Clinical trials: Puncture
Informed Consent, Health Literacy, Risk, Spinal Puncture, Neurosurgery
Communicating Risks: Consent for Lumbar Puncture
The goal of this randomized control trial is to compare the effect of visual aids on the recall of probabilistic risks in healthy participants.
- Trial name
- NCT05717465
- Testing
- Anatomy diagrams, Standard informed consent
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Multiple Sclerosis
DECISIve - DiagnosE Using the Central veIn SIgn v1.0
DECISIve - DiagnosE using the Central veIn SIgn. A prospective diagnostic superiority study comparing T2* MRI and lumbar puncture in patients presenting with possible Multiple Sclerosis
- Trial name
- DECISiVE (NCT05533905)
- Testing
- Lumbar puncture, MRI
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Breast Cancer
Can Methylprednisoloneacetate Prevent Seroma After Mastectomy for Primary Breast Cancer
A randomised double-blinded study, in which the patients either get methylprednisoloneacetate or saline solution in the mastectomy cavity to evaluate the efficacy of methylprednisoloneacetate in preventing seroma in patients…
- Trial name
- NCT01380912
- Testing
- methylprednisoloneacetate
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital at Herlev
Leukemia, Lymphoid Malignancies
Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System
The goal of this clinical research study is to learn about the safety and effectiveness of rituximab given by spinal tap in patients with lymphoid malignancies involving the central nervous system.
- Conditions
- Leukemia, Lymphoid Malignancies, Metastatic Malignant Neoplasm to the Leptomeninges
- Trial name
- NCT01596127
- Testing
- Intrathecal Rituximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Evaluation of the Radiofrequency Transseptal Puncture System, Atrial Septum Puncture
Prospective, Multicenter, Randomized Controlled, Non-inferior Clinical Study to Evaluate the Safety and Efficacy of Radiofrequency Transseptal Puncture System in Atrial Septul
To evaluate the safety and efficacy of radiofrequency transseptal puncture system and its auxiliary radiofrequency puncture device in atrial septum.
- Trial name
- NCT06990230
- Testing
- Radiofrequency Transseptal Puncture System and Auxiliary Device
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Post-Dural Puncture Headache
EPiMAP Obstetrics: European Practices in the Management of Accidental Dural Puncture in Obstetrics
The aims of EPiMAP Obstetrics are: to identify risk factors for failure of epidural blood patch in the obstetric population for management of post dural puncture headache.
- Trial name
- EPiMAP (NCT02362828)
- Where
- Sweden
- Volunteers
- 1,110 people
- Sponsor
- European Society of Anaesthesiology
Indication of Blood Gas Analysis by Radial Artery Blood Sampling
Local Anesthesia Before Arterial Puncture for Blood Gas Analysis
The aim of the study is to evaluate the interest of Local Anesthesia (lidocaïne/prilocaïne versus placebo)before arterial puncture for Blood Gas Analysis.
- Trial name
- GAEL (NCT01964248)
- Testing
- lidocaïne/prilocaïne 5%
- Where
- France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Brest
Traumatic Brain Injury (TBI)
Functional Recovery Effect of Bloodletting Puncture at Jing-well Points on Acute Brain Injury Patients
Traumatic brain injury (Traumatic brain injury, TBI) can be derived from various forms of injury, including blunt trauma, penetrating or acceleration/deceleration force caused by head injury.There are some study data show that…
- Trial name
- NCT04930146
- Testing
- acupuncture and bloodletting
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Radial Artery Catheterization, Paediatric
Innovative Probe With Laser on Radial Artery Puncture and Catheterisation in Paediatric
During prolonged major surgical procedures in paediatric, significant fluctuations in vital signs occur. To ensure real-time, precise monitoring of haemodynamic parameters such as blood pressure and heart rate for maintaining…
- Conditions
- Radial Artery Catheterization, Paediatric, Ultrasound Guided
- Trial name
- NCT07454005
- Testing
- T-shaped probe ultrasound guidance, Out-of-plane ultrasound guidance
- Where
- China
- Volunteers
- 408 people
- Sponsor
- The First Hospital of Jilin University
Peripheral Arterial Disease, Arterial Puncture
The Safety and Efficacy of the Suture-Mediated Closure System
This was a prospective, multicenter, randomized, controlled, non-inferiority clinical study with the primary objective of validating the safety and efficacy of the Suture-Mediated Closure System for percutaneous closure of the…
- Trial name
- NCT05841836
- Testing
- the Suture-Mediated Closure System, Perclose ProGlide Suture-Mediated Closure System
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Healthy Volunteers
CYP2C9 Activity Evaluated With a Simple Finger Prick
The cytochrome P450 enzymes (CYP) are the major drug-metabolizing enzyme system in humans. A great inter- individual variability affects the activity of these enzymes, and consequently the plasma drug concentrations resulting in…
- Trial name
- NCT01026714
- Testing
- flurbiprofen, flurbiprofen, rifampicin, flurbiprofen + fluconazole
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Immediate Type Hypersensitivity
Comparison of Skin Prick Testing Results of Local and Imported Pollen Allergen Extracts and Specific IgE
Pollen allergen extracts are prepared locally and checked for efficacy by comparison to imported allergens and specific IgE.
