Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Lung Diseases, Asthma
Prospective Evaluation of Airways Reactivity
From 1981 to 1991, to characterize the role of allergy and airways responsiveness in modifying growth of lung function in children and young adults in a community-based random population, the Childhood Respiratory Study in East…
- Conditions
- Lung Diseases, Asthma, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00005282
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease (COPD)
Study on the Impact of Decolonization Treatment of Pneumocystis Jirovecii on the Frequency of Acute Exacerbation in COPD
Previous researches have found the common colonization of Pneumocystis jirovecii (Pj) in the airways of people with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07665359
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Where
- 20 sites in China
- Volunteers
- 630 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Obstructive Pulmonary Disease Moderate
Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients
The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days.
- Trial name
- COPD (NCT03020862)
- Testing
- Dietary beetroot juice
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Physiology
Physiopathology of Lower Cortical Activation in COPD Patients: Contribution of Cortical Neuromodulation
Patients with COPD have lower cortical activation and higher cortical inhibitory levels. The purpose of this study is to test the reversibility the lower cortical activation by counterbalancing the increased cortical inhibitory…
- Trial name
- NCT03368703
- Testing
- Anodal transcranial direct-current-stimulation
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- 5 Santé
COPD, Osa Syndrome
Screening and Early Warning of Chronic Obstructive Pulmonary Disease Combined With Sleep Respiratory Disease Based on Medical Internet of Things
Chronic obstructive pulmonary disease (COPD) is a common disease that endangers people's health, causing severe economic and treatment burdens.
- Trial name
- NCT04833725
- Testing
- wearable devices
- Where
- China
- Volunteers
- 680 people
- Sponsor
- Peking University Third Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could reduce the need for endotracheal intubation during hospitalization in patients with an AECOPD and hypercapnia.
- Trial name
- NCT02985918
- Testing
- High-intensity NPPV, Low-intensity NPPV
- Where
- 31 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Obstructive Pulmonary Disease
Acute Exacerbation of Chronic Obstructive Pulmonary Disease Inpatient Registry Study
The purpose of this study is to investigate the demographic characteristics, clinical features, diagnoses and treatments of AECOPD hospitalized patients in China, and disease prognosis and its economic burden.
- Trial name
- AECOPD-IRS (NCT02657525)
- Volunteers
- 7,600 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Pulmonary Disease
Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial
A randomised controlled trial to test the hypothesis that inhaled therapies for chronic obstructive pulmonary disease (COPD) have differential effects on the upper airway microbiome.
- Trial name
- MUSIC (NCT02972476)
- Testing
- Budesonide & formoterol fumarate and Aclidinium bromide, Fluticasone 500 & salmeterol and Aclidinium bromide, Fluticasone 250 & salmeterol and Aclidinium bromide
- Where
- 6 sites in United Kingdom
- Volunteers
- 158 people
- Sponsor
- University of Dundee
Chronic Obstructive Pulmonary Disease (COPD)
TCM Cohort for Elderly COPD
This study evaluates the real-world clinical efficacy of traditional Chinese medicine (TCM) in elderly Chronic obstructive pulmonary disease (COPD) patients and explores syndrome characteristics and their associations with…
- Trial name
- NCT07780682
- Testing
- Traditional Chinese medicine (TCM), Non-traditional Chinese medicine (non-TCM)
- Where
- China
- Volunteers
- 2,386 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
Pulmonary Emphysema
US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study
The purpose of this study is to evaluate the safety of the Biologic Lung Volume Reduction System (BLVR) for patients with advanced emphysema.
- Trial name
- NCT00347659
- Testing
- BLVR System
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Aeris Therapeutics
Cachexia, Chronic Obstructive Pulmonary Disease
Food Reward in Cachexia Induced by Acute or Chronic Disease
To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer or chronic disease.
- Conditions
- Cachexia, Chronic Obstructive Pulmonary Disease, Non-small Cell Lung Cancer, Pancreatic Cancer
- Trial name
- NCT02798003
- Testing
- Functional magnetic resonance imaging (fMRI)
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Maastricht University Medical Center
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD)
Red Blood Cell and Platelet Indices for Predicting Outcomes in Acute Exacerbations of COPD
The purpose of this study is to evaluate if standard, easily accessible blood tests can help doctors predict the severity and outcomes of sudden flare-ups in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD), AECOPD
- Trial name
- NCT07693127
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease (COPD)
Intermittent Hypoxemia, Lung Function Decline, Morbidity, and Mortality in COPD (PROSA Study).
This study aims to analyze if patients with chronic obstructive lung disease who experience a decline of blood oxygen saturation during physical exercise have a disease course different from that of COPD patients who do not…
- Trial name
- PROSA (NCT06265623)
- Testing
- No active intervention, but observational follow-up
- Where
- Germany
- Volunteers
- 148 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pneumonia, Diabetes
Social Incentives to Increase Mobility
This study aims to assess the effectiveness of a social incentive-based gamification intervention to increase physical activity in the 3 months after hospital discharge.
- Conditions
- Pneumonia, Diabetes, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- MOVE IT (NCT03321279)
- Testing
- Social Incentive
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- University of Pennsylvania
Sarcopenic Obesity, COPD
A Prognostic Model for COPD Complicated With Sarcopenic Obesity Based on Bioelectrical Impedance Phase Angle Technology
This study aims to explore the diagnosis, impact, and prognostic factors of COPD complicated with sarcopenic obesity using multi-segment bioelectrical impedance phase angle technology.
- Trial name
- NCT07136246
- Testing
- InBody S10
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
COPD
Regeneration of Bronchial Epithelium During Chronic Obstructive Pulmonary Disease
Airway epithelium integrity is essential to maintain its role of mechanical and functional barrier. Recurrent epithelial injuries require a complex mechanism of repair to restore its integrity.
- Trial name
- EPITHREGENCOPD (NCT02873988)
- Testing
- bronchial epithelial cell culture
- Where
- France
- Volunteers
- 25 people
- Sponsor
- CHU de Reims
Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
The 7-Visit Transition of Care Hospital to Home Intervention: A Pilot Study
New approaches to care transitions must deploy a longer-term and more intensive program that provide an array of services that address underlying social determinants of health (e.g.
- Trial name
- NCT04955405
- Testing
- The seven visit telemedicine protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
COVID-19, Chronic Lung Diseases
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs
This is study is comprised of three approaches. First, the investigators will conduct a retrospective cohort study to determine factors associated with COVID-19 severity and complications and understand COVID-19 outcomes…
- Trial name
- LAUREL (NCT04628039)
- Where
- 2 sites in United States
- Volunteers
- 622 people
- Sponsor
- VA Office of Research and Development
Pulmonary Disease, Chronic Obstructive
Comparing Two Pneumococcal Vaccines in Adults With Chronic Obstructive Pulmonary Disease
Pneumococcal disease is a serious bacterial infection that can affect different parts of the body, including the lungs. People with chronic illnesses, such as chronic obstructive pulmonary disease (COPD), have a greater risk of…
- Trial name
- PNEUMO (NCT00457977)
- Testing
- Pneumovax (PPSV23), Prevnar (PCV7)
- Where
- 18 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Lung Tissue Research Consortium
The LTRC will facilitate histopathological research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the LTRC.
- Trial name
- LTRC (NCT02988388)
- Testing
- Lung biopsy/lobectomy
- Where
- 4 sites in United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.