Clinical trials: Pseudomyxoma Peritonei
Mesothelioma; Peritoneum, Pseudomyxoma Peritonei
Thrombin Generation and Platelet Activation in CRS/HIPEC
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal peroperative chemotherapy (HIPEC), indicated for patients with peritoneal metastases from digestive or gynecological malignancies alike, demonstrates a considerable…
- Conditions
- Mesothelioma; Peritoneum, Pseudomyxoma Peritonei, Peritoneal Carcinomatosis
- Trial name
- NCT03034850
- Testing
- CRS/HIPEC
- Volunteers
- 27 people
- Sponsor
- Ziekenhuis Oost-Limburg
Colorectal Cancer Metastatic
Quality of Life After Cytoreductive Surgery and Intraperitoneal Chemotherapy
Cytoreductive surgery with intraperitoneal chemotherapy is one of the most important treatments for patients with colorectal cancer and peritoneal metastasis.
- Trial name
- NCT03503071
- Testing
- Cytoreductive surgery and intraperitoneal chemotherapy
- Where
- South Korea
- Sponsor
- Kyungpook National University Hospital
Gastrointestinal Neoplasms
Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal Adenocarcinomas With Pseudomyxoma Peritonei
Appendiceal cancer is a rare disease that does not cause many symptoms. As such, doctors are not sure if chemotherapy actually has an effect on the disease.
- Trial name
- NCT01946854
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Peritoneal Carcinomatosis, Pseudomyxoma Peritonei
Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed
The purpose of this study is to register the follow-up data of patients who, because of a peritoneal surface malignancy, will undergo cytoreductive surgery and HIPEC.
- Conditions
- Peritoneal Carcinomatosis, Pseudomyxoma Peritonei, Peritoneal Mesothelioma
- Trial name
- HIPEC (NCT01617382)
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Peritoneal Cancer, Pseudomyxoma Peritonei
Phase I Trial HIPEC With Nal-irinotecan
The purpose of this study is to assess the effectiveness and safety of intraperitoneal administration of heated nanoliposomal Irinotecan in cytoreductive surgery (CRS), which is surgery designed to remove as much of the cancer as…
- Conditions
- Peritoneal Cancer, Pseudomyxoma Peritonei, Mucinous Adenocarcinoma, Mucinous Tumor
- Trial name
- NCT04088786
- Testing
- nanoliposomal irinotecan
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Stony Brook University
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy
Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC
Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes.
- Conditions
- Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Hydration, Diuresis
- Trial name
- NCT05939193
- Testing
- Urine-guided hydration, Routine hydration, Forced administration of furosemide
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Peking University First Hospital
Peritoneal Carcinomatosis
Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC
Peritoneal carcinomatosis from advanced gastro-intestinal malignancy has historically been associated with poor overall survival (≤ 12 months) with few treatment options.
- Trial name
- NCT04779554
- Testing
- Mitomycin C, flat dose 40 mg, Mitomycin C, weight-based dose 12.5 mg/m2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Prakash Pandalai
Peritoneal Neoplasms
A Phase II Study of Surgical Debulking With Peritonectomy and Biweekly Intraperitoneal 5FU With Systemic Oxaliplatin/5FU/Leucovorin in Patients With Pseudomyxoma Peritonei or Peritoneal Carcinomatosis
This study prospectively evaluates a multidisciplinary approach to patients with intraperitoneal carcinomatosis at Washington University.
- Trial name
- NCT00352755
- Testing
- Surgical debulking with peritonectomy, Intraperitoneal 5FU, FOLFOX
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Pseudomyxoma Peritonei, Postoperative Delirium (POD)
Proactive Temperature Management in CRS-HIPEC for Prevention of Delirium
This randomized controlled trial evaluates the efficacy of a proactive Goal-Directed Temperature Management (GDTM) protocol in reducing postoperative delirium among patients undergoing Cytoreductive Surgery (CRS) with…
- Trial name
- NCT07378371
- Testing
- Proactive Goal-Directed Temperature Management, Standard Reactive Temperature Management
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Aerospace Center Hospital
Pseudomyxoma Peritonei, Cytoreductive Surgery
What Are the Experiences of Patients With Pseudomyxoma Peritonei?
Complete cytoreductive surgery (CCRS) is an extensive, and potentially curative, procedure utilised for peritoneal malignancies including Pseudomyxoma peritonei (PMP).
