Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Pulmonary Disease, Chronic Obstructive
A Drug Utilisation Post-authorisation Study of New Users of Aclidinium Bromide (Monotherapy or in Combination)
DUS1 and DUS2 are descriptive drug utilisation studies in new users of aclidinium bromide in Europe. The objectives of DUS1 and DUS2 are to describe the characteristics and patterns of use of new users of aclidinium bromide…
- Trial name
- DUS1/DUS2 (NCT03333018)
- Testing
- Aclidinium bromide, Aclidinium bromide/formoterol, Other COPD medication
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 22,155 people
- Sponsor
- AstraZeneca
COPD, Cancer
SELF - BREATHE for Chronic Breathlessness
Semi-structured qualitative interviews will be conducted to understand key factors that would enable / facilitate patients with chronic breathlessness to potentially use an online breathlessness intervention (SELF-BREATHE).
- Conditions
- COPD, Cancer, Heart Failure, Interstitial Disease
- Trial name
- NCT04466020
- Testing
- Qualitative research interviews to be conducted
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College Hospital NHS Trust
Multiple Conditions, Coronary Heart Disease
Improving Monitoring of Patients Receiving Case Management
The UK population is ageing and the likelihood of having a long term health condition increases with age. Three out of every five people over 60 in the UK have a long term condition.
- Conditions
- Multiple Conditions, Coronary Heart Disease, Diabetes, Hypertension
- Trial name
- NCT01597882
- Where
- 2 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- University of Southampton
COPD
Analyse the Correlation Between sEMG and EMGdi
The most significant pathophysiology change of COPD patients is persistent incompletely reversible airflow obstruction and increased lung volume. As a result, the work of breathing(WB) and neural respiratory drive (NRD)increased.
- Trial name
- NCT03268616
- Testing
- inspiratory threshold load device and NPPV
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Emphysema or COPD
Post-Market BTVA Registry
Bronchoscopic thermal vapor ablation using Uptake Medical Technology Inc.'s InterVapor System is indicated for treatment of patients with heterogeneous upper lobe emphysema.
- Trial name
- NCT03318406
- Testing
- Bronchoscopic Thermal Vapor Ablation
- Where
- 20 sites in Austria, Germany and 1 more
- Volunteers
- 300 people
- Sponsor
- Uptake Medical Technology, Inc.
Pulmonary Disease, Chronic Obstructive
HandiHaler® vs. Metered Dose Inhaler (MDI) in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Trial to compare the administration technique for HandiHaler® vs. MDI, to compare the learning retention of the administration technique for the HandiHaler® vs. MDI and to compare the ease of use for HandiHaler® vs. MDI
- Trial name
- NCT02172404
- Testing
- Ipratropium metered dose inhaler (MDI)
- Volunteers
- 160 people
- Sponsor
- Boehringer Ingelheim
COPD Exacerbation
NIV - NAVA vs NIV - PS for COPD Exacerbation
Number of Patients: Total no. of patients = 40 patients NIV-PSV group (Group A) = 20 NIV-NAVA group (Group B) = 20 Inclusion criteria a) Patients of Chronic obstructive pulmonary disease with acute hypercapnic respiratory failure…
- Trial name
- NAVA-NICE (NCT02912689)
- Testing
- Neurally Adjusted Ventilator Assist, Pressure support ventilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Chronic Obstructive Pulmonary Disease, Anxiety
Dialogue Aimed at Reducing Anxiety in Patients With Severe COPD
The purpose of this trial is to determine whether a minimal homebased psychoeducative intervention is effective in management of anxiety and dyspnea in patients with severe chronic obstructive pulmonary disease.
- Trial name
- DIACOL (NCT02366390)
- Testing
- Psychoeducative intervention
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Nordsjaellands Hospital
COPD (Chronic Obstructive Pulmonary Disease)
HFNC Versus NIV in Hypercapneic COPD Patients
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Trial name
- NCT07854210
- Testing
- high flow nasal cannula, non invasive ventilation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Shehta
Dyspnea, Chronic Obstructive Pulmonary Disease
The Effect of Music Therapy on Dyspnea Severity and Vital Signs
This study aims to investigate the effect of music therapy on dyspnea severity and quality of life indicators in patients with Chronic Obstructive Pulmonary Disease (COPD) admitted to the intensive care unit.
