Clinical trials: Pulp Necrosis, Apical Periodontitis
Pulp Necrosis, Apical Periodontitis
Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
This randomized controlled clinical trial evaluates the effect of conventional metronidazole and nano-formulated metronidazole as root canal irrigants, with and without ultrasonic activation, in patients with necrotic…
- Trial name
- NCT07897591
- Testing
- Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Apical Periodontitis, Pain
One vs Two Visits Root Canal Treatments in Infected Teeth
The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment.
- Conditions
- Apical Periodontitis, Pain, Tooth Loss, Dental Pulp Necrosis
- Trial name
- NCT04605445
- Testing
- 1 visit root canal treatment (endodontics), 2 visits root canal treatment (endodontics)
- Where
- 7 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Malmö University
Periapical Lesion, Apical Periodontitis
Effect of Apical Patency on Periapical Lesion Healing
This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth.
- Conditions
- Periapical Lesion, Apical Periodontitis, Dental Pulp Necroses, Mouth Diseases
- Trial name
- NCT07867314
- Testing
- Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Recep Tayyip Erdogan University
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Symptomatic Apical Periodontitis, Pulp Necrosis
Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis
This randomized, participant- and outcome assessor-blinded, 2 × 2 factorial clinical trial evaluated the effects of intracanal cryotherapy and two intracanal medicaments-calcium hydroxide and metformin-on postoperative…
- Trial name
- NCT07437612
- Testing
- Placement of calcium hydroxide as an intracanal medicament, Placement of metformin as an intracanal medicament, Application of calcium hydroxide as an intracanal medicament together with intracanal cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Celalettin Topbaş
Pulp Necrosis, Apical Periodontitis
The Effect of Different Intra-canal Medications on Postoperative Pain
The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients…
- Trial name
- NCT07603934
- Testing
- ibuprofen, Nitrofurantoin, Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Periodontitis, Chronic Periapical Periodontitis
Evaluation of Bone Healing After Obturation With Dia-Root Bio Sealer (Calcium Silicate-based Sealer CSBS) Using Three Obturation Techniques
The study aims to evaluate the efficiency of using a Calcium silicate-based sealer (CSBS) with different obturation techniques in treating root canals with apical periodontitis in single visit. Evaluating: 1.
- Conditions
- Periapical Periodontitis, Chronic Periapical Periodontitis, Periapical Abscess, Pulp Necrosis, Apical Periodontitis
- Trial name
- CSBS (NCT07684014)
- Testing
- Dia-Root Bio Sealer, Single cone (SC) Obturation technique, Warm Vertical compaction (WVC) technique
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Ain Shams University
Dental Pulp Necrosis, Apical Periodontitis
Antimicrobial Efficacy of NaOCl and PDT in Primary Root Canal Treatment
This clinical study will compare different root canal disinfection methods used during primary root canal treatment. Root canal infection is mainly caused by bacteria inside the root canal system.
- Trial name
- PDT-NaOCl (NCT07666932)
- Testing
- Sodium Hypochlorite Irrigation, Sodium Hypochlorite Irrigation Plus Photodynamic Therapy, Photodynamic Therapy Adjunct Evaluation
- Where
- Jordan
- Volunteers
- 64 people
- Sponsor
- Bayan Alqrenawi
Pulp Necroses, Apical Periodontitis
"Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"
The aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial.
- Conditions
- Pulp Necroses, Apical Periodontitis, Pulp Disease, Dental
- Trial name
- NCT06129643
- Testing
- Conventional group, Dual laser group, Combined group
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Necrotic Pulp, Asymptomatic Apical Periodontitis
Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques
Brief Summary Postoperative pain is a common complication following root canal treatment, particularly in necrotic teeth with asymptomatic apical periodontitis.
- Trial name
- NCT07310212
- Testing
- Warm Vertical Condensation (WVO), Cold Lateral Condensation (CLC)
- Where
- Jordan
- Volunteers
- 80 people
- Sponsor
- University of Jordan
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pulp and Periapical Tissue Disease, Patients With Pulp Necrosis and Apical Periodontitis
Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis
The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic…
- Trial name
- NCT06713174
- Testing
- Assessment of Interleukin 8 and 10 Level Changes Before and During Root Canal Treatment for Necrotic Pulp with Apical Periodontitis
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Pulp Necrosis, Apical Periodontitis
CGF-Enhanced Autologous Pulp Transplantation in Mature Necrotic Teeth
This pilot clinical study evaluated the clinical, radiographic, and functional outcomes of autologous pulp transplantation combined with concentrated growth factor (CGF) in mature permanent teeth with pulp necrosis and periapical…
- Trial name
- CGF-PULP (NCT07314866)
- Testing
- Autologous Pulp Transplantation With Concentrated Growth Factor
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Irreversible Pulpitis, Apical Periodontitis
Bite Force Measurements
ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
- Trial name
- NCT06843525
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Rutgers, The State University of New Jersey
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Pulp Necrosis, Apical Periodontitis
Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods
This randomized clinical trial aims to evaluate the antibacterial efficacy and treatment outcomes of three different final irrigation protocols during root canal therapy: 2.5% sodium hypochlorite alone, sodium hypochlorite with…
- Conditions
- Pulp Necrosis, Apical Periodontitis, Endodontic Treatment
- Trial name
- ENDOABG (NCT06959602)
- Testing
- Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- National and Kapodistrian University of Athens
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Necrotic Pulp, Regenerative Endodontic Procedures
Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial
This study investigates a biological approach that allows infected and necrotic teeth to heal themselves instead of being treated with traditional root canal therapy.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Mature Teeth, Apical Periodontitis
- Trial name
- NCT06886438
- Testing
- RVS, L-PRF, i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi