Clinical trials: Psychiatric Disorders
Schizophrenia, Schizoaffective Disorder
Anticholinergic Deprescription in Schizophrenia
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with…
- Trial name
- NCT06562608
- Testing
- Anticholinergic Deprescription, No Anticholinergic Deprescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Deepak K. Sarpal, M.D.
Bipolar Disorder, Depression
A Study Of Kappa Opioid Receptor Occupancy Of PF-04455242, Using PET (Positron Emission Tomography)
This is a subject blind, investigator and sponsor open, randomized study consisting of 2 parts. Up to 15 healthy subjects will be included in the study.
- Trial name
- NCT00939887
- Testing
- PF-04455242
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Opioid Use Disorder
Investigation of the Pharmacokinetic Profile of CBD
The goal of the current study is to evaluate the bioavailability of CBD in normal healthy Individuals. This is an open cross-overdesign study in healthy individuals to assess the safety and pharmacokinetic (PK) effects of…
- Trial name
- NCT05269706
- Testing
- Cannabidiol 200mg, Epidiolex, Cannabidiol 400mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yasmin Hurd
Primary Insomnia
The Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia
This study examines how treatment with the drug modafinil, by itself or in combination with cognitive behavioral treatment for insomnia (CBT-I), may improve daytime functioning and/or diminish the severity of insomnia.
- Trial name
- NCT00124384
- Testing
- CBT-I, modafinil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Internalizing Psychopathologies (IPs) Depression and Anxiety
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
Internalizing psychopathologies (IPs) involving depression and anxiety are among the most prevalent, costly and disabling illnesses.
- Trial name
- NCT01903447
- Testing
- SSRI, CBT
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Nursing Students
The Effect of Exergames on Sleep Quality
University students are at risk of developing insufficient sleep and poor lifestyle behaviors. Sleep-related problems are frequently seen in nursing students. Regular exercise has a positive effect on sleep quality.
- Trial name
- EXSLEEPQUALITY (NCT06948643)
- Testing
- Play the Oculus Quest 2
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity
Sleep Disorder, Parkinson Disease
Sleep Disorder in Parkinson Disease and rTMS
The crude prevalence rate of Parkinson's disease in Upper Egypt governorates ranging from 557-436/100,000 (Assiut and Qena governorates respectively) which was one of the highest prevalence of PD around the world .Parkinson's…
- Trial name
- NCT05599035
- Testing
- repititive transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assiut University
Substance Use Disorders, Insomnia
Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
The goal of this clinical study is to learn whether treating sleep problems is helpful in people with substance abuse problems who are living in a residential treatment program.
- Trial name
- BBTI_SUDs (NCT05935735)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Quality, Anxiety Level
Hand Massage Applied To Elderly Stayıng In Nursing Homes
Hand massage; behavioral and reduce psychological symptoms, enable individuals to calm down and relax, and provide individual and care It is applied to contribute to communication between donors, to ensure reliability and ease of…
- Trial name
- NCT06872008
- Testing
- Hand Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Amasya University
Attention-deficit/Hyperactivity Disorder
The Metabolome Profiling and Pathway Analysis of ADHD
The purpose of this study is to understand the pathophysiological mechanisms of ADHD, especially the metabolomic pathway related to the behavioral/neuropsychological deficits of ADHD.
- Trial name
- NCT02942225
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Generalized Anxiety Disorder
6-Session Treatment for Generalized Anxiety Disorder
Generalized Anxiety Disorder (GAD) is a chronic condition that is characterized by excessive and uncontrollable worry and anxiety. In Canada, 3 to 4% of the population suffer from GAD at any point in time.
- Trial name
- NCT03433625
- Testing
- Behavioural experiments for intolerance of uncertainty (BE-IU)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Restless Legs Syndrome
Gut Microbiota and Bacterial Translocation in Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a common neurological sensorimotor disorder defined by an urge to move the legs when at rest that increase in the evening and at night.
- Trial name
- RLS-BIOT (NCT05985421)
- Testing
- Fecal collection, Blood sampling, Polysomnography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Dementia
Pilot of a New Cognitive Assessment Tool for Detecting Dementia in the Migrant Somali Population
Aims The investigators want to find out if the tool that they have made to assess memory and thinking in Somali elders ( the 'MSCAT') is acceptable to that community and practical to administer and score.
- Trial name
- NCT05163821
- Testing
- Manchester Somali Cognitive Assessment Tool, ACE-III Somali Translation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Greater Manchester Mental Health NHS Foundation Trust
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy, Involutional Depression
Dynamics of Leptin and Endocrine Function
This is a study investigating the hormones and substances important to the stress response. The hormone that is most directly responsible for stress response is called corticotropin-releasing hormone (CRH).
- Trial name
- NCT00001543
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bulimia Nervosa, Eating Disorders
Cholecystokinin for Reducing Binge Eating in People With Bulimia Nervosa
This study will determine the effectiveness of administrating a dose of cholecystokinin during a binge eating episode in reducing this eating behavior in people with bulimia nervosa.
- Trial name
- NCT00308776
- Testing
- Cholecystokinin (CCK) infusion, Saline infusion
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Interpersonal Relations, Schizophrenia
Exploration of Neural Bases in Social Cognition
An impairment in social cognition in schizophrenia could account for the severe professional and social difficulties among patients. Social cognition is the way the social world is understood, perceived and interpreted.
- Conditions
- Interpersonal Relations, Schizophrenia, Magnetic Resonance Imaging, Functional
- Trial name
- IRM-COG (NCT02110017)
- Testing
- fMRI social cognition task
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Burn (Disorder), Patient
Effect of Progressive Relaxation Exercises on Sleep, Anxiety, and Body Image in Burn Patients
The Importance of Sleep Quality, Anxiety Levels, and Body Image in Burn Patients Sleep quality, anxiety levels, and body image play a significant role in the recovery process and overall quality of life for burn patients.
- Trial name
- Burn Patients (NCT07531004)
- Testing
- Experimental Group, Progrressive relaxation egsercise
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity
Child Developmental Delay, Child Malnutrition
Maternal B12 Supplementation to Improve Infant B12 Deficiency and Neurodevelopment
Vitamin B12 plays a key role in the development and normal functioning of the brain and nervous system. Unborn and new-born infants derive their vitamin B12 stores almost entirely from maternal B12 stores.
- Conditions
- Child Developmental Delay, Child Malnutrition, Maternal Exposure, Vitamin B 12 Deficiency
- Trial name
- MATCOBIND (NCT03783104)
- Testing
- B12 Supplement
- Where
- 2 sites in India, Nepal
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University College, London
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