Limb, Pain
- Trial name
- NCT00301444
- Testing
- mirror-box treatment, Mental visualization
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Amputation, Sensation, Phantom
Sensory Responses to Dorsal Root Stimulation
The goal of this project is to characterize the types of sensations that can be evoked via electrical stimulation of the spinal cord and spinal nerves.
- Trial name
- NCT04725006
- Testing
- Spinal cord stimulation system
- Where
- United States
- Sponsor
- Lee Fisher, PhD
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Phantom Limb Pain
Predicting Pain Response to Transcranial Direct Current Stimulation for Phantom Limb Pain in Limb Amputees
This study explores the effects transcranial Direct Current Stimulation (tDCS, Soterix ©) on Phantom Limb Pain for patients experiencing chronic phantom limb pain in open-label study design.
- Trial name
- NCT02627495
- Testing
- transcranial Direct Current Stimulation (tDCS): (Soterix ©)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Spaulding Rehabilitation Hospital
Ischemia, Phantom Limb Pain
Sciatic Perineural Versus Stump Catheter for Below Knee Amputation
The goal of this study is to determine if pre-operative placement of the continuous peripheral nerve block by an anesthesiologist using ultrasound technology is more effective than a continuous peripheral nerve block placed…
- Conditions
- Ischemia, Phantom Limb Pain, Vascular Disease, Chronic Pain
- Trial name
- NCT01608035
- Testing
- Sciatic catheter, Stump catheter
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University of British Columbia
Amputation, Neuroma Amputation
Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain
The purpose of this study is to analyze the efficacy of novel interventions in post-amputation surgical care (specifically Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface) on post-amputation pain and…
- Conditions
- Amputation, Neuroma Amputation, Phantom Limb Pain, Residual Limbs
- Trial name
- NCT05344261
- Testing
- Targeted Muscle Re-innervation, Regenerative Peripheral Nerve Interface, Standard Post-Amputation Surgical Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Phantom Limb Pain, Neuropathic Pain
Nabilone for the Treatment of Phantom Limb Pain
The purpose of this proposed study is to conduct a randomized double-blind placebo controlled trial assessing the benefit of nabilone in pain management and improvement of quality of life in patients with phantom limb pain.
- Trial name
- NCT00699634
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Phantom Limb Pain
Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Phantom Limb Pain in Landmine Victims: ANTARES
Phantom Limb Pain (PLP) is a neuropathic chronic syndrome, characterized by a painful sensation in a body part that has been amputated.
- Trial name
- ANTARES (NCT01872481)
- Testing
- rTMS
- Where
- Colombia
- Volunteers
- 54 people
- Sponsor
- Fundación Cardiovascular de Colombia
Targeted Sensory Reinervation, Amputation
Targeted Sensory Reinnervation (TSR) in Hand Amputation
If a person has to have a part of their body amputated, in this case their hand, the patient then lacks information about the missing limb, which in many cases leads to pain that severely restricts their quality of life and…
- Conditions
- Targeted Sensory Reinervation, Amputation, Phantom Pain
- Trial name
- NCT06249594
- Testing
- targeted sensory reinervation
- Where
- 2 sites in Austria, Italy
- Volunteers
- 3 people
- Sponsor
- Brixsana Private Clinic - Centro di Chirurgia Plastica, Estetica ed Ricostruttiva con Chirurgia dell
Phantom Limb Pain
Examining Brain Changes Using Functional Magnetic Resonance Imaging (fMRI) in Amputees With Phantom Limb Pain Following Mirror Therapy
Almost everyone who has a traumatic limb amputated will experience a phantom limb - the vivid impression that the limb not only still is present, but also in many cases, painful.
- Trial name
- NCT00662415
- Testing
- mirror-box treatment, observation
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Phantom Limb Pain
Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation
The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using…
- Trial name
- NCT06813937
- Testing
- Procedure: Peripheral Magnetic Stimulation (PMS), Electroencephalography (EEG)
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Phantom Limb Pain
Mixed Reality Based System to Manage Phantom Pain Phantom Pain for Patients With Lower Limb Amputation
The primary goals of this pilot research project are a) to design and develop the a mixed reality based system for managing phantom pain and b) to evaluate the feasibility and preliminary functional outcomes of this system in a…
- Trial name
- MrMAPP (NCT04529083)
- Testing
- Mr. MAPP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Dallas VA Medical Center
Amputation, Surgical, Phantom Limb Pain
Prevention of PostAmputation Pain With Targeted Muscle Reinnervation
The goal of this study is to compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients who received a lower extremity amputation (LEA) with standard nerve handling (neurectomy)…
- Conditions
- Amputation, Surgical, Phantom Limb Pain, Neuroma Amputation, Surgery
- Trial name
- PreventPAP (NCT06719245)
- Testing
- Targeted Muscle Reinnervation (TMR), Standard neurectomy
- Where
- 7 sites in Netherlands
- Volunteers
- 203 people
- Sponsor
- Leiden University Medical Center
Phantom Limb Pain
Home-based Self-delivered Mirror Therapy for Phantom Limb Pain
The goals of the study are to determine whether self-delivered, home-based mirror therapy decreases the frequency and intensity of phantom limb pain and improves mood and physical function in persons with phantom limb pain.
- Trial name
- NCT00827294
- Testing
- Mirror Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Phantom Limb Pain
Use of Hand Prosthesis With Surface Electrical Stimulation for Treatment of Phantom Limb Pain
Phantom limb pain (PLP) is a frequent consequence of amputation, and it is notoriously difficult to treat. Amputation usually follows traumatic injuries or surgery following vascular diseases, diabetes, osteomyelitis or tumours…
- Trial name
- EPIONE (NCT02569918)
- Testing
- Surface electrical stimulation
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof. Wassim Raffoul