Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive
Effect of Positive Airway Pressure Therapy on Hospitalization and Mortality in SDB Patients With Comorbid Chronic Obstructive Pulmonary Disease (COPD) or/and Heart Failure (HF)
The aim of the study is to test the hypothesis that treatment of sleep disordered breathing (SDB) in patients with comorbid chronic obstructive pulmonary disease (COPD) and/or heart failure (HF) with positive airway pressure…
- Conditions
- Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive, Heart Failure
- Trial name
- NCT02923505
- Testing
- polygraphy or polysomnography
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 383 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Open-Label Assessment of the Albuterol Spiromax® Dry Powder Inhaler (DPI)
This is a prospective, open-label, multicenter Phase 3 study evaluating the performance of the Albuterol Spiromax dose counter in patients with a diagnosis of asthma and/or COPD.
- Trial name
- NCT01857323
- Testing
- Albuterol Spiromax®
- Where
- 30 sites in United States
- Volunteers
- 317 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Parkinson Disease, Diabetes Mellitus
Health Indicators and Patient Reported Outcomes. Identification of Significative Items Aimed at Improving Health Care Procceses.
The objective of this study is to identify key indicators in the follow-up of subjects with different pathologies related to both the person's environment, as well as the perception of their health and general quality of life and…
- Conditions
- Parkinson Disease, Diabetes Mellitus, COVID-19, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OUTCOMES (NCT05343962)
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Instituto de Biomecanica de Valencia
Chronic Obstructive Pulmonary Disease (COPD)
The Efficacy and Safety of Salmeterol/Fluticasone Propionate vs Atropium/Albuterol in Patients COPD
To determine the efficacy and safety of Salmeterol/Fluticasone Propionate 50/500ug BID vs Ipratropium/Albuterol 36/206ug QID in Chinese patients with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT01243788
- Testing
- Salmeterol/Fluticasone Propionate
- Where
- 11 sites in China
- Volunteers
- 450 people
- Sponsor
- Fudan University
Asthma, Chronic Obstructive Pulmonary Disease
Study to Assess the Safety and Efficacy of SelK2 on Airway Responses Following Allergen Challenge in Subjects With Asthma (Part 1) and in Subjects With Chronic Obstructive Pulmonary Disease (Part 2)
This study has two parts. The main purpose of Part 1 of this study will be to examine how safe and effective two doses of SelK2 is on participants with mild asthma.
- Trial name
- NCT04540042
- Testing
- SelK2 (Part 1), SelK2 (Part 2)
- Where
- 2 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- Tetherex Pharmaceuticals Corporation
COPD Exacerbation
High Flow Nasal Cannula vs NPPV in Moderate Chronic Obstructive Pulmonary Disease Exacerbation
For moderate AECOPD(pH<7.35), several guidelines have strongly recommended NPPV as standard therapy, which can reduce the rate of intubation and mortality.
- Trial name
- NCT03014869
- Testing
- High flow nasal cannula
- Where
- China
- Volunteers
- 351 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Pulmonary Disease
Multiorgan Pathology in Chronic Obstructive Pulmonary Disease (COPD)
There is increasing evidence in the literature that COPD should not be considered as a localised pulmonary disorder but as a systemic disease involving pathology in several extra pulmonary tissues.
- Trial name
- NCT00864994
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Top Institute Pharma
COPD
Effects of Laura Mitchell's and Benson Relaxation Technique On Anxiety, Sleep Quality and Fatigue Among COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung condition characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT07635446
- Testing
- Laura Mitchell's Physiological Relaxation Technique., Benson Relaxation
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Copd
Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease
This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07285642
- Testing
- Aerobic Exercise (Treadmill Walking), Resistance Exercise (Upper and Lower Limb Strength Training), Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Asthma, Chronic Obstructive Pulmonary Disease
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease
This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Bronchiectasis, Emphysema
- Trial name
- NCT03455686
- Testing
- Hyperpolarized 129Xe MRI
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease
This study examines the potential benefit of a new antibiotic, Solithromycin, for the long-term treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02628769
- Testing
- Solithromycin
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Alpha 1-Antitrypsin Deficiency, Emphysema or COPD
PiMZ Longitudinal Cohort (PiMZ Logic)
Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. Presentations are variable in the heterozygous population, the most predominant genotype being PiMZ.
- Trial name
- NCT06505603
- Where
- 5 sites in United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
COPD, Obesity &Amp; Overweight
The Impact of a Weight Reduction Intervention on Clinical Outcomes in Patients With Obesity and COPD
Obesity and COPD are increasingly common and often coexist, worsening health outcomes such as reduced lung function, exercise capacity, and increased systemic inflammation.
- Trial name
- NCT07159594
- Testing
- Energy restriction
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Chronic Obstructive Pulmonary Disease
pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD
Investigators wish to identify a relationship between substantial changes in carbon dioxide partial-pressure (pCO2), which frequently occur during the transitions from rest to exercise (ΔpCO2 >4 millimeters of mercury [mmHg] from…
- Trial name
- NCT02660437
- Testing
- Pulmonary Rehabilitation program
- Where
- Germany
- Volunteers
- 91 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease
Comparison Between Symbicort® and Prednisolone in COPD
To assess if Symbicort forte Turbuhaler (during two weeks) is as effective as an oral course of prednisolone + Oxis Turbuhaler (during two weeks) for the treatment of an acute exacerbation of Chronic Obstructive Pulmonary Disease…
- Trial name
- SPACE (NCT00259779)
- Testing
- budesonide/formoterol, Prednisolone
- Where
- 37 sites in Denmark, Finland and 3 more
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Aclidinium Bromide for Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-33)
The purpose of this study is to assess the efficacy (effectiveness) and safety of aclidinium bromide doses as compared to placebo in the treatment of moderate to severe chronic obstructive pulmonary disease.
- Trial name
- NCT00891462
- Testing
- Aclidinium bromide
- Where
- 112 sites in United States, Canada
- Volunteers
- 561 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
A Comparison Study Between the Fixed Dose Triple Combination of Fluticasone Furoate/ Umeclidinium/ Vilanterol Trifenatate (FF/UMEC/VI) With Budesonide/Formoterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This is a phase IIIa, randomised, double-blind, double-dummy, parallel group multicenter study evaluating once daily FF/UMEC/VI (100 microgram [mcg]/62.5 mcg/25 mcg) inhalation powder versus twice daily budesonide/formoterol (400…
- Trial name
- NCT02345161
- Testing
- Triple FF/UMEC/VI, Budesonide/Formoterol, Albuterol/salbutamol
- Where
- 159 sites in Bulgaria, China and 13 more
- Volunteers
- 1,811 people
- Sponsor
- GlaxoSmithKline
COPD - Chronic Obstructive Pulmonary Disease, Forward Head Posture
Combined Posture Correction and Resistive Respiratory Muscles Training in COPD With FHP
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP).
- Trial name
- NCT07293429
- Testing
- Resistive inspiratory muscles training, Resistive expiratory muscles training:, Combined resistive inspiratory and expiratory muscles training
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Respiratory Insufficiency, Respiratory Distress Syndrome, Adult
Continuous Positive Airway Pressure (CPAP) Ventilation Using a Novel Full-Face Mask Versus Conventional Helmet
The aim of this study is to compare two methods of delivery of noninvasive mechanical ventilation (NIV). Since patient compliance and mechanical characteristics of the delivery devices are two fundamental variables in the success…
- Conditions
- Respiratory Insufficiency, Respiratory Distress Syndrome, Adult, Chronic Obstructive Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT00944437
- Testing
- Helmet, Full-face mask
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- University of Parma
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