Clinical trials: Pulmonary Nodules, open to volunteers
Pulmonary Nodule, Solitary, Lung Cancer
Pulmonary Nodule Cohort
The aim of this study is to identify the clinical features of pulmonary nodules and establish a cohort to identify biomarkers for lung cancer.
- Trial name
- liquidNodule (NCT04049422)
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Lung Cancer
Research on Early Screening and Diagnosis of Pulmonary Nodules Based on Novel Non-invasive Technologies.
This is a prospective observational study designed to address the clinical challenge posed by the high false-positive rate associated with CT imaging in early lung cancer screening.
- Trial name
- NCT07370077
- Testing
- Employing multi-omics diagnostic approaches to enhance diagnostic efficacy
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Chen KeZhong
Pulmonary Nodules, Nerve Block
Local Anaesthetic Spread and Sensory Block Range of the Retro-superior Costotransverse Ligament Space Block
The aim of this clinical trial is to investigate the effects of local anesthetic diffusion range and sensory block range during retro-SCTLB(retro superior costotransverse ligament space block) and TPVB(thoracic paravertebral…
- Trial name
- NCT07153263
- Testing
- Ultrasound-guided retro-SCTLB, Ultrasound-guided TPVB
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Thoracic Neoplasm, Pulmonary Nodules
Study of Collection and Analysis of Clinical, Anamnestic, Functional, Biological Data Through the Support of Artificial Intelligence to Evaluate the Possibility of Defining a Digital Twin of the Lung (LUCE)
This research study aims to retrospectively and prospectively analyze the clinical, anamnestic, functional, biological data of patients who have performed or will perform non-contrast chest photon count CT.
- Conditions
- Thoracic Neoplasm, Pulmonary Nodules, Non-oncological Pulmonary Pathologies
- Trial name
- NCT07517393
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Pulmonary Nodules
Effect of Technology-Assisted Preoperative Home Exercise on Postoperative Handgrip Strength, Muscle Endurance, and Psychological Distress in Patients With Pulmonary Nodules Undergoing Video-Assisted Thoracoscopic Surgery
This study aims to evaluate the effects of a technology-assisted preoperative home-based exercise program, delivered through a LINE Official Account and LINE BOT, on postoperative hand-grip strength, muscle endurance, and…
- Trial name
- NCT07302217
- Testing
- Technology-Assisted Preoperative Home-Based Exercise Program
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Hydatidiform Mole, Gestational Trophoblastic Neoplasia
Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule
The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A.
- Trial name
- NCT03785574
- Testing
- Follow up, chemotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Pulmonary Nodules, Lung Neoplasms
Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CT
Pulmonary ground-glass nodules (GGNs) are commonly found on chest CT scans. Some stay stable for years, while others slowly or rapidly turn into lung cancer.
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Adenocarcinoma of Lung
- Trial name
- GGN-Trajectory (NCT07647692)
- Testing
- Serial Thin-Slice Chest CT
- Where
- China
- Volunteers
- 4,750 people
- Sponsor
- Peking University People's Hospital
Pulmonary Nodules, Early Stage Lung Cancer (I and II)
Tubeless Strategy for Enhanced Recovery After Sublobar Resection
This is a prospective, randomized controlled clinical trial conducted at a single center. The study aims to evaluate whether a "tubeless" strategy can enhance recovery for patients undergoing minimally invasive thoracoscopic…
- Conditions
- Pulmonary Nodules, Early Stage Lung Cancer (I and II), Thoracoscopic Surgery, Sublobar Resection
- Trial name
- NCT07409129
- Testing
- Laryngeal Mask Airway, Thoracic Paravertebral Block with Local Anesthetic, Non-intubated Anesthesia
- Where
- China
- Volunteers
- 138 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pulmonary Nodules
Multicenter Prospective Validation of AI Models for Malignancy Risk Prediction in Pulmonary Nodules
This multicenter prospective diagnostic accuracy study will compare the performance of three artificial intelligence (AI) models (MVCS, LungDoc, and a United Imaging AI model) for predicting the malignancy risk of pulmonary…
- Trial name
- NCT07727122
- Where
- 5 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Solitary Lung Nodule, Multiple Pulmonary Nodules
A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules
Some studies have shown that the model for judging and predicting the growth of sub-solid pulmonary nodules through big data and deep learning can detect nodule growth earlier.
