Clinical trials: Psychological Disorders
Posttraumatic Stress Disorder (PTSD)
Brain Imaging of Psychotherapy for Posttraumatic Stress Disorder (PTSD)
The investigators are seeking people who have been exposed to a traumatic event in the past and have symptoms of posttraumatic stress disorder (PTSD) currently.
- Trial name
- NCT01507948
- Testing
- Prolonged exposure
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- Stanford University
Obsessive Compulsive Disorder
Genetics of Obsessive-Compulsive Disorder
The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition…
- Trial name
- NCT00001548
- Where
- United States
- Volunteers
- 1,067 people
- Sponsor
- National Institute of Mental Health (NIMH)
Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia
Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial
The goal of this clinical trial is to learn whether guanfacine or cromolyn sodium can improve symptoms and physical functioning in adults with Postural Orthostatic Tachycardia Syndrome (POTS).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia, Orthostatic Intolerance, Autonomic Nervous System Diseases
- Trial name
- DBPOTS (NCT07757555)
- Testing
- Guanfacine (GFC), Cromolyn Sodium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
ADHD
Metacognitive ADHD Telehealth Intervention for Work-performance Enhancement (Work-MATE)
Adults with Attention-deficit hyperactivity disorder (ADHD) experience poor occupational performance at work compare to adults without ADHD, manifested at tendencies toward unemployment, job instability, work accidents, and…
- Trial name
- NCT05270226
- Testing
- The Metacognitive ADHD Telehealth intervention for Work-performance Enhancement (Work-MATE)
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Sara Rosenblum
PARKINSON DISEASE (Disorder)
Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease
This study is a Phase III multicentric randomized controlled trial with parallel group design and waiting list in patients that have an indication to undergo intestinal L-Dopa + entacapone (Lecigon®) under the existing indication…
- Trial name
- INITIATE-LECIG (NCT07151378)
- Testing
- LECIG (levodopa, carbidopa, entacapone intestinal gel), Best oral medication
- Where
- 7 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Substance-Related Disorders
GHB Withdrawal Symptoms and Effectiveness of Treatment With Lorazepam Versus Pentobarbital - 1
Gamma hydroxybutyrate (GHB) is a powerful central nervous system depressant. The number of individuals seeking treatment for GHB abuse has been steadily increasing in the United States.
- Trial name
- NCT00123578
- Testing
- Lorazepam, Pentobarbital
- Where
- United States
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment (MCI), Ageing
Exploring and Evaluating the Impact of 'Refresh and Reconnect!'
Dementia and mild cognitive impairment are a rising concern for the ageing population in Singapore, leading to diminished quality of life and health outcomes.
- Conditions
- Mild Cognitive Impairment (MCI), Ageing, Mild Dementia, Well-being
- Trial name
- ReCognition (NCT06805578)
- Testing
- Heritage art programme
- Where
- Singapore
- Volunteers
- 108 people
- Sponsor
- Duke-NUS Graduate Medical School
Substance Abuse, Cognitive Dysfunction
Aerobic Exercise for Cognitive Functioning in Patients With Substance Use Disorder
Impaired cognitive function is common among patients with substance use disorder (SUD). This is particularly related to executive functions (EF), which includes abilities like decision-making, consequence analysis and…
- Trial name
- SO_CogEx (NCT05324085)
- Testing
- High-intensity interval training, Treatment as usual
- Where
- Norway
- Volunteers
- 84 people
- Sponsor
- St. Olavs Hospital
Alzheimer's Disease
Open Label Study of Isotretinoin in Mild to Moderate Alzheimer's Disease
This is an open label study of isotretinoin, a medication which is FDA approved for treatment of other conditions to determine initial safety in Alzheimer's disease.
