Clinical trials: Pulmonary Vein Ablation
Persistent Atrial Fibrillation
CARTO-Finder Guided Ablation Versus Multiscale Entropy Guided Ablation in Persistent Atrial Fibrillation
This is a randomized control trial to compare the efficacy and safety of CARTO-Finder-guided ablation plus pulmonary vein isolation versus multiscale entropy (MSE)-guided pulmonary vein isolation in patients with persistent…
- Trial name
- NCT05454111
- Testing
- Multiscale entropy-guided ablation plus PVI, CARTO-Finder-guided ablation plus PVI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Evaluation of the Incidence of Cerebral Lesions Post Pulmonary Vein Ablation Catheter (PVAC)
The purpose of the study is to determine the rate of diffusion weighted (DW)-MRI cerebral lesions following a Pulmonary Vein Ablation Catheter (PVAC) ablation procedure performed using best practices, including optimized…
- Trial name
- ERACE (NCT01520532)
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 7 sites in Belgium, Canada and 3 more
- Volunteers
- 60 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Persistent Atrial Fibrillation
VEin of MArshall Ethanolization Vs Extended Pulmonary Vein PULSEd Field Ablation After Failed PVI for Persistent AF
The goal of this clinical trial is to compare two ablation techniques to treat patients with persistent atrial fibrillation (irregular and often very rapid heart rhythm).
- Trial name
- VEMAPULSE (NCT06383975)
- Testing
- Pulsed field ablation with posterior wall isolation, Radiofrequency ablation and vein of Marshall ethanolization
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Sebastien Knecht
Atrial Fibrillation
Pulmonary Veins Circular Ablation Catheter Evaluation for Atrial Fibrillation
The aim of this study is to compare two type of ablation catheters for pulmonary veins isolation (PVI) in subjects with atrial fibrillation. Currently, two technologies of irrigated ablation catheters are available for PVI.
- Trial name
- EVACIRC (NCT02107027)
- Testing
- nMARQ catheter, Navistar catheter
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Association de Recherche pour le Traitement des Arythmies Cardiaques
Atrial Fibrillation
PV Cryoablation Efficacy (COR ADVANCE Study)
The COR advance study is a non-randomized prospective single center study to assess the results of an electrophysiologically guided approach for PV cryoablation using the Arctic Front Advance ST® catheter together with the…
- Trial name
- COR-ADVANCE (NCT02588183)
- Testing
- ArticFont Advance ST Cryoenergy Balloon Catheter
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital San Carlos, Madrid
Atrial Flutter Typical
Prophylactic Pulmonary Vein Isolation During Atrial Flutter Ablation
Pulmonary vein isolation (PVI) via catheter ablation has been successfully employed for years to treat symptomatic atrial fibrillation (AF).
- Trial name
- PREVENT-AF II (NCT07649603)
- Testing
- Catheter ablation
- Volunteers
- 620 people
- Sponsor
- University of Rochester
Atrial Fibrillation
Trigger- vs. Substrate-Ablation for Paroxysmal Atrial Fibrillation
The purpose of this study is to compare two strategies of catheter-based treatment of paroxysmal atrial fibrillation: Pulmonary vein isolation either alone or combined with electrogram-guided substrate-ablation.
- Trial name
- NCT00196183
- Testing
- trigger-guided catheter-ablation, trigger+substrate-guided catheter ablation
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Atrial Fibrillation; Paroxysmal Atrial Fibrillation; Persistent Atrial Fibrillation
Pulsed Field Ablation of Atrial Fibrillation: CENTAURI Versus FARAPULSE
The aim of this study is to compare the efficacy of two commercially available pulsed field ablation (PFA) systems for catheter ablation of atrial fibrillation.
- Trial name
- NCT07902739
- Testing
- CENTAURI PEF system, FARAPULSE system
- Where
- Czechia
- Volunteers
- 325 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Atrial Fibrillation
Effect of the Autonomic Nervous System on the Outcomes of PULSEd Field Ablation to Treat Atrial Fibrillation
Pulmonary vein (PV) isolation is considered the therapeutic strategy of choice to maintain sinus rhythm (SR) in symptomatic patients with atrial fibrillation (AF). The most commonly used energy modality is radiofrequency (RF).
- Trial name
- EASy-PULSE AF (NCT06351553)
- Testing
- Pulmonary vein isolation exclusively with radiofrequency, Pulmonary vein isolation exclusively with pulsed field ablation, Combined pulmonary vein isolation
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospital General Universitario de Alicante
Atrial Fibrillation, Radiofrequency Ablation
Pulmonary Vein (PV) Isolation Versus Box Isolation for the Treatment of Atrial Fibrillation
Curative catheter ablation has been established as an effective therapeutic option for atrial fibrillation (AF) that is resistant to pharmacologic rhythm or rate control.