- Trial name
- NCT06458673
- Where
- China
- Volunteers
- 1,184 people
- Sponsor
- Guangdong Provincial People's Hospital
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
Lung Cancer, Lung Nodule
SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier
The purpose of this study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses lung cancer.
- Trial name
- SPARC (NCT07460440)
- Testing
- Platelet RNA-based assay
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Utah
Lung Nodules, Bronchoscopy
AI-Driven Autonomous Registration in Robotic Bronchoscopy
This study aims to evaluate the feasibility and safety of an artificial intelligence (AI)-driven autonomous registration technology in robotic navigational bronchoscopy.
- Conditions
- Lung Nodules, Bronchoscopy, Localization Efficiency
- Trial name
- NCT07368829
- Testing
- AI-driven autonomous registration
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization
This study evaluates whether multiparametric chest magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), performed without any contrast material, can distinguish malignant from benign lung lesions that were…
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
- Trial name
- NCT07768046
- Testing
- Multiparametric chest MRI with diffusion-weighted imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Lung Cancer, Pulmonary Nodule
Exhaled Breath Electronic Nose for Multi-Disease Risk Prescreening
This prospective multicenter observational study will evaluate whether an electronic nose that analyzes patterns in exhaled breath can be developed as a noninvasive tool for early risk prescreening across several disease areas.
- Conditions
- Lung Cancer, Pulmonary Nodule, Chronic Respiratory Disease, Metabolic Disease
- Trial name
- BREATH-PAN (NCT07804017)
- Testing
- Electronic-Nose Breath Assessment
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Multiple Pulmonary Ground-Glass Nodules, Lung Neoplasms
Nebulized Inhalation of Recombinant Human p53 Adenovirus Injection for Treatment of Multiple Ground-Glass Lung Nodules: A Single-Arm Clinical Study
This study aims to evaluate the safety and efficacy of nebulized inhalation of Recombinant Human Ad-p53 Injection (Gendicine®) for the treatment of multiple ground-glass lung nodules.
- Conditions
- Multiple Pulmonary Ground-Glass Nodules, Lung Neoplasms, Precancerous Conditions
- Trial name
- NCT07150416
- Testing
- Recombinant Human Ad-p53 Injection
- Where
- China
- Volunteers
- 38 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Adenocarcinoma
Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
This is an open label, phase II study to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR…
- Trial name
- NCT05528458
- Testing
- Osimertinib 80Mg Tab
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Indeterminate Pulmonary Nodule
Nodify Lung Testing for Pulmonary Nodules
The STRATIFY Study is an observational study for adults age 40 or older who have a lung nodule that is not clearly benign or cancerous. The study will enroll up to 1,000 participants at about 10-12 U.S.
- Trial name
- STRATIFY (NCT07858552)
- Volunteers
- 1,000 people
- Sponsor
- Biodesix, Inc.
Lung Ground-glass Opacities, Active Surveillance
Surveillance for Multifocal GGNs
This study is a single-arm, multi-center, phase III trial conducted under the Eastern Cooperative Thoracic Oncoloy Project (ECTOP) with the identification number ECTOP-1021.
- Trial name
- NCT06097910
- Testing
- Watchful waiting
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Fudan University
Lung Cancer
Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs)
The goal of this observational study is to learn whether a urine-based test that measures volatile organic compounds (VOCs) can help detect lung cancer in people who have never smoked.
- Trial name
- NCT07871656
- Testing
- Biosensor Platform
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Thomas Jefferson University