Clinical trials: Pupil
Visual Impairment, Ocular Illness
Pupillometry and Locus Coeruleus Activation (PuLCA)
This project will apply non-invasive, trans-cutaneous vagal nerve stimulation using various stimulation parameters to young, healthy adults to find the optimal set of parameters to elicit pupil response.
- Trial name
- PuLCA (NCT04579653)
- Testing
- transcutaneous electrical nerve stimulation devices
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Sexual Harassment
Evaluation of Virtual Course to Increase Knowledge in Sexual Harassment,Prevention and Sanction Policies of a University
Sexual harassment is the behavior of sexual or sexist connotation unwanted by the affected person. Despite being considered as gender-based violence, victims of sexual harassment can be of both sexes.
- Trial name
- NCT04021849
- Testing
- Face-to-face Class, Asynchronous Virtual Class
- Where
- Peru
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Autism Spectrum Disorder
Effectiveness of the Autism Pupil Screen (APS) Detect Pupillometer for Identifying Autism Spectrum Disorder (ASD) in Routine Healthcare
Autism spectrum disorder (ASD) is a developmental condition that can affect communication, social interaction, and behavior. Identifying ASD early helps children and families access support services sooner.
- Trial name
- APS001 (NCT07903675)
- Testing
- Autism Pupil Screen (APS) Detect PLR Assessment #1, Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT/R-F), Social Responsiveness Scale, Second Edition (SRS-2)
- Where
- 4 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Schweitzer Engineering Laboratories
Pupillary Dilation Effect During Cycloplegic Refraction
Comparing Efficacy and Safety of CTO0303 in Pediatric Subjects
This is a prospective randomized study compared with active control arm.
- Trial name
- NCT06609525
- Testing
- CTO0303-A, CTO0303-B, CTO0303-C
- Where
- South Korea
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Opioid Toxicity, Pupillary Miosis
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60.
- Conditions
- Opioid Toxicity, Pupillary Miosis, Respiratory Depression
- Trial name
- NCT05391555
- Testing
- Remifentanil Hydrochloride, Pupillometry measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Paresis
Pupil-Indexed Noninvasive Neuromodulation
Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning.
- Trial name
- NCT06282406
- Testing
- Transcutaneous Electrical Stimulation
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Circadian Rhythm, Pupillometry
Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep
The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.
- Conditions
- Circadian Rhythm, Pupillometry, Sleep
- Trial name
- SCOPE (NCT07753889)
- Testing
- Ocular light exposure from portable light box
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elizabeth B Klerman MD PhD
Normal Non-fluency, Cataract
Comparative Study of the Optical Biometer for Measurements of the Eye
The primary purpose of this comparative clinical study is to collect clinical data to demonstrate the equivalence of the investigational device to the predicate device for measurements of the eye.
- Conditions
- Normal Non-fluency, Cataract, Aphakic Eye, Eyes With Corneal Abnormality
- Trial name
- NCT01729962
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Surgery
Topical 0.4% Ketorolac and Vitreoretinal Surgery
To determine whether use of topical 0.4% ketorolac has any effect on pupil size during vitreoretinal surgery.
- Trial name
- NCT00576329
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Emory University
Chronic Pain Due to Injury
Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)
The goal of this study is to test the effects of oxytocin on heart rate variability and pupil diameter, both of which have subtle effects on the activity rate of the autonomic nervous system.
- Trial name
- NCT04105998
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Small Pupil, Cataract
Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases
To evaluate the intraoperative stability, safety and overall efficacy of the Canabrava Ring (AJL - SPAIN) when used to expand pupils with less diameter than 5 mm and pupils with sphincter synechiae.
- Trial name
- NCT03206983
- Testing
- Cana's Ring
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Santa Casa de Misericórdia de Belo Horizonte
no Condition, Electroencephalography
Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation
This study investigates the capacity of non-invasive vagus nerve stimulation, applied at the ear, to alter to measures of locus coeruleus output pupil diameter and EEG alpha power.
- Conditions
- no Condition, Electroencephalography, Pupil Diameter
- Trial name
- NCT04455295
- Testing
- Transdermal Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Arkansas Tech University
Eye Cyclorotation Degree, Pupil Shift
Evaluation of Position-induced Cyclorotation Between Wavefront Measurement and Refractive Surgery by the Iris Registration Method
Cyclorotation of eyes may be affected by motion and orientation of the head and body. An automated alignment method with the technique of iris recognition was used to assess the amount and orientation of position-induced…
- Trial name
- NCT00943163
- Where
- Taiwan
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Head Injury, Traumatic Brain Injury (TBI)
The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
After a head injury, many people find that exposure to light causes them increased discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue light, this study will investigate whether this phenomenon…
- Conditions
- Head Injury, Traumatic Brain Injury (TBI), Photosensitivity, Photophobia
- Trial name
- HIPP (NCT01942564)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Career Decision-making Difficulties, Worry
REBT Intervention Program for Career Decision-making Difficulties in High School Pupils
Career decision-making difficulties are frequent problems for adolescents. Regular intervention or prevention programs mainly provide information for the students about themselves, about the world of work, about their interests…
- Conditions
- Career Decision-making Difficulties, Worry, Psychological Distress
- Trial name
- NCT03807895
- Testing
- REBT Career Intervention, Regular Career Intervention
- Where
- Romania
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Cataract, Myopia
Evaluating the Effect of Laser Vision Surgery, Phakic Intraocular Lens Implantation, Cataract Surgery, and Pupil Dilation on the Iris Recognition Scanner Function of Smartphone
This study included patients who visit for refractive surgery (photorefractive keratectomy, photorefractive keratectomy with with corneal collagen cross linking, laser in situ keratomileusis, small incision lenticule extraction)…
- Conditions
- Cataract, Myopia, Myopic Astigmatism
- Trial name
- NCT02939001
- Testing
- iris recognition scanner
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Obesity
Evaluation of California's SB 19 Pupil Nutrition Act
Four California school districts will be randomized to early implementation of California's SB 19 Pupil Nutrition Act or to business as usual.
- Trial name
- NCT00067847
- Testing
- State-directed nutrition policy change
- Where
- United States
- Volunteers
- 5,020 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Intraocular Pressure
The Effect of Brimonidine
This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or after dilating the pupils will help to control the changes in intraocular pressure often seen when using dilating drops.
- Trial name
- NCT03959176
- Testing
- Brimonidine, Tropicamide, Phenylephrine Ophthalmic Product
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Myopia
The Effects of Low Concentration Atropine on Pupil Size and Accommodation
The purpose of this study is to determine whether less frequent dosing of atropine drops may be as effective as daily dosing for the treatment of progressive myopia.
- Trial name
- NCT02870478
- Testing
- Atropine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Retinopathy of Prematurity
A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity.
A prospective, randomized controlled study was conducted from August, 2022 to March, 2023 in the neonatal intensive care unit in Queen Mary Hospital, Hong Kong.
- Trial name
- NCT06288321
- Testing
- Microdrop Mydrin-P, Standard Mydrin-P
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong