Clinical trials: Psychogenic Non-Epileptic Seizure
Epilepsy, Psychogenic Non-epileptic Seizures
Study on the Rapid Diagnostic Value of Sudden Clap Provocation Test in Psychogenic Nonepileptic Seizures
To explore the clinical value of the sudden clap provocation test in the differential diagnosis between epileptic seizures and psychogenic non-epileptic seizures, so as to provide a new strategy for rapid, low-cost differential…
- Trial name
- PNES ACPT (NCT07742709)
- Testing
- Abrupt Clap Provocation Test
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Functional Seizures, Convulsion, Non-Epileptic
A Multi-site Feasibility Clinical Trial of Retraining and Control Therapy (ReACT), a Mind and Body Treatment for Pediatric Functional Seizures
The purpose of this study is to assess the feasibility of conducting a future fully powered multi-site efficacy Randomized Controlled Trial (RCT) comparing two treatments for pediatric functional seizures (FS).
- Trial name
- NCT05819268
- Testing
- ReACT, CATCH-IT
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Convulsion, Non-Epileptic
Automated Identification of Psychogenic Nonepileptic Seizures
A retrospective validation study of a post-processing method intended to identify psychogenic nonepileptic seizures
- Trial name
- NCT03013348
- Testing
- Brain Sentinel's sEMG Post-processing algorithm
- Volunteers
- 104 people
- Sponsor
- Brain Sentinel
Seizures, Seizure Disorder
Modulating Movement Intention Via Cortical Stimulation
The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies.
- Conditions
- Seizures, Seizure Disorder, Psychogenic Movement Disorder
- Trial name
- NCT03233399
- Testing
- rTMS of left or right angular gyrus (AG) or frontal cortex (FC), Anodal tDCS of left or right AG or FC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dissociative Seizures, Functional Seizures
Assessing the Impact of Brief CBTi on Dissociative Seizures: SCED
Some people experience a temporary change in behaviour and consciousness, that often involves a collapse and/or shaking limb movements. These are referred to as 'Dissociative seizures'.
- Conditions
- Dissociative Seizures, Functional Seizures, Psychogenic Nonepileptic Seizures, Insomnia
- Trial name
- CBTi 4 DS:SCED (NCT06145971)
- Testing
- brief Cognitive Behavioural Therapy for Insomnia (bCBTi)
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- University of Glasgow
Biomarkers in Seizures
Inflammatory Biomarkers in Seizure
1. Evaluation of the role of TRAIL and MCP-2 in differentiation between epileptic seizure and psychogenic non-epileptic seizure. 2. Possible role to predict the prognosis of patients with epileptic seizure
- Trial name
- seizure (NCT05556109)
- Testing
- Inflammatory serum biomarkers
- Volunteers
- 90 people
- Sponsor
- Assiut University
EEG, Psychogenic Non Epileptic Events
Comparison of Efficacy Between Suggestion Method During Video EEG Recording by Verbal Suggestion in Isolation and Verbal Suggestion Along With Cotton Swab or Tuning Fork for Inducing the Paroxysmal Event in Children Aged 5 to 18 Years With Suspected Psychogenic Nonepileptic Events
In this study we are going to compare efficacy between suggestion method during video EEG recording by verbal suggestion in isolation and verbal suggestion along with cotton swab or tuning fork for inducing the paroxysmal event…
- Trial name
- NCT03551431
- Testing
- Video EEG with verbal suggestion
- Volunteers
- 25 people
- Sponsor
- All India Institute of Medical Sciences
Dissociative Seizures
Cognitive Behavioural Therapy in Dissociative Seizures
The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater…
- Trial name
- NCT00688727
- Testing
- CBT, Standard Care
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Functional Neurological Symptom Disorder, Functional Seizures
Accelerated TMS for Seizure-Type Functional Neurologic Disorders
The purpose of this project is to assess the feasibility, tolerability, and preliminary efficacy of using an accelerated, intermittent theta burst stimulation (a-iTBS-rTMS) protocol targeting the left dorsolateral prefrontal…
- Trial name
- FND-seiz (NCT07059325)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Epilepsy, Motor Partial, Psychogenic Seizures
Detecting PNES With Single-channel sEMG
This is a prospective, comparative, multicenter study of subjects being admitted for standard of care therapy in Epilepsy Monitoring Units in the Veteran's Affair (VA) Medical Centers.