- Conditions
- Pseudomyxoma Peritonei, Cytoreductive Surgery, Recovery
- Trial name
- NCT04125225
- Where
- United Kingdom
- Sponsor
- University of Southampton
Ventral Hernias, Cytoreductive Surgery
Ventral Hernias Following Cytoreductive Surgery : Incidence, Risk Factors and Surgical Management.
Cytoreductive surgery (CRS), with or without hyperthermic intraperitoneal chemotherapy (HIPEC), is currently the standard treatment for advanced peritoneal tumors, including pseudomyxoma peritonei (PMP), colorectal, and ovarian…
- Trial name
- NCT07451483
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jules Bordet Institute
Peritoneal Carcinomatosis, Colorectal Cancer
HIPEC for Peritoneal Carcinomatosis
This is a clinical study investigating the new treatment of surgery combined with intraperitoneal mitomycin-C for patients with gastrointestinal cancer that has spread to the peritoneal (abdominal cavity) surface.
- Conditions
- Peritoneal Carcinomatosis, Colorectal Cancer, Appendiceal Cancer, Peritoneal Mesothelioma
- Trial name
- NCT02040142
- Testing
- HIPEC, Mitomycin C
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Albert Einstein College of Medicine
Pseudomyxoma Peritonei, Appendiceal Neoplasms
Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin
The purpose of this study is to determine the impact of antibiotic therapy on the disease progression and overall survival of patients with Pseudomyxoma Peritonei (PMP).
- Trial name
- NCT02387203
- Testing
- PrevPac (Prevacid, Amoxicillin, Clarithromycin)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mercy Medical Center
Pseudomyxoma Peritonei, Appendiceal Neoplasm
Gastrointestinal Microbiome Study of Appendiceal Cancer
This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
- Conditions
- Pseudomyxoma Peritonei, Appendiceal Neoplasm, Cancer, Appendiceal
- Trial name
- NCT02599116
- Testing
- Bio-specimen collection, Questionnaire
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mercy Medical Center
Peritoneum Cancer, Peritoneum Neoplasm
International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)
Multicentric, international, web-based prospective documentation of the indications and results of Pressurized Aerosol Chemotherapy (so-called PIPAC or PITAC) for treating malignant pleural and peritoneal diseases.
- Conditions
- Peritoneum Cancer, Peritoneum Neoplasm, Pleural Cancer, Pleural Effusion
- Trial name
- PIPACRegis (NCT03210298)
- Testing
- PIPAC
- Where
- 16 sites in Argentina, Australia and 11 more
- Volunteers
- 1,000 people
- Sponsor
- Sabine Rhode
Carcinoma of the Appendix, Colorectal Cancer
Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer
RATIONALE: Thalidomide may stop the growth of tumor cells by blocking blood flow to the tumor. Giving thalidomide after surgery and chemotherapy may kill any remaining tumor cells.
- Trial name
- NCT00310076
- Testing
- thalidomide, surgery
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Acquired Fibrinogen Deficiency
Phase 3 Study of Fibrinogen Concentrate (CSL511) in Subjects With Pseudomyxoma Peritonei Undergoing Cytoreductive Surgery
This study is a phase 3, prospective, single center, randomized, open label, controlled, parallel arm, interventional study to investigate the efficacy and safety of CSL511, in participants undergoing cytoreductive surgery (CRS)…
- Trial name
- NCT06617897
- Testing
- CSL511 Fibrinogen concentrate (human), Cryoprecipitate
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- CSL Behring
Anxiety Disorder, Depression
Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer
This pilot clinical trial studies stress reduction in improving quality of life in patients with recurrent gynecologic or breast cancer.
- Conditions
- Anxiety Disorder, Depression, Fatigue, Leydig Cell Tumor
- Trial name
- NCT01764789
- Testing
- questionnaire administration, quality-of-life assessment, psychosocial assessment and care
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Appendiceal Mucinous Neoplasm, Pseudomyxoma Peritonei
Metformin in Pseudomyxoma Peritonei Secondary to Appendiceal Mucinous Neoplasms
This is a pilot, open-label clinical trial determining the feasibility of metformin therapy in subjects with pseudomyxoma peritonei (PMP) secondary to appendiceal mucinous neoplasms (AMNs).
- Trial name
- NCT07693452
- Testing
- Metformin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Irvine
Cancer
Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005860
- Testing
- floxuridine, leucovorin calcium, oxaliplatin
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center