Clinical trials: Pterygium
Pterygium
Safety and Efficacy of CBT-001 Ophthalmic Solution in Patients With Pterygium
Stage 1: Single Ascending Dose, Safety, Tolerability and Pharmacokinetics (n=24) Stage 2: Multiple Dose, Safety and Efficacy Study with 28-day Dosing and 5 months Followup (n=51)
- Trial name
- Pterygium (NCT03049852)
- Testing
- CBT-001 single dose, Vehicle, CBT-001 Multi-dose
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cloudbreak Therapeutics, LLC
Recurrent Pterygium
Clinical Analysis of Recurrence Patterns Following Conjunctival Autografts for Pterygium Surgery
This study is conducted to evaluate its morphologic reproliferating patterns in patients with pterygium treated with the excision and conjunctival autograft.
- Trial name
- NCT02059837
- Testing
- recurrent pterygium excision and following grafting
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Kyungpook National University Hospital
Pterygium
Bandage Contact Lens and Oral Analgesics Versus Patching and Oral Analgesics for Pain Following Pterygium Surgery
The purpose of this study is to determine if patching the eye or a bandage contact lens along with Tylenol #3 is more effective for pain control following pterygium surgery.
- Trial name
- NCT01249235
- Testing
- Patch or bandage contact lens
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Pterygium
Efficacy of Autologous Fibrin Glue in Pterygium
Pterygium is wing-shaped, vascular, fleshy growth that originates on the conjuntiva and that can spread to the corneal limbus and beyond The surgical exeresis with autologous conjunctival autograft technique is the treatment of…
- Trial name
- NCT04151017
- Testing
- Autologous fibrin glue, Suture
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pterygium
Role of Sub-Conjunctival Bevacizumab in Post Pterygium Excision Management
A pterygium is a fibrovascular growth originating from the conjunctiva that grows onto the surface of the cornea. Frequently, these pterygia will recur even after surgical resection.
- Trial name
- NCT01736449
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Arrowhead Regional Medical Center
Pterygium, Pain
Effect of Bromfenac on Pain Related to Pterygium Surgery
To evaluate the efficacy and ocular safety of bromfenac ophthalmic solution (bromfenac) 0.1% dosed twice daily for the treatment of ocular inflammation and pain after pterygium excision with amniotic membrane transplantation(AMT).
- Trial name
- NCT04022811
- Testing
- 0.1% bromfenac
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Pterygium
Intralesional Ranibizumab on Pterygium Vascularity, Size and Recurrence Rate: a Pilot Study
The purpose of this study is to evaluate the pterygium vascularity and size before and after intralesional ranibizumab injection and to evaluate its recurrence rate following pterygium excision surgery.
- Trial name
- NCT02342392
- Testing
- ranibizumab
- Volunteers
- 36 people
- Sponsor
- Universiti Sains Malaysia
Recurrent Pterygia
Amniotic Membrane Associated With Conjunctival Autograft Versus Conjunctival Autograft for Recurrent Pterygia
The purpose of this study is to compare amniotic membrane associated with conjunctival autograft versus conjunctival autograft alone in the treatment of recurrent pterygia.
- Trial name
- NCT00802620
- Testing
- Conjunctival autograft versus conjunctival autograft treatment for recurrent pterygia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Recurrent Pterygium
Conjunctival Autograft or Limbal Conjunctival Autograft for Recurrent Pterygium Using Mitomycin C
The purpose of this randomized clinical trial is to compare the efficacy and safety of intraoperative mitomycin C(MMC) combined with limbal conjunctival autograft(LCAG) or conjunctival autograft(CAG) for recurrent pterygium…
- Trial name
- NCT04463901
- Testing
- Pterygium excision, Intraoperative mitomycin C, Conjunctival autograft
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-sen University
Pterygium
Treatment of Primary Type I Pterygia With Argon Laser
Introduction: Pterygium is a wing shape degenerative and hyperplastic growth of the bulbar conjunctiva extending onto the cornea, most commonly on the nasal side. Management of pterygium can be medical, surgical or combined.
- Trial name
- NCT03485001
- Testing
- Argon Laser Treatment
- Where
- Mexico
- Volunteers
- 16 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Pterygium, Cataract
Effect of Pterygium Excision on Intraocular Lens Power Calculation for Subsequent Cataract Operation
Pterygium is known to induce with-the-rule astigmatism. Excision of pterygium will steepen the cornea and reduce corneal astigmatism.
