Clinical trials: Pulmonary Consolidation
Acute Myeloid Lukemia
Ponatinib for FLT3-ITD Acute Myelogenous Leukemia
This project is part of a joint ALFA and GOELAM strategy aiming to improve the survival of patients with newly diagnosed Acute Myeloid Leukemia (AML) aged 18-70 years.
- Trial name
- PONATINIB-AML (NCT02428543)
- Testing
- Ponatinib and Cytarabine
- Where
- 37 sites in France
- Volunteers
- 49 people
- Sponsor
- Versailles Hospital
Mantle Cell Lymphoma
Bortezomib After Combination Chemotherapy, Rituximab, and an Autologous Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma
This randomized phase II trial studies how well bortezomib works when given after combination chemotherapy, rituximab, and an autologous stem cell transplant in treating patients with mantle cell lymphoma.
- Trial name
- NCT00310037
- Testing
- bortezomib
- Where
- 48 sites in United States
- Volunteers
- 151 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Multiple Myeloma
UARK 2003-33, Total Therapy III
There have been two previous Total Therapy studies for multiple myeloma (MM) at the Myeloma Institute for Research and Therapy (MIRT): Total Therapy I (from 1989 through 1994) and Total Therapy II (from 1996 to 2004).
- Trial name
- NCT00081939
- Testing
- Velcade, Thalidomide
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- University of Arkansas
Multiple Myeloma
A Phase III Trial on the Effect of Elotuzumab in VRD Induction /Consolidation and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma
Trial in patients with newly diagnosed myeloma to evaluate the effect of elotuzumab in induction and consolidation therapy with bortezomib/lenalidomide/dexamethasone and in lenalidomide maintenance treatment
- Trial name
- GMMG-HD6 (NCT02495922)
- Testing
- elotuzumab, Lenalidomide, Bortezomib
- Where
- 68 sites in Germany
- Volunteers
- 564 people
- Sponsor
- University of Heidelberg Medical Center
Memory Consolidation
26 Weeks' Dietary Supplementation With DHA- and EPA-enriched Oils on Memory Consolidation in Healthy Adults
The purpose of this study is to investigate the effects of EPA- and DHA-enriched omega-3 polyunsaturated fatty acid dietary supplements on overnight verbal and visual memory consolidation as well as morning alertness before and…
- Trial name
- NCT03592251
- Testing
- EPA-rich, DHA-rich
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Hodgkin Lymphoma, Adult, Relapsed Hodgkin's Disease, Adult
RWE of Brentuximab Vedotin Consolidation in Patients With RR HL Who Receive Salvage Chemotherapy and ASCT
This is a multicenter, observational real world study with prospective follow up that will evaluate the treatment approach in patients with relapsed/refractory cHL who undergo ASCT in Argentina.
- Conditions
- Hodgkin Lymphoma, Adult, Relapsed Hodgkin's Disease, Adult, Refractory Hodgkin Lymphoma
- Trial name
- NCT04776265
- Testing
- Evaluation of therapeutical approach after ASCT
- Where
- 15 sites in Argentina
- Volunteers
- 100 people
- Sponsor
- Grupo Argentino de Tratamiento de la Leucemia Aguda
Leukemia, Myelodysplastic Syndromes
Combination Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00003602
- Testing
- cytarabine, etoposide, idarubicin
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Riverside Haematology Group
Locally Advanced Rectal Cancer (LARC)
XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients
This is a phase II, multicenter, randomized (2:1) controlled, clinical trial to evaluate the preliminary efficacy and safety of consolidation chemotherapy (XELOX) plus dostarlimab after standard long-course CRT (ARM A) compared…
- Trial name
- IMMUNOSTAR (NCT07381777)
- Testing
- XELOX (Capecitabine and Oxaliplatin), Dostarlimab
- Where
- 30 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
Stage III Non-small Cell Lung Cancer
Study of Tislelizumab for Locally Advanced Non-Small Cell Lung Cancer Following Neoadjuvant Chemotherapy Plus Tislelizumab ± Bevacizumab and Definitive Concurrent Chemoradiation Therapy
The phase II Study is to explore the efficacy and safety of Tislelizumab as consolidation therapy in patients with locally advanced non-small cell lung cancer who have not progressed following neoadjuvant chemotherapy plus…
- Trial name
- NCT05468242
- Testing
- Neoadjuvant chemo-immunotherapy, Bevacizumab, Radiotherapy
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-sen University
Memory Impairment, Amnesia
Sedation and Memory Consolidation
The study of plasticity processes, in particular, memory, is one of the fundamental directions in anesthesiology. To date, there are different views on the impact of sedation and anesthesia on memory.