- Trial name
- NCT01091597
- Testing
- usual PV ablation, Box isolation of pulmonary veins
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Paroxysmal Atrial Fibrillation
A Single Arm Pilot Study of Pulsed Field Ablation in the Treatment of Paroxysmal Atrial Fibrillation
The objective of this pilot study is to confirm that endocardial ablation using the FARAPULSE Ablation System Plus with commercial design devices is both safe and effective for treating drug-resistant paroxysmal atrial…
- Trial name
- FARA-Free (NCT04474054)
- Testing
- Catheter ablation to treat paroxysmal atrial fibrillation
- Where
- Croatia
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation
There is a need to compare the efficacy of PVI versus PVI plus catheter ablation, which includes ablation of complex fractionated atrial electrograms (CFAE) and linear lesions in the same procedure.
- Trial name
- NCT03115554
- Testing
- PVI Plus Catheter Ablation, PVI Alone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation
First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study)
The purpose of this study is to determine whether catheter-based pulmonary vein isolation is superior to antiarrhythmic drugs as first line therapy in patients with symptomatic paroxysmal recurrent atrial fibrillation not…
- Trial name
- RAAFT (NCT00392054)
- Testing
- Pulmonary Vein Isolation performed by Catheter Ablation, Conventional Antiarrhythmic Drug Therapy
- Where
- 16 sites in United States, Canada and 3 more
- Volunteers
- 127 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation
Predictive Factors for Successful Outcome After Pulmonary Veins Ablation to Treat Paroxysmal Atrial Fibrillation
Atrial fibrillation is the most common serious abnormal heart rhythm affecting about 2% to 3% of the population, being associated with a 1.5- to 1.9-fold higher risk of death.
- Trial name
- NCT02614521
- Testing
- pulmonary veins ablation's successful outcome
- Where
- Greece
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Paroxysmal Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
Pulsed Field Ablation of SVC and PV in Paroxysmal Atrial Fibrillation (PASPA Study)
The PASPA study is a multicenter, randomized trial comparing Pulmonary Vein Isolation (PVI) alone versus PVI plus Superior Vena Cava Isolation (SVCI) using Pulsed Field Ablation (PFA) in patients with paroxysmal atrial…
- Trial name
- PASPA (NCT07191626)
- Testing
- PFA - PV + SVCI, PFA - PVI only
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation (AF), Persistant Atrial Fibrillation
A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation
The purpose of this study is to establish the safety of the pulsed field ablation (PFA) therapy of Pulmonary Veins and Electrographic Flow (EGF) identified extra-PV sources of atrial fibrillation (PVI + EGF ablation of sources)…
- Trial name
- OPTIMIZE (NCT07187115)
- Testing
- FARAPOINT Pulsed Field Ablation System, OptiMap System (non-ablative), FARAPULSE Pulsed Field Ablation (PFA) System and Opal HDx Mapping System
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 699 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation Recurrent
The Impact of Autonomic Function on Atrial Fibrillation Recurrence After Pulmonary Vein Ablation
This is a prospective and observational study. The investigator speculated that the use of DC in patients with paroxysmal AF can serve as a predictor for early and late AF recurrence following CPVI.
- Trial name
- NCT06202209
- Testing
- Circumferential Pulmonary Vein Isolation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Fibrillation, Atrial, Atrial Cardiomyopathy
Atrial Fibrillation (AF) Ablation to Prevent Disease Progression of AF-induced Atrial Cardiomyopathy in Women and Men
The goal of clinical trial is to compare AF ablation to pharmacological rhythm management (being rate or rhythm control) in AF patients with signs of atrial cardiomyopathy (as defined by left atrial volume index >34 ml/m2) The…
- Trial name
- RACE X (NCT06200311)
- Testing
- Pulmonary vein isolation, Pharmacological rhythm management
- Where
- Netherlands
- Volunteers
- 604 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation (AF)
Redo-Pulmonary Vein Isolation With Versus Without Posterior Wall Ablation - The REDO-PIFPAF-PFA Study
The study will compare two ablation strategies in patients with paroxysmal or persistent atrial fibrillation undergoing repeat ablation using pulsed-field ablation: redo pulmonary vein isolation only versus redo pulmonary vein…
- Trial name
- NCT07745543
- Testing
- Pulmonary vein isolation with posterior wall ablation, Pulmonary vein isolation without posterior wall ablation
- Where
- 5 sites in Switzerland
- Volunteers
- 270 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation, Heart Failure
Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation With Heart Failure
The combination of atrial fibrillation (AF) and heart failure (HF) is common and implies a poor prognosis. Pulmonary vein isolation is an established method for the treatment of symptomatic AF in patients with normal heart…
- Conditions
- Atrial Fibrillation, Heart Failure, Cryoballon Ablation
- Trial name
- POLAR-HF (NCT04461691)
- Testing
- Cryoballoon Pulmonary Vein Isolation
- Where
- Germany
- Volunteers
- 1,420 people
- Sponsor
- St. Josefs-Hospital Wiesbaden GmbH