Clinical trials: Psychoses
First Episode Psychosis
Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs
Maintaining treatment engagement is critical for first episode psychosis patients to experience gains possible with coordinated specialty care (CSC).
- Trial name
- NCT04005378
- Testing
- CSC Step-down intervention, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwell Health
SCHIZOPHRENIA 1 (Disorder), Simulation Based Learning
Simulation-Based Schizophrenia Training in Nursing Education
This study aims to examine the effect of a schizophrenia scenario-based simulation on nursing students' knowledge, empathy, and caregiving competence. The study uses a single-group pre-test/post-test (quasi-experimental) design.
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Simulation Based Learning, Nursing Students
- Trial name
- NCT07757750
- Testing
- Simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Medipol University
Mental Disorder
Evaluation of Maternal Mental Health Following Ultrasonography Detection of Fetal Congenital Anomalies
The purpose of this study is to evaluate maternal mental health during antenatal and postnatal periods after Ultrasonography diagnosis of fetal anomalies.
- Trial name
- NCT06594952
- Testing
- Questionnaire and Physical Exam
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Schizophrenia
A Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Males
A Phase 1, Single-centre, Double-blind, Placebo controlled Crossover Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Male Participants
- Trial name
- NCT02935725
- Testing
- Low dose AUT00206 800mg, High dose AUT00206 2000 mg, Ketamine
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Autifony Therapeutics Limited
Schizophrenia Spectrum Disorders, Schizophrenia
Safety and Efficacy of Virtual Reality Mindfulness in Patients With Psychosis
This study is to evaluate the safety and efficacy of Virtual Reality Mindfulness in Patients With Psychosis.
- Conditions
- Schizophrenia Spectrum Disorders, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- NCT05784948
- Testing
- Virtual Reality Mindfulness Treatment, Experience relaxing scenery and music
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Anti-Psychotic, Management of Manifestations of Psychotic Disorders
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Cycle Pharmaceuticals Ltd. (Cycle) is developing an oral tablet formulation of Chlorpromazine Hydrochloride and intends to conduct bioequivalence trials to demonstrate its similarity to the RLD.
- Conditions
- Anti-Psychotic, Management of Manifestations of Psychotic Disorders, Treatment of Schizophrenia, Control Nausea and Vomiting
- Trial name
- NCT02943213
- Testing
- Chlorpromazine Hydrochloride
- Where
- South Africa
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cycle Pharmaceuticals Ltd.
Schizophrenia
Schizophrenia and Genetic Counseling
This research is designed to investigate the perceptions and opinions of individuals who either have schizophrenia or who have a family member with schizophrenia, in relation to genetic counseling.
- Trial name
- NCT00111202
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sarah Lawrence College
Schizophrenia, Catatonia
Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia
The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways. The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its…
- Trial name
- NCT02868879
- Testing
- Quantitative multiparametric and functional MRI
- Where
- France
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Common Mental Disorder
Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders
To explore the whole-brain anatomical and functional abnormalities in drug-naive patients with schizophrenia ,drug-naive patients with BD, drug-naive patients with MDD and healthy controls by using a combination of…
- Trial name
- NCT04218981
- Testing
- Antipsychotic drugs, Mood stabilizer, Paroxetine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Schizophrenia
Parallel Effects of Schizophrenia and N-methyl-D-aspartate (NMDA) Antagonism
This study investigates the common features of electrophysiological measures in schizophrenia and effects of NMDA antagonist ketamine in healthy volunteers.
- Trial name
- NCT02675530
- Testing
- ketamine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer Disease, Alzheimer Disease With Delusions
Tau Networks in Psychotic Alzheimer's Disease
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology.
- Conditions
- Alzheimer Disease, Alzheimer Disease With Delusions, Alzheimer Disease With Psychosis
- Trial name
- NCT05847192
- Testing
- [18F]-PI2620 PET scan
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Schizophrenia
Culturally Based Family Therapy for Improving Treatment Outcome for People With Schizophrenia
This study will evaluate the effectiveness of a culturally based family therapy intervention in improving treatment outcome in people with schizophrenia.
- Trial name
- NCT00356317
- Testing
- Culturally informed therapy for schizophrenia (CIT-S), Psychoeducation treatment as usual
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Miami
Nurses, Schizophenia Disorder
The Effectiveness of Combining AR/VR Technology in Virtual Clinical Auditory Hallucinations on the Comprehensive Auditory Hallucination Nursing Competency of Psychiatric Nurses
This study aims to develop and evaluate a Virtual Reality (VR) Auditory Hallucination Program to enhance psychiatric nurses' comprehensive care competence in managing auditory hallucinations among patients with schizophrenia.
- Conditions
- Nurses, Schizophenia Disorder, Hallucinations, Auditory
- Trial name
- NCT06938997
- Testing
- Virtual clinical auditory hallucination solution combining AR/VR technology, Auditory Hallucination Care Video
- Where
- 4 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Psychosis, Food-drug Interaction
KF2022#3-trial: Effect of Tea and Cola Beverage on Absorption of Risperidone Oral Solution
Risperidone is widely used in the treatment of schizophrenia, bipolar disorder, and aggression associated with moderate or severe Alzheimer's dementia.
- Trial name
- KF2022#3 (NCT06218979)
- Testing
- Risperidone oral solution
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Schizophenia Disorder, Schizoaffective Disorder
Study Comparing Patients Taking Olanzapine and Patients Taking Aripiprazole on Learning of Vocational Skills
STUDY PURPOSE: To study whether patients who have schizophrenia or schizoaffective disorder and are randomly assigned to switch to aripiprazole prior to participation in a brief vocational skills training (VST) will have improved…
- Trial name
- NCT00223418
- Testing
- aripiprazole
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Schizophrenia, Clozapine
The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia
The goal of this research is hoping to combine traditional Chinese medicine medication and find out how to solve clozapine-induced hypersalivation, also reduce side-effect, medication compliance, improving life quality, improving…
- Conditions
- Schizophrenia, Clozapine, Hypersalivation, Traditional Chinese Medicine
- Trial name
- NCT01045720
- Testing
- Suo Quan Wan, Wu Lin San
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Schizophrenia
Evaluating Safety, Tolerability and Pharmacokinetic of Multiple Ascending Doses of VV119
This study will consist of 2 parts: Part Ⅰ-in healthy adult subjects, Part Ⅱ-in adult patients with schizophrenia
- Trial name
- NCT06504290
- Testing
- VV119 （in healthy adult subjects）, VV119(in adult patients with schizophrenia)
- Where
- 4 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Schizophrenia
Exploring the Effectiveness of Digital Anti-stigma Therapy on Illness Perception and Perceived Stigma in Patients With Schizophrenia and Their Primary Caregivers
This study aims to investigate the relationship between illness insight, self-stigma in patients with schizophrenia, and the awareness and associated stigma experienced by their families, as well as the predictors of these…
- Trial name
- NCT06563752
- Testing
- Participants will use 3D glasses to view VR educational information, routine care
- Where
- Taiwan
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Schizophrenia, Schizoaffective Disorder
The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia
It has been suggested that patients with schizophrenia smoke in order to produce amelioration of dysfunctional dopaminergic pathways allowing them to experience pleasure and satisfaction and overcome anhedonia.
- Trial name
- NCT00373126
- Testing
- transdermal nicotine patch
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association