- Trial name
- NCT02764827
- Testing
- Pollen sensitization
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Two Different Techniques to Perform Epidural Using Ultrasound
Accuro and the Use of Real Time Ultra Sound With Acoustic Puncture Assisted Device to Confirm Epidural Space End Point
Aim of the work: To compare the use of the Accuro ultrasound and a real time ultrasound guided epidural combined with the acoustic puncture assisted device to perform the epidural anesthesia Secondary aim is to compare the…
- Trial name
- NCT04204070
- Testing
- Accuro, APAD
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Catheters, Catheterization, Peripheral
Prospective, Randomized Controlled Comparison of TERUMO SurFlash Plus Versus BD Insyte Autoguard in an Urban ED
A randomized prospective comparison of two FDA approved intravenous catheters in the emergency department setting. The Terumo SurFlash Plus offers novel technologies that promise to increase intravenous access success rates and…
- Trial name
- NCT02769442
- Testing
- Terumo SurFlash Plus catheter, BD Insyte Autoguard catheter
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Maryland, Baltimore
Paroxysmal Atrial Fibrillation
Comparison of Single Groin and Single Trans-septal Puncture and Conventional Bilateral Groin Puncture and Double Trans-septal Puncture in Catheter Ablation for Atrial Fibrillation
The purpose of this study is to compare single groin puncture and bilateral groin puncture during AF ablation procedure. The investigators will compare 1) the degree of patients' discomfort during hemostasis by questionaire, 2)…
- Trial name
- NCT02438176
- Testing
- single trans-septal puncture, conventional bilateral groin puncture
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Yonsei University
Biomarker
Exploring the Potential of Finger Prick Blood for Assessment of BIOmarkers for LOw Grade Inflammation and CVD Risk
There are currently no minimally invasive techniques for the measurement of lipopolysaccharide (LPS) and Apo-B48 that can be used in samples collected in field settings.
- Trial name
- BIOLOGIC (NCT04996589)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Wageningen University and Research
Multiple Sclerosis
DiagnosE Using the Central veIn SIgn
There is currently no agreement on the best way to diagnose Multiple Sclerosis (MS). Frequently, people suspected of having MS have a standard MRI scan and undergo a 'lumbar puncture' (a thin needle is inserted between the bones…
- Trial name
- DECISIve (NCT04024969)
- Testing
- T2* MRI, Lumbar puncture to test for presence of unmatched oligoclonal bands
- Where
- 4 sites in United Kingdom
- Volunteers
- 115 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Vascular Access Complication
AGIR Study: Angio-Seal in Interventional Radiology
Clinical study in patients undergoing any intervention requiring vascular access to the femoral artery. The study compares Angio-Seal™ vs. Manual Compression with regard to control the vascular access.
- Trial name
- AGIR (NCT01911403)
- Testing
- Manual compression, Angio-Seal
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 123 people
- Sponsor
- Abbott Medical Devices
Lumbar Puncture
SHAPE for ICP Assessment
The Subharmonic Aided Pressure Estimation (SHAPE) technique is a noninvasive ultrasound-based imaging technique that can estimate ambient pressure using subharmonic emissions from ultrasound contrast agents.
- Trial name
- NCT06571786
- Testing
- Perflutren lipid microsphere
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Subarachnoid Haemorrhage (SAH)
Serum GFAP and UCHL1: Evaluation of Their Predictive Value for SAH
To verify the analytical performance of GFAP and UCH-L1 biomarkers marketed by Abbott Diagnostics and to assess diagnostic accuracy of these biomarkers in predicting subarachnoid haemorrhage
- Trial name
- SAH (NCT06581757)
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust