Clinical trials: Pulmonary Function Assessment, active
Chronic Obstructive Pulmonary Disease, Hyperinflation
A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation
The purpose of the study is to evaluate the effect of BGF MDI compared with placebo MDI on cardiac and lung function when administered in participants diagnosed with COPD and hyperinflation.
- Trial name
- ORATOS (NCT07073950)
- Testing
- Budesonide/Glycopyrronium/Formoterol Fumarate, Metered dose inhaler
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 56 people
- Sponsor
- AstraZeneca
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Physical Activities
Changes in Energy Expenditure in Response to Physical Activity in Healthy Adults
This study investigates how short, high-intensity body-weight exercises affect energy use in healthy young adults. The focus is on resting metabolic rate (RMR), total energy expenditure (TEE) and excess post-exercise oxygen…
- Trial name
- VITAL (NCT07529132)
- Testing
- physical activity
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Bialystok
Obesity and Obesity-related Medical Conditions
Assessment of Pulmonary Function in Relation to the Anesthetic Used in Patients Undergoing Bariatric Surgery
It is known that more or less pronounced impairment of pulmonary function occurs after anesthesia. It has been demonstrated in the postoperative period in both patients undergoing general and regional anesthesia, in patients…
- Trial name
- NCT06759623
- Testing
- Different drug type for conduction of general anesthesia
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Asthma (Diagnosis)
Effects of Respiratory Muscle Strength Training in Children With Asthma
Asthma is a common long-term respiratory condition in children. In addition to affecting breathing, asthma may affect physical activity, exercise capacity, daily functioning, and quality of life.
- Trial name
- NCT07880145
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hasan Kalyoncu University
Fibrotic Interstitial Lung Disease
Mechanistic 129 Xe MRI Study to Assess Therapeutic Response in Fibrotic Interstitial Lung Disease
The goal of this observational study is to better understand how treatment affects the lungs of adults (ages 18-80) with fibrotic interstitial lung diseases.
- Trial name
- MASTER-ILD (NCT07786090)
- Testing
- Hyperpolarized 129Xe MRI
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Dr. Grace Parraga
Pulmonary Arterial Hypertension
Cognitive Alterations in Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension (PAH) is a rare chronic disease marked by a pathological and sustained increase in pulmonary artery pressure as a result of structural and functional changes within the pulmonary vasculature.
- Trial name
- COG-PAH (NCT07391228)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alessandra Gorini
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cystic Fibrosis (CF), CFTR-related Disorders
A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis
Sometimes it is very difficult to tell if someone has cystic fibrosis (CF), especially when they have rare CF genes. Without this certainty, they are unlikely to get the correct treatment so their health may be affected.
- Trial name
- ADVANCE-CFTR (NCT07402434)
- Testing
- Rectal Biopsy, Rectal biopsy taken opportunistically during endoscopy procedure for other reasons., Blood test for CFTR Genotyping
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Function Assessment, Disease Free Survival
Pulmonary Watershed Topographic Map Navigation for Lung Nodule Resection
A method of ICG counterstaining localization under target artery occlusion without cutting，It's a new method of localization of small pulmonary nodules.
- Conditions
- Pulmonary Function Assessment, Disease Free Survival, NSCLC, Stage I
- Trial name
- NCT06404164
- Testing
- Wedge resection under watershed analysis method
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Idiopathic Pulmonary Fibrosis, Small Airways Disease
Small Airways Disease Functional Assessment in Idiopathic Pulmonary Fibrosis (SWIFT-IPF)
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, fibrosing, and progressive lung disease of unknown cause, whose incidence increases proportionally from the age of 60. It is characterized by a poor prognosis.
- Trial name
- SWIFT-IPF (NCT07312305)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Milan
Long COVID-19, Post-COVID-19 Syndrome
Effects of a Home-Based Exercise Intervention in Subjects with Long COVID
The current Coronavirus Disease 2019 (COVID-19) pandemic is the most severe health crisis of the 21st century. This is not only due to the deaths caused by the disease.
- Trial name
- NCT06073002
- Testing
- home-based concurrent exercise
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- University of Vienna
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital
Chronic Thromboembolic Pulmonary Hypertension, Physical Disability
Frailty, Physical Capacity and Lung Function in Postoperative Pulmonary Endarterectomy Patients
The goal of this observational and prospective study is to investigate changes in physical performance, lung function, respiratory and peripheral muscle strength in patients during the postoperative period following pulmonary…
- Conditions
- Chronic Thromboembolic Pulmonary Hypertension, Physical Disability, Fragility
- Trial name
- NCT06286891
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Cystic Fibrosis
Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children
This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children with cystic fibrosis (CF).
- Trial name
- BEGIN (NCT04509050)
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 35 sites in United States
- Volunteers
- 210 people
- Sponsor
- Sonya Heltshe
COPD, Health Literacy
Health Literacy, Physical and Cognitive Function, Health-related Behaviors, and Quality of Life in COPD
Health literacy is important for controlling disease progression and living a healthy life with illness. High health literacy is associated with higher cognitive performance and lower health-related quality of life.
- Conditions
- COPD, Health Literacy, Health-Related Behavior
- Trial name
- NCT06497816
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Acute Pulmonary Embolism (PE)
Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters
Echocardiographic Assessment: Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS)…
- Trial name
- NCT07107347
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Lung Neoplasm
Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy
The goal of this observational validation study is to determine the best implementation of fluoroscopic and CT ventilation imaging in patients having non-stereotactic ablative body radiotherapy (non-SABR) radiotherapy for stages…
- Trial name
- VENTURE (NCT06159660)
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- University of Sydney
Non-small Cell Lung Cancer (NSCLC), Cachexia
A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight Loss
Study to investigate the effect of ponsegromab on skeletal muscle mass and physical function in adult participants with non-small cell lung cancer associated cachexia.
- Trial name
- NCT07663630
- Testing
- ponsegromab
- Where
- 7 sites in United States, China
- Volunteers
- 80 people
- Sponsor
- Pfizer
Interstitial Lung Disease
The Effect of Video Game-Based Exercise Training in Patients With Interstitial Lung Disease
The goal of this prospective randomized controlled clinical trial is to evaluate the effects of video game-based physiotherapy and rehabilitation on functional exercise capacity and respiratory parameters in individuals with…
- Trial name
- NCT07167238
- Testing
- Virtual reality exercises, Home exercises
- Volunteers
- 42 people
- Sponsor
- Istinye University