Clinical trials: Pupil
Cataract, Myopia
Evaluating the Effect of Laser Vision Surgery, Phakic Intraocular Lens Implantation, Cataract Surgery, and Pupil Dilation on the Iris Recognition Scanner Function of Smartphone
This study included patients who visit for refractive surgery (photorefractive keratectomy, photorefractive keratectomy with with corneal collagen cross linking, laser in situ keratomileusis, small incision lenticule extraction)…
- Conditions
- Cataract, Myopia, Myopic Astigmatism
- Trial name
- NCT02939001
- Testing
- iris recognition scanner
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Loneliness
INcreasing Adolescent Social and Community SupporT - Pilot
Background: Social prescribing is a mechanism of connecting patients with non-medical forms of support within the community and has been shown to improve loneliness. Yet uptake from young people has been lower than for adults.
- Trial name
- INACT (NCT06656663)
- Testing
- Social Prescribing, Signposting
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- University College, London
Optic Neuritis
TLR-9 Antagonism in Steroid Resistant Optic Neuritis
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients.
- Trial name
- NCT01424735
- Testing
- Mycobacterium w.(Mw)-freeze dried extract 0.5ml
- Where
- India
- Volunteers
- 8 people
- Sponsor
- Sudhalkar Eye Hospital
Myopia
The Effects of Low Concentration Atropine on Pupil Size and Accommodation
The purpose of this study is to determine whether less frequent dosing of atropine drops may be as effective as daily dosing for the treatment of progressive myopia.
- Trial name
- NCT02870478
- Testing
- Atropine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Anxiety, Depression
Mindfulness as a Method of Improving the Well-being, Quality of Life and Health of Primary School Pupils
This study evaluates the short and long-term effect of 5-10 minutes daily mindfulness and compassion training in school among children aged between 6-16 years old.
- Trial name
- NCT03327714
- Testing
- Mindfulness and compassion
- Where
- Sweden
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Lund University
Stroke, Healthy Adult
tVNS Responsiveness Testing With Pupil Size
The goal of this study is to learn about the acute pupil response to transcutaneous vagus nerve stimulation (tVNS) in stroke survivors and healthy adults.
- Trial name
- NCT06335199
- Testing
- Unilateral Left tVNS stimulation, Bilateral tVNS stimulation, Unilateral Right tVNS stimulation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Measurement of Pupil Diameter
Comparison of Two Different Pupillometer
With the development of refractive surgery, the size of scotopic pupil has been widely concerned by clinicians. Historically, the measurement of pupil size included the use of a pupil ruler, which is known for its drawback of…
- Trial name
- NCT05717244
- Testing
- 2WIN-S, OPD
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- He Eye Hospital
Mydriasis, Dilation
Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3)
The objectives of this study are: To evaluate the efficacy of Nyxol to expedite the reversal of pharmacologically-induced mydriasis across multiple mydriatic agents with an emphasis on phenylephrine To evaluate the efficacy of…
- Trial name
- MIRA-3 (NCT05134974)
- Testing
- Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle
- Where
- 15 sites in United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Cataract
A Dynamic Study of Pupil Diameter After Artificial Lens Implantation in Patients With High Myopia
Age-related cataract remains the leading cause of blindness in developing countries. And, with the aging of the population in these countries, the number of cataract patients will continue to grow.
- Trial name
- NCT06505434
- Testing
- Cataract surgery
- Volunteers
- 60 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Horner's Syndrome, Stroke
Pupillometry in Horner's Syndrome
Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the…
- Conditions
- Horner's Syndrome, Stroke, Dissection Carotid Artery
- Trial name
- NCT02978079
- Testing
- Automated pupillometry
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- University of Zurich
Mydriasis
Study of the Safety, Efficacy and PK of EYN-1601 in Dilation of the Pupil
This is a Phase 2 study to investigate the safety, efficacy and pharmacokinetics of EYN-1601 for dilation of the pupil. A single microdose of EYN-1601 will be compared to single doses of commercially available phenylephrine…
- Trial name
- NCT02946125
- Testing
- MDD-administered EYN-1601, Phenylephrine 2.5% Eyedrop, Phenylephrine 10% Eyedrop
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Pupil Diameter, Pupil Contraction Rate
The Guiding Significance of Pupil Monitoring in the Perioperative Period
The pupil diameter is affected by both sympathetic and parasympathetic nerves, and its latency and response amplitude mainly reflect the functional status of the parasympathetic nerve.
- Conditions
- Pupil Diameter, Pupil Contraction Rate, Pupil Light Reflection
- Trial name
- NCT04820374
- Testing
- pupil's light and pupil diameter
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Yangzhou University
Myopia Progressing
Dynamic Pupil Variations and the Efficacy of Peripheral Defocus Spectacle Lenses in Slowing Myopia Progression
to evaluate the correlation between dynamic pupil variations and the efficacy of spectacle lenses in myopia progression control
- Trial name
- NCT07808047
- Testing
- perifheral defocus spectacle lenses, peripheral defocus spectacle lens
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Pain, Osteoarthritis
Reliability of Pupil Response to Acute Pain
The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced.
- Trial name
- NCT02628314
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Cataract
Comparative Study on Changes in Anterior Chamber Cytokines, Oxidative Stress, and Pupil Size After LenSx and Z8 Femtosecond Lasers
Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency…
- Trial name
- NCT06649799
- Testing
- LenSx, Z8
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Retinopathy of Prematurity
A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity.
A prospective, randomized controlled study was conducted from August, 2022 to March, 2023 in the neonatal intensive care unit in Queen Mary Hospital, Hong Kong.
- Trial name
- NCT06288321
- Testing
- Microdrop Mydrin-P, Standard Mydrin-P
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Myopia
Side Effects of Atropine (SEA) Study
This study will perform several objective and subjective measurements of the eye and vision before and after a week of using 0.01% concentration atropine drops.
- Trial name
- SEA (NCT03593044)
- Testing
- 0.01% concentration atropine drops
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Jeffrey J. Walline, OD PhD
Benign Prostatic Hyperplasia, Silodosin
Pupil Size and Choroidal Thickness Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients
Benign prostatic hyperplasia (BPH) is a common disease in men and is treated with alpha-blockers, particularly tamsulosin and silodosin.
- Conditions
- Benign Prostatic Hyperplasia, Silodosin, Tamsulosin, Choroid
- Trial name
- NCT07743060
- Testing
- tamsulosin 0.4mg, Silodosin 8 mg
- Volunteers
- 40 people
- Sponsor
- Mohsen Pourazizi
Diabetes (DM), Retinopathy, Diabetic
Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients
Pupil dilation is required for many eye conditions. Diabetic patients may need more dilating eye drops to have pupil size large enough for eye exams.
- Conditions
- Diabetes (DM), Retinopathy, Diabetic, Pupil Dilation
- Trial name
- NCT07495670
- Testing
- 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Burapha University
Pupil Dilation Prior to Cataract Surgery In-patient, Pupil Dilation Prior to Cataract Surgery Out-patient
Preoperative Cataract Pupillary Dilation: Inpatient At The Ambulatory Surgery Center vs Outpatient Dilation Prior To Arrival At The Ambulatory Surgery Center
This study was done to compare efficacy, safety and efficiencies of various methods of pupil dilation prior to cataract surgery.
- Trial name
- NCT01169688
- Testing
- Pupil dilation with phenylephrine 10% vs cyclopentolate 2%
- Volunteers
- 50 people
- Sponsor
- Northwest Kansas Surgery Center