- Conditions
- Pterygium, Cataract, Astigmatism
- Trial name
- NCT00563667
- Testing
- pterygium excision
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Hospital Authority, Hong Kong
Primary Pterygium
The Effects of Primary Pterygium on Contrast Sensitivity Preoperatively and Postoperatively
Pterygium is the growth of conjunctival tissue onto the cornea, usually from the nasal quadrant of the cornea.Visual acuity may be reduced due to direct invasion of the visual axis or astigmatism induced by the pterygium.
- Trial name
- NCT03406390
- Testing
- Pterygium surgery
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Human Papilloma Virus Infection, Pterygium
Prevalence of HPV-associated Eye Infection and Cytokine Levels in Tears From Patients Diagnosed With Pterygium
Prevalence of HPV-associated eye infection and cytokine levels in tears from patients diagnosed with pterygium
- Trial name
- NCT04117386
- Testing
- HPV genotyping assay using HPV GenoArray Diagnostic Kits (Hybribio Ltd., Sheung Wan, Hong Kong), Bio-Plex® 200 system (Bio- Rad, Hercules, CA)
- Where
- Thailand
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Glaucoma, Pterygium
Ologen (OculusGen)-Glaucoma and Pterygium Historical Control Study in China Beijing Hospital
The purpose of this study is to determine whether the OculusGen Collagen Matrix is effective and safe to implant as an aid of glaucoma and pterygium surgeries.
- Trial name
- NCT00320762
- Testing
- OculusGen Biodegradable Collagen Matrix Implant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Pro Top & Mediking Company Limited
Recurrent Pterygium
Subconjunctival Bevacizumab and Recurrent Pterygium
A study to research whether subconjunctival bevacizumab injection may potentially suppress neovascularization in pterygium, retarding and decreasing the size of recurrent pterygium.
- Trial name
- BRP (NCT01744756)
- Testing
- Bevacizumab
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Instituto de Olhos de Goiania
Diabetic Retinopathy, Proliferative Vitreoretinopathy
Molecular Taxonomy of Surgically-harvested Ocular Tissues Defined by Single-cell Transcriptomics
The surgically-harvested eye tissue (ie. vitreous-retinal proliferative membrane, outflow pathway, retinas, and pterygium) is a complex tissue responsible for maintaining intraocular homeostasis or mediating ocular pathogenesis.
- Conditions
- Diabetic Retinopathy, Proliferative Vitreoretinopathy, Pterygium, Glaucoma
- Trial name
- Eyesinglecell (NCT04682054)
- Testing
- ocular surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pterygium
Comparison Between Sutureless and Glue Free Versus Sutured Limbal Conjunctival Autograft in Primary Pterygium Surgery
Pterygium is a common ocular pathology facing ophthalmologists that has varied surgical management techniques and high rate of post-operative recurrence.
- Trial name
- NCT02009072
- Testing
- Sutureless and glue free limbal conjunctival autograft, Sutured limbal conjunctival autograft
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Shaaban Elwan
Recurrent Pterygium
Bevacizumab Injection for Recurrent Pterygium
Blockade of vascular endothelial growth factor (VEGF) with bevacizumab has been used to treat abnormal vascular conditions of the anterior segment of the eye.
- Trial name
- NCT02007174
- Testing
- Bevacizumab, Medical Treatment, Argon laser treatment
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Pterygium
Subconjunctival Injection of Triamcinolone Acetonide and Limited Peritomy During Pterygium Excision
Pterygium is characterized by encroachment of a fleshy fibrovascular tissue from the bulbar conjunctiva on to the cornea. Although previously thought to be a solely degenerative disease, a new evidence has demonstrated the role of…
- Trial name
- NCT03377348
- Testing
- intraoperative subconjunctival injection of triamcinolone acetonide and limited peritomy during bare scleral pterygium excision
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Pterygium
Comparison of Glue With Sutures for Pterygium Surgery
Pterygium excision surgery involves excising the abnormal growth from the cornea and filling the defect with a conjunctival (white of the eye) graft from the superior part of the eye.
- Trial name
- NCT00326560
- Testing
- Pterygium excision and conjunctival autograft
- Where
- New Zealand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wellington Hospital