- Trial name
- NCT03313362
- Testing
- SPEAC System, video EEG
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- Brain Sentinel
Psychogenic Nonepileptic Seizures
Video-EEG Features of Adult Patients With Psychogenic Nonepileptic Seizures
This completed retrospective observational study evaluated adult patients diagnosed with psychogenic nonepileptic seizures (PNES) who underwent video-EEG monitoring.
- Trial name
- NCT07521761
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Convulsion, Non-Epileptic
Treatment Outcomes of ReACT for PNES
This research study is examining the effects of Retraining and Control Therapy (ReACT; an intervention focused on changing behaviors and thoughts) for psychogenic non-epileptic seizures (PNES, episodes resembling epileptic…
- Trial name
- NCT02801136
- Testing
- ReACT, Supportive Therapy
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Nonepileptic Seizures
Treating Non-epileptic Seizures Using Magnetic Brain Stimulation
The purpose of this study is to investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) - a form of non-invasive brain stimulation - to decrease the frequency of psychogenic non-epileptic seizure…
- Trial name
- NCT02796924
- Testing
- MagStim Rapid2 Transcranial Magnetic Simulation
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Psychogenic Non-epileptic Seizures, Motivational Interviewing
Motivational Interviewing to Enhance Adherence of Patients With Psychogenic Non-epileptic Seizures
All subjects will attend an initial clinic visit with the neuropsychiatrist and epileptologist. At the end of this visit, those subjects randomized to motivational interviewing will be questioned using standardized motivational…
- Trial name
- NCT02598076
- Testing
- motivational interviewing, standard psychotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Psychogenic Non-Epileptic Seizure
TMS vs Conventional Therapy for the Treatment of Functional Neurological Non Epileptic Seizure Disorder
The aim of the study is to compare the effect of Transcranial Magnetic Stimulation (TMS) versus treatment with selective serotonin reuptake inhibitors (SSRIs), in patients with diagnosis of Functional Neurological Non Epileptic…
- Trial name
- NCT05241366
- Testing
- Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Psychogenic Nonepileptic Seizures (PNESs), Post Traumatic Stress Disorder PTSD
Treatment for Psychogenic Nonepileptic Seizures and Post-traumatic Stress Disorder Using Prolonged Exposure Therapy (PE) or Psychoeducation for PNES
An outpatient randomized controlled clinical trial conducted at the Northeast Regional Epilepsy Group's PNES Program, involving mental health clinicians certified in PE and trained in administering PsychoEd.
- Trial name
- PNES (NCT07344766)
- Testing
- imaginal and in vivo exposure, psychoeducation for psychogenic nonepileptic seizures
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Northeast Regional Epilepsy Group
Psychogenic Seizure, Epilepsy, Temporal Lobe
Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback
This study investigates whether the sense of agency is sensitive to self-regulation by means of EEG-based neurofeedback. During neurofeedback, the brain activity in response to a motor task is recorded in real-time and displayed…
- Conditions
- Psychogenic Seizure, Epilepsy, Temporal Lobe, Health, Subjective
- Trial name
- NF-Agency (NCT05214833)
- Testing
- Real Neurofeedback
- Where
- Switzerland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Psychogenic Nonepileptic Seizures, Psilocybin
Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures
Psychogenic non-epileptic seizures (PNES) are functional paroxysmal motor disorders that may be clinically suggestive of epilepsy but are not associated with the electroencephysiological and electroencephalographic changes of…
- Trial name
- CRIPSY (NCT06647056)
- Testing
- Psilocybin, MRI
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Epilepsy, Dissociative Seizures
Stress and Seizures - Can a Brief Self-help Book Help?
Background: Epilepsy and nonepileptic attack disorder (NEAD) are chronic conditions that cause many patients to experience a great degree of stress in their everyday lives.
- Trial name
- NCT02465047
- Testing
- Self-help booklet
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Convulsion, Non-Epileptic, Conversion Disorder
Treatments for Psychogenic Nonepileptic Seizures (NES)
The investigators propose that treatment of the comorbid disorders (depression, anxiety, and impulsivity) with sertraline in patients with lone psychogenic nonepileptic seizures (NES), will result in a decreased number of NES.
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NES (NCT00159965)
- Testing
- sertraline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital