Clinical trials: Pupil
Relative Afferent Pupil Defect (RAPD)
Measuring Relative Afferent Pupillary Defect
The goal of this prospective reliability study is to test the effectiveness of a commercially available, off-the-shelf virtual reality head-mounted display (VR HMD) and machine learning (ML) algorithms in detecting Relative…
- Trial name
- RAPD (NCT05799066)
- Testing
- Swinging Light test, Virtual Reality Head-Mounted Display (VR HMD)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cataract Surgery
Efficacy Mydrane ® for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma.
The aim of this study is to compare Mydrane ®, mydriatic eye drops and Mydriasert ® in terms of pupil site stability, surgical time, visual field and anterior chamber configuration modifications among primary open angle glaucoma…
- Trial name
- MIGA (NCT05925894)
- Testing
- Efficacy of a Standardized Intracameral Combination of Mydriatics and Anesthetic (Mydrane ®) for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cataract
Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery
The purpose of this study is to study the safety and efficacy of intracameral adrenaline for pupil dilation without topical mydriatics in refractive cataract surgery.
- Trial name
- NCT01264653
- Testing
- adrenalin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Brain Injuries, Traumatic
Prognostic Value of Pediatric GCS-Pupil Score in Pediatric Patients With Traumatic Brain Injury
There are studies reporting that the survival rate in pediatric patients with abnormal pupillary response is 23% and that pupillary response is effective on mortality and patient outcomes.
- Trial name
- NCT05419739
- Testing
- Glasgow coma scale
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Uludag University
Chronic Pain, Impaired Pupillary Reflex
Pupil Response in Patients on Opioids.
Evaluation of pupillary reflex in patients on high-dose opioids. Clinical assessment of pain intensity, sedation score, and other side effects of opioids.
- Conditions
- Chronic Pain, Impaired Pupillary Reflex, Opioid-Related Disorders
- Trial name
- Pupillometry (NCT02247024)
- Where
- 2 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Oslo University Hospital
Pupil, Analgesics
Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
The relationship between the target effect site concentration of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus in cardiac surgery during extra corporeal circulation will be…
- Conditions
- Pupil, Analgesics, Opioid Use, Dose-Response Relationship, Drug
- Trial name
- DOLOCEC (NCT03568396)
- Testing
- Pupillometer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Mydriasis
Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation
This study evaluated pupil dilation after administration of fixed combination tropicamide-phenylephrine (TR/PE) vs. phenylephrine (PE) alone and tropicamide (TR) alone. Participants attended 3 visits.
- Trial name
- MIST-1 (NCT03751631)
- Testing
- Tropicamide 1%-Phenylephrine 2.5% ophthalmic solution (TR/PE), Tropicamide 1% ophthalmic solution (TR), Phenylephrine 2.5% ophthalmic solution (PE)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Glaucoma
Is the RAPDx Pupillograph Able to Distinguish Between Glaucoma Subjects and Healthy Subjects?
The Konan RAPDx (Konan Medical USA, Irvine, CA) is a newly patented pupillography device.The aims of this study are to assess the ability of the RAPDx to distinguish between healthy subjects and patients with confirmed glaucoma…
- Trial name
- NCT02526693
- Testing
- Pupillometer
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Circadian Rhythm, Pupillometry
Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep
The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.
- Conditions
- Circadian Rhythm, Pupillometry, Sleep
- Trial name
- SCOPE (NCT07753889)
- Testing
- Ocular light exposure from portable light box
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elizabeth B Klerman MD PhD
Anisocoria
Wearing-Off Period of Pharmacological Dilation and Anisocoria
Students at the School of Medicine Greenville will be asked to participate in this study. The aim of this study is to better understand when medical imaging is needed for patients with anisocoria (unequal pupil size).
- Trial name
- NCT05238233
- Testing
- Tropicamide, 1% Pilocarpine, Proparacaine Hydrochloride
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Corneal Endothelial Cell Loss, Mydriasis
Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco
Study evaluates safety of intracameral injection of Fydrane (tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%) on corneal endothelium, and efficiency in maintaining pupillary dilatation during phacoemulsification surgery.
- Conditions
- Corneal Endothelial Cell Loss, Mydriasis, Cataract
- Trial name
- NCT04396301
- Testing
- Fydrane®: (Manufacturer DELPHARM TOURS, FRANCE).
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Artifical Intelligence, Cataract
Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye
This is a multi-center, cross-sectional study evaluating a smartphone-based artificial intelligence (AI) system for anterior segment eye disease screening.
- Conditions
- Artifical Intelligence, Cataract, Pterygium, Keratopathy
- Trial name
- LENS (NCT07634913)
- Testing
- Smartphone-based on-device artificial intelligence system for anterior segment eye disease screening
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Cataract
Comparison of Epinephrine and Phenylephrine/Ketorolac With Regards to Pupil Size
The objective of this study is to compare the maintenance of intraoperative mydriasis during cataract surgery between two drugs: epinephrine, which has routinely been used for decades, and Omidria, a newly FDA approved…
- Trial name
- NCT02895035
- Testing
- Phenylephrine-ketorolac, Epinephrine
- Volunteers
- 59 people
- Sponsor
- Milton S. Hershey Medical Center
Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus
Effect of Tropicamide 0.5% vs Tropicamide 1% on Intraocular Pressure of Diabetic Patients
The aim of this study is to compare the effect of tropicamide 0.5% and tropicamide 1% on intraocular pressure and anterior chamber parameters in patients with Diabetes Mellitus.
- Trial name
- NCT04932213
- Testing
- Tropicamide Ophthalmic
- Where
- Iran
- Volunteers
- 98 people
- Sponsor
- Semnan University of Medical Sciences
Acute Brain Injury, Pupillary Reflex Impaired
Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx
The use of quantitative, automated, infrared technology for pupillary examination has long been used in ophthalmology and anesthesiology research.
- Trial name
- ORANGE (NCT04490005)
- Testing
- pupillometry
- Where
- 14 sites in United States, Belgium and 6 more
- Volunteers
- 118 people
- Sponsor
- University of Milano Bicocca
Head Injury, Traumatic Brain Injury (TBI)
The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
After a head injury, many people find that exposure to light causes them increased discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue light, this study will investigate whether this phenomenon…
- Conditions
- Head Injury, Traumatic Brain Injury (TBI), Photosensitivity, Photophobia
- Trial name
- HIPP (NCT01942564)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Pupil Centroid Shift
Pupil Centroid Shift Compensation in Photorefractive Keratectomy Candidates
patients who are candidates of PRK will be recruited in this intrasubject randomized clinical trial. Inclusion criteria are myopia or myopic astigmatism with refractive cylinder.
- Trial name
- NCT03844178
- Testing
- The option for compensation of Pupil centroid shift was ON, The option for compensation of Pupil centroid shift was OFF, installation of Tetracaine 1%
- Where
- Iran
- Volunteers
- 104 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Caffeine, Alcohol
Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics
The goal of this study is to understand how caffeine and alcohol affect the ocular and physiological systems, especially how the pupil (the aperture in the colored part of the eye) responds to light.
- Conditions
- Caffeine, Alcohol, Pupillary Response, Eye Movements
- Trial name
- PAC (NCT07625358)
- Testing
- Caffeine administration, Alcohol (Ethanol)
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy
The Effect of Topical Treatment With Combigan Compared to Timolol and Brimonidine on Pupil Diameter
In this study we will explore the combined effect of Brimonidine and Timolol 0.5% (Combigan) eye drops on pupil dilation. It is a well studied phenoma that Brimonidine and a miotic effect on the pupil, however the combined effect…
- Trial name
- NCT02214680
- Testing
- Combigan (Combination of Brimonidine and Timolol), Timolol
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Mydriasis, Dilation
Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis
The objectives of this study are: To evaluate the efficacy of Nyxol to expedite the reversal of pharmacologically-induced mydriasis across multiple mydriatic agents with an emphasis on phenylephrine To evaluate the efficacy of…
- Trial name
- NCT04620213
- Testing
- Phentolamine Ophthalmic Solution 0.75%
- Where
- 12 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc