Clinical trials: Pulmonary Failure
Acute Respiratory Failure, Covid19
Inspiratory Effort in COVID-19
This study aims at assessing esophageal pressure in patients with acute respiratory failure due to COVID-19 undergoing non invasive respiratory support.
- Trial name
- PERSIA (NCT04666246)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Modena and Reggio Emilia
ARDS, Multi-organ Failure
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support
The goal of this project is to find a marker expression that the investigators can use to trace symptom progression and develop a more efficient therapy to enhance ARDS patient survival rate and better post-ICU life quality.
- Trial name
- ARDS (NCT01967602)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure
It's a phase III, prospective, multicenter, randomized controlled trial to evaluate the safety and efficacy of the pulmonary artery denervation (PADN) for heart failure (HF) patients diagnosed with pulmonary hypertension…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Hypertension, Vascular Diseases
- Trial name
- PADN-HF-PH (NCT05824923)
- Testing
- Pulmonary arterial denervation, Guideline-directed medical therapy (GDMT) for heart failure
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Pulnovo Medical (Wuxi) Co., Ltd.
Heart Failure, Pulmonary Disease, Chronic Obstructive
Telehome Monitoring for Chronic Disease Management
People living in rural areas are at increased risk for poor health outcomes due to: long distance to health care facilities, less available health care resources such as primary care and specialty services, transportation…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Hypertension, Diabetes Mellitus
- Trial name
- NCT02035566
- Testing
- Telehome Care Monitoring
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Maryland, Baltimore
Pulmonary Disease, Chronic Obstructive
High-Flow Nasal Oxygen Therapy for Exacerbation of Chronic Pulmonary Obstructive Disease.
High-Flow Nasal Oxygen (HFNO) therapy has never been tested against Noninvasive ventilation, the reference standard therapy for acute exacerbation of chronic obstructive pulmonary disease (COPD), in randomized clinical trials.
- Trial name
- OxyCOD (NCT03488628)
- Testing
- Noninvasive ventilation, High-Flow Nasal Oxygen therapy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
COVID-19, SARS-CoV2 Infection
Awake Prone Positioning in Moderate to Severe COVID-19
The purpose of this study is comparing vital signs between standard care and prone position groups. Standard care will consist of routine clinical care, including any advice to lie in prone position as routinely recommended by…
- Conditions
- COVID-19, SARS-CoV2 Infection, COVID-19 Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
- Trial name
- NCT05083130
- Testing
- a wake prone positioning
- Where
- Vietnam
- Volunteers
- 93 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Respiratory Insufficiency, Ventilator Weaning
Extubation Guided by Bedside Ultrasound
The aging of the global population has led to an increased number of surgical procedures being performed on elderly patients. However, with aging, the main structure and function of the lungs undergo progressive changes involving…
- Conditions
- Respiratory Insufficiency, Ventilator Weaning, Postoperative Complications
- Trial name
- NCT05674812
- Testing
- Multimodal pre-extubation risk assessment in elderly surgical patients
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Lili Jia
Severe Acute Cardiogenic Pulmonary Edema
CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary Edema
To evaluate whether bilevel positive airway pressure more rapidly improves ventilation than continuous positive airway pressure (CPAP) in patients with acute pulmonary edema.
- Trial name
- NCT00213681
- Testing
- Boussignac CPAP - bilevel ventilation support
- Where
- France
- Sponsor
- University Hospital, Rouen
Critical Illness, Heart Failure
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress
Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress.
- Conditions
- Critical Illness, Heart Failure, Sepsis, Ards
- Trial name
- Lift 3 (NCT07634419)
- Testing
- Lift mobile mindfulness, Enlighten Recovery education program
- Where
- 3 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
COPD, Hyperinflation
Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Chronic Obstructive Pulmonary disease (COPD) is one of the major clinical entities that causes thousands of deaths every year all over the world and weights a lot on the health care system of every country in terms of direct and…
- Conditions
- COPD, Hyperinflation, Right Cardiac Failure
- Trial name
- NCT01996124
- Testing
- Indacaterol Fumarate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Liver Transplantation
Hemodynamic Measurements During Liver Transplantation
The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.
- Trial name
- OLT (NCT00682110)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Heart Failure, Copd
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge
The purpose of this study is to determine if medically tailored meals provided for either 2 weeks or 4 weeks (1 meal per day) to a Kaiser Permanente Colorado (KPCO) member after hospital discharge will improve their health.
- Conditions
- Heart Failure, Copd, Liver Failure, Diabetes Mellitus
- Trial name
- NCT04351880
- Testing
- Medically Tailored Meals
- Where
- 2 sites in United States
- Volunteers
- 650 people
- Sponsor
- Kaiser Permanente
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Heart Failure, Pulmonary Disease
Caregiver Outlook: An Intervention to Improve Caregiving in Serious Illness
Informal caregivers provide a majority of care for patients during serious illness. Lack of preparation and completion may leave caregivers less capable of caring for a loved one or making crucial decisions influencing care.
- Conditions
- Heart Failure, Pulmonary Disease, Cancer
- Trial name
- NCT01672294
- Testing
- Preparation and life completion, Attention Control
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- VA Office of Research and Development
Lung Cancer Stage III, EGFR Activating Mutation
Thoracic Radiotherapy Plus EGFR-TKI for Stage III EGFR-mutant Lung Adenocarcinoma
Objective: To investigate the failure patterns, efficacy and safety of thoracic radiotherapy combined with EGFR-TKI in stage III unresectable non-small cell lung cancer harboring EGFR-sensitive mutations.
- Trial name
- NCT07857694
- Testing
- Thoracic radiotherapy, EGFR-TKI
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Laibin People's Hospital
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure
In patients with acute hypoxemic respiratory failure whose diagnosis is not established after initial evaluation, obtaining a histopathological diagnosis may improve the patients' prognosis.
- Trial name
- NCT05754866
- Testing
- Transbronchial lung cryobiopsy, Transbronchial lung biopsy
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Acute Respiratory Failure With Hypoxia
PEEP in Patients With Acute Respiratory Failure
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support.
- Trial name
- NCT04912960
- Testing
- Mechanical ventilation
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Jesus Villar
Acute Heart Failure
Investigating Reduction of aCute heArt Failure Readmission With Lung UltraSound-preliminary Trial
In Switzerland 15% of discharged patients are readmitted within 30 days. Acute heart failure is the leading cause of hospital admission and one of the most frequent reasons for re-admission, mainly because of congestion-driven…
- Trial name
- Pre-IcarUS (NCT04174794)
- Testing
- Lung ultrasound
- Where
- Switzerland
- Volunteers
- 43 people
- Sponsor
- University Hospital, Geneva
Peripheral Artery Disease, Coronary Disease
Evaluation of Patients With Known or Suspected Heart Disease
In this study researchers will admit and evaluate patients with known or suspected heart disease referred to the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI).
- Conditions
- Peripheral Artery Disease, Coronary Disease, Diabetes and Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT00001313
- Where
- 2 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Transplant, Pulmonary Hypertension
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
The purpose of this study is to determine if transseptal extra-corporeal membrane oxygenation (ECMO) can bridge pulmonary hypertension- right heart failure (PH-RVF) patients to lung transplant safely.
- Trial name
- NCT06770023
- Testing
- Protek Solo Transseptal Cannula
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
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