- Conditions
- Memory Impairment, Amnesia, Recall, Recognition
- Trial name
- NCT05045170
- Testing
- Influence of propofol sedation on memory consolidation and 'working memory', Influence of dexmedetomidine sedation on memory consolidation and 'working memory', Influence of spinal anesthesia on memory consolidation and 'working memory'
- Where
- Russia
- Volunteers
- 81 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Parkinson Disease, Aging
Role of Sleep on Motor Learning in Parkinson's Disease and Healthy Older Adults
People with Parkinson's disease (pwPD) often present difficulty consolidating newly learned skills into long-term memory. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted…
- Trial name
- TARGET-SLEEP (NCT04144283)
- Testing
- NAP, WAKE
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Lung Cancer, Wedge Resection
Wedge Resection for Ground-glass Opacity-featured Lung Cancer (ECTOP-1020)
This is a clinical trial from the Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1020. The goal of this clinical trial is to confirm the therapeutic effect of Wedge resection for ground-glass…
- Conditions
- Lung Cancer, Wedge Resection, Ground-glass Opacity
- Trial name
- NCT06102161
- Testing
- Wedge resection
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Fudan University
Acute Myeloid Leukemia
Induction Therapy for Patients With FLT3 Mutated Acute Myeloid Leukemia
This is a pilot study designed to identify the effect of daunorubicin-cytarabine liposome (CPX-351) in combination with a FLT3-inhibitor (midostaurin) as induction and consolidation therapy for patients with high-risk FLT3…
- Trial name
- NCT04982354
- Testing
- CPX-351, Midostaurin, Busulfan
- Where
- United States
- Sponsor
- Guenther Koehne
Acute Lymphoblastic Leukemia, Adult B-Cell
CD19 CAR-T Consolidation Therapy for Acute Lymphoblastic Leukemia
This is a single-arm, open-label, single-center, phase I/II study to determine the safety and efficacy of CD19 CAR-T(ssCART-19) combined with autologous T cells engineered to express CD19, namely CD19+ feeding T cells (FTCs), as…
- Trial name
- NCT03984968
- Testing
- ssCART-19 cells combined with CD19+ feeding T cells (FTCs) infusion
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Extensive Stage Lung Small Cell Carcinoma
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
This phase II/III trial compares the effect of adding radiation therapy to the usual maintenance therapy with atezolizumab versus atezolizumab alone in patients who have already received atezolizumab plus chemotherapy for the…
- Trial name
- NCT04402788
- Testing
- Atezolizumab, Biospecimen Collection, Computed Tomography
- Where
- 411 sites in United States
- Volunteers
- 138 people
- Sponsor
- National Cancer Institute (NCI)
Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy
Activating mutations in the fms like tyrosine kinase 3 (FLT3) gene are observed in approximately 30% of patients with newly diagnosed acute myeloid leukemia (AML).
- Trial name
- HOVON 156 AML (NCT04027309)
- Testing
- Gilteritinib, Midostaurin
- Where
- 193 sites in Australia, Austria and 11 more
- Volunteers
- 777 people
- Sponsor
- Stichting Hemato-Oncologie voor Volwassenen Nederland
Small Cell Lung Cancer Limited Stage
Study of Toripalimab for Limited-Stage Small Cell Lung Cancer Following Concurrent Chemoradiotherapy
The phase II, randomised study is to explore the efficacy and safety of toripalimab as consolidation therapy in patients with limited-stage small cell lung cancer who have not progressed following concurrent chemoradiation therapy
- Trial name
- NCT04418648
- Testing
- Toripalimab
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sun Yat-sen University
Histoplasmosis
Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (Histo-FACT)
The purpose of the study is threefold: 1. Assess the safety and efficacy of a single high-dose intravenous (LAmB 10mg/kg) compared to the SOC daily dosing (3mg/kg) of the same medication for induction therapy in moderate to…
- Trial name
- NCT07261150
- Testing
- LAmB B, Posaconazole, World Health Organization (WHO)-recommended SOC
- Where
- 2 sites in United States, Brazil
- Volunteers
- 664 people
- Sponsor
- University of Minnesota
Patients With Acute Myeloid Leukemia, Patients Receiving Induction/Consolidation Chemotherapy
Genetic Predictive Model Based on Single Nucleotide Polymorphisms in the DNA Repair Pathway and Drug Metabolis/Transport Pharmacogenetics in the Prediction of Response and Treatment Outcomes in Acute Myeloid Leukemia
The main component in the treatment of acute myeloid leukemia (AML) is consist of anthracycline (such as daunorubicin or idarubicin) and cytarabine.
- Trial name
- NCT01106144
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center