Clinical trials: Pupil Constriction
Pupillary Constriction, Accomodation
Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children
The study aims at reversing pupillary dilatation. and cycloplegia in children undergoing cycloplegic refraction for eyeglasses prescription and ocular examination.
- Trial name
- NCT07012512
- Testing
- Use of phentolamine eye drops to reverse cycloplegia, Pilocarpine 0.1%, Combination of pilocarpine 0.1% and phentolamine 0.75%
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Regional Anesthesia, Horner Syndrome
Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block
The purpose of this study is to assess cerebral blood flow velocity (CBFV) following regional anesthesia for shoulder surgery. The results of this study will help to further understand the physiologic effect of the interscalene…
- Conditions
- Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
- Trial name
- CBF-TCD (NCT04642612)
- Testing
- TCD Measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Small Pupil
Evaluation of an Iris Dilatation Ring in Cataract Surgery (ADICC-ID)
During cataract surgery, it is necessary to dilate the iris in order to remove the crystalline lens and position the implant. The diameter of the optical implant being 6 mm, in case of capsulorhexis crystalline access 5.5 mm, the…
- Trial name
- ADICC-ID (NCT02434588)
- Testing
- Bhattacharjee ring
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Children Brain Injury
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Intracranial hypertension (ICH) is a common and serious complication in children admitted to pediatric intensive care units. It is primarily caused by traumatic brain injury but can also result from brain malformations, brain…
- Trial name
- OSMOPUPILLO (NCT06642896)
- Testing
- pupillometer
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Horner's Syndrome, Stroke
Pupillometry in Horner's Syndrome
Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the…
- Conditions
- Horner's Syndrome, Stroke, Dissection Carotid Artery
- Trial name
- NCT02978079
- Testing
- Automated pupillometry
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- University of Zurich
Cataract
Topical Bromfenac for Intraoperative Miosis and Pain Reduction
To evaluate the effect of bromfenac ophthalmic solution 0.09% for reduction of intraoperative miosis and pain in patient who have undergone femtosecond laser-assisted cataract surgery.
- Trial name
- NCT03831984
- Testing
- 0,09% Bromfenac, 0,1% sodium hyaluronate
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de La Luz
Horner's Syndrome
Horner's SD After Thoracic Epidural Block
This study prospectively evaluates the incidence of Horner's syndrome after thoracic epidural anesthesia following continuous thoracic epidural analgesia for mastectomy.
- Trial name
- NCT02130739
- Testing
- thoracic epidural anesthesia, mastectomy, Ropivacaine
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Soonchunhyang University Hospital
Pupil Constriction, Iris Floppiness
Clinical Factors Associated Floppy Iris
This study is planned to investigate the incidence of intraoperative floppy iris and its relationship with pseudoexfoliation, diabetes, hypertension as well as systemic alpha-1 adrenergic blocker use.
- Conditions
- Pupil Constriction, Iris Floppiness, Iris Prolapsus From the Wound
- Trial name
- NCT00472888
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Baskent University
Cataract, Miosis
Nepafenac Versus Ketorolac Eye Drops in Prevention of Intraoperative Miosis During Cataract Surgery
This study aim at determining the efficacy of Nepafenac and Ketorolac in obtaining adequate intraoperative mydriasis and preventing miosis during cataract surgery.
- Trial name
- NCT03851172
- Testing
- Ketorolac Ophthalmic, Nepafenac Ophthalmic, Cyclopentolate Ophthalmic
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Small Pupil, Cataract
Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases
To evaluate the intraoperative stability, safety and overall efficacy of the Canabrava Ring (AJL - SPAIN) when used to expand pupils with less diameter than 5 mm and pupils with sphincter synechiae.
- Trial name
- NCT03206983
- Testing
- Cana's Ring
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Santa Casa de Misericórdia de Belo Horizonte
Horner Syndrome
Exploration of Pupil Dilation in Horner's Patients Taking Flomax
This study is evaluating the pupil dilation of Horner's Patients who have ever taken an alpha blocker such as Tamsulosin. Patients will undergo eye dilation as would occur at a yearly eye examination, but their pupil dilation…
- Trial name
- NCT03615508
- Testing
- 10% phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Horner's Syndrome
Clinical Efficacy of Supraclavicular Block for Arthroscopic Shoulder Surgery
The aim of this study is to compare the efficacy of supraclavicular and interscalene brachial plexus blocks in the patients undergoing arthroscopic shoulder surgery.
- Trial name
- NCT01958801
- Testing
- Supraclavicular block, Interscalene block
- Where
- South Korea
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Daegu Catholic University Medical Center
Brachial Plexus Block, Horner Syndrome
The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity
This study evaluates the effects of Horner's syndrome on cardiac autonomic nervous activity after interscalene brachial plexus block.
- Conditions
- Brachial Plexus Block, Horner Syndrome, Autonomic Imbalance
- Trial name
- NCT03514342
- Testing
- Interscalene brachial plexus block, 0.75% ropivacaine
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Daegu Catholic University Medical Center
Pupil Constriction
Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia
Randomized contralateral eye study to evaluate the effect of one-time dosing of NV701 versus commercially available 1.25% pilocarpine solution on pupil size.
- Trial name
- NCT06783686
- Testing
- NV701, Pilocarpine 1.25% Eye drop
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Novus Vision LLC
Cataract
Cytokines in Femtosecond Laser-assisted Cataract Surgery
The investigators performed the current study to compare: 1) the pain scores by Visual Analogue Scale; 2) the cytokines concentrations in aqueous humor by human cytokine antibody array; 3) the prostaglandin E2 (PGE2)…
- Trial name
- NCT05511506
- Testing
- aqueous humor collection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glaucoma, Cataract
Outcome of Small Pupil Phacotrabeculectomy in Persons With Glaucoma and Cataract
Small pupils are not uncommon in situations requiring surgical intervention for glaucoma and cataract. Inadequate binocular view during combined trabeculaectomy and glaucoma surgery needs to be overcome by additional iris…
- Trial name
- NCT00434707
- Volunteers
- 70 people
- Sponsor
- Aravind Medical Research Foundation
Opioid Toxicity, Pupillary Miosis
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60.
- Conditions
- Opioid Toxicity, Pupillary Miosis, Respiratory Depression
- Trial name
- NCT05391555
- Testing
- Remifentanil Hydrochloride, Pupillometry measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cataract
Comparative Study on Changes in Anterior Chamber Cytokines, Oxidative Stress, and Pupil Size After LenSx and Z8 Femtosecond Lasers
Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency…
- Trial name
- NCT06649799
- Testing
- LenSx, Z8
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract, Lens Subluxation
Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery
To study the efficacy of an ocular bandage contact lens for the treatment of dry eye after complicated and combined cataract surgery
- Conditions
- Cataract, Lens Subluxation, Hypermature Cataract, Corneal Opacity
- Trial name
- NCT04120389
- Testing
- bandage contact lenses(PureVision; Bausch & Lomb Inc., Rochester, NY), phacoemulsification
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Presbyopia, Near Vision
Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia
A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Phase 3 Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Treatment of Presbyopia
- Conditions
- Presbyopia, Near Vision, Miosis, Eye Diseases
- Trial name
- NCT06045299
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution
- Where
- 19 sites in China
- Volunteers
- 300 people
- Sponsor
- Corxel Pharmaceuticals