- Trial name
- NCT06358235
- Testing
- Music Therapy, No Music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Suleyman Demirel University
Chronic Obstructive Pulmonary Disease
Expression of miR-204 and Consequences on Capillarization in Limb Muscles of Patients With COPD
Limb muscle dysfunction, characterized by loss of capillaries, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality.
- Trial name
- NCT02903043
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laval University
Pulmonary Disease, Chronic Obstructive
Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and Eosinophilia Among Primary Care Patients
Early diagnosis and appropriate treatment for COPD subjects are both critical to minimize the progression of COPD and improve outcomes.
- Trial name
- NCT03018808
- Testing
- Minimal questionnaire, Medical interview, CAT
- Where
- 4 sites in Brazil
- Volunteers
- 800 people
- Sponsor
- GlaxoSmithKline
Parkinson Disease, Diabetes Mellitus
Health Indicators and Patient Reported Outcomes. Identification of Significative Items Aimed at Improving Health Care Procceses.
The objective of this study is to identify key indicators in the follow-up of subjects with different pathologies related to both the person's environment, as well as the perception of their health and general quality of life and…
- Conditions
- Parkinson Disease, Diabetes Mellitus, COVID-19, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OUTCOMES (NCT05343962)
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Instituto de Biomecanica de Valencia
Pulmonary Disease, Chronic Obstructive
Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This study will assess the safety and efficacy of a range of oglemilast doses. The study will be 14 weeks in duration. All patients meeting the eligibility criteria will be randomized to one of three doses of oglemilast or…
- Trial name
- NCT00671073
- Testing
- Oglemilast
- Where
- 47 sites in United States
- Volunteers
- 427 people
- Sponsor
- Forest Laboratories
COPD Exacerbation, Hypercapnia
DUET Versus Standard Interface for Hypercapnic COPD Patients
The goal of this clinical trial is to compare the new asymmetric nasal high flow interface with the conventional high flow nasal cannula in patients with COPD exacerbation.
- Conditions
- COPD Exacerbation, Hypercapnia, COPD
- Trial name
- NCT05829083
- Testing
- Asymmetric nasal cannula - DUET, Conventional nasal high flow cannula
- Where
- 2 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Larissa University Hospital
Chronic Obstructive Lung Disease
A Study to Investigate Small Mobile Stem Cells (SMS) in Moderate to Severe Chronic Obstructive Pulmonary Disease
This study is a phase 1b/2a, open-label, non-randomized, observation of 125 adults, with moderate to severe chronic obstructive pulmonary disease, treated with SORT-COPD (SMS cells).
- Trial name
- SORT-COPD II (NCT07871890)
- Testing
- Stem cells
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- SMSbiotech
COPD
The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients
The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping…
- Trial name
- NCT05585060
- Testing
- the changes of end expiratory lung impedence, the changes of end expiratory lung volume
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD, Hyperinflation
Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Chronic Obstructive Pulmonary disease (COPD) is one of the major clinical entities that causes thousands of deaths every year all over the world and weights a lot on the health care system of every country in terms of direct and…
- Conditions
- COPD, Hyperinflation, Right Cardiac Failure
- Trial name
- NCT01996124
- Testing
- Indacaterol Fumarate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
COPD, Anxiety Disorders
Anxiety and Depression in COPD; Prevalence, Detection and Prognosis
The current cohort study of 300 stable COPD patients aims to assess the following topics: The prevalence of anxiety and depressive disorders in patients with COPD The screening properties of Hospital Anxiety and Depression Scale…
- Conditions
- COPD, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT04427579
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University Hospital, Akershus
Severe Asthma, COPD
K-HEALTH in AIR - Barcelona Pilot - Cohort
The study protocol is part of the European (EU) project "Knowledge for improving indoor AIR quality and HEALTH" (K-HEALTHinAIR, 2022-2026 - registry 101057693), which focuses on enhancing our understanding of how poor indoor air…
- Trial name
- NCT06421402
- Testing
- Air quality monitoring at patient's home, Questionnaires: Baseline & every six months, Lung function Testing: Baseline & every six months & during exacerbations
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
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