- Trial name
- NCT01560585
- Testing
- Isotretinoin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University Hospitals Cleveland Medical Center
Social Isolation, Depression
Discharge Functional Status and Rehospitalization in the Elderly
The DC PROMIS Study (also known as the Discharge Patient Reported Outcomes Measurement Information System Study) is a study to see the effect of patients' social, physical and mental function on their health after hospital…
- Conditions
- Social Isolation, Depression, Anxiety, Debility
- Trial name
- DC PROMIS (NCT02041585)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Older Adults, Cognitive Impairment
Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment
Patients with cognitive decline are frequently comorbid with sleep disorders which may in turn aggravate cognitive decline. Sedative dose dexmedetomidine improved sleep quality but incresed bradycardia and hypotension; low dose…
- Conditions
- Older Adults, Cognitive Impairment, Sleep Disorders, Dexmedetomidine
- Trial name
- NCT07610343
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Neurocognitive Disorders, Postoperative Delirium
Creatine and Perioperative Brain Health
The overall goal of this study is to explore the effects of perioperative oral creatine supplementation on cognitive function and physiological responses to surgery in older adults.
- Conditions
- Neurocognitive Disorders, Postoperative Delirium, Postoperative Outcomes
- Trial name
- CREATE (NCT07310043)
- Testing
- Creatine monohydrate
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mood Disorders
Anergia-anhedonia by Lithium-induced Phosphorus Diabetes
Lithium (Li+) is prescribed to 1‰ of the French population (~ 60,000 patients). More than half of patients describe subjective symptoms linked to Li+ (SSL) similar to those of chronic fatigue syndrome: muscle weakness…
- Trial name
- ALIPo-D (NCT06111664)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Postoperative Delirium, Cognitive Impairment
Predictive Efficacy of Ratio of Median Frequency to Spectral Edge Frequency Used in the Depth of Anaesthesia Monitoring on Post-operative Cognitive Functions
The primary objective of this observational study is to evaluate the effectiveness of preoperative anaesthesia depth monitoring parameters in predicting postoperative cognitive functions in non-cardiac adult patients.
- Trial name
- NCT06644209
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Ankara University
Psychiatric Disorders
Influence of Oxytocin on the Startle Reflex and on Its Modulation
Oxytocin (OXT) is currently regarded as a crucial neuropeptide in the mediation of various human social behaviors, e.g. social affiliation, social recognition, and the modulation of anxiety, mood, and aggression.
- Trial name
- NCT01066299
- Testing
- Syntocinon®, inactive nasal spray
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Schizophrenia
The Hi-tACS on Cognitive Function in Patients With Schizophrenia
This study is a double-blind, randomized, controlled intervention study aimed at exploring whether high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive impairment in patients with…
- Trial name
- NCT06470516
- Testing
- high-frequency transcranial alternating current stimulation
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Schizophrenia, Bipolar Disorder
Indicated Prevention of Psychotic Disorders With Low-dose Lithium
This study investigates the neuroprotective properties of low-dose lithium in young individuals at ultra-high risk of developping a first psychotic episode.
- Conditions
- Schizophrenia, Bipolar Disorder, Psychotic Disorders
- Trial name
- NCT00202306
- Testing
- lithium carbonate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Eating Disorders, Anorexia Nervosa
A Clinical Trial Into the Efficacy of rTMS Treatment for Treating Anorexia Nervosa and Bulimia Nervosa
This is a pilot study to test the efficacy of repetitive transcranial magnetic stimulation (rTMS) in treating individuals with Anorexia Nervosa and Bulimia Nervosa.
- Conditions
- Eating Disorders, Anorexia Nervosa, Bulimia Nervosa
- Trial name
- NCT04061304
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba
Post-Traumatic Stress Disorder
Guitars for Vets: Evaluating Psychological Outcome of a Novel Music Therapy
Post traumatic Stress disorder (PTSD) is a common condition for persons who have served in the Armed services during combat or deployment.
- Trial name
- NCT01229904
- Testing
- music therapy with guitar lessons
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- US Department of Veterans Affairs
Consciousness Disorders
Etiologies, Definitive Diagnosis and Patient Outcomes in Altered Level of Consciousness in the Emergency Department
When someone starts acting differently in terms of how alert or awake they are, it can be a tough situation for emergency (ER) department doctors.e exact and definitive etiologies of ALOC that can be intracranial or extracranial.
- Trial name
- NCT06744114
- Testing
- Consciousness in the Emergency Department
- Where
- Pakistan
- Volunteers
- 1 people
- Sponsor
- Superior University
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