Clinical trials: Quantification
PHYSIOLOGICAL PHENOMENA, Homeostasis
Truway Whole-Body Digital Twin and Physiologic Resilience Study (TRU-OMNIBODY)
TRU-OMNIBODY is a prospective observational study designed to develop and independently validate a research-only whole-body digital twin.
- Conditions
- PHYSIOLOGICAL PHENOMENA, Homeostasis, Physical Functional Performance, Cardiorespiratory Fitness
- Trial name
- TRU-OMNIBODY (NCT07805044)
- Testing
- Standardized Physiologic Resilience Challenge, Multimodal Whole-Body Physiologic Monitoring, Research-Only Whole-Body Digital Twin Analysis
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Metabolism of Neramexane
A Single Center, Open-Label Study to Quantify Metabolites of [14C]-Neramexane in Plasma and Urine in Healthy Male Subjects
A Single Center, Open-Label Study to quantify metabolites of [14C]-Neramexane in plasma and urine in Healthy Male Subjects
- Trial name
- NCT01109680
- Testing
- Neramexane
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Periodontal Diseases
Deep Learning-Based Measurement of Keratinized Gingiva Width Using Smartphone-Acquired Clinical Images
This study aims to develop and validate an artificial intelligence-based system for automated measurement of keratinized gingiva width using smartphone-acquired intraoral clinical photographs.
- Trial name
- NCT07689552
- Testing
- Artificial Intelligence-Based Keratinized Gingiva Width Assessment
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Disorder of Consciousness
A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness
The research contains two parts. Part 1: To explore whether EEG responses to zolpidem can assess consciousness circuit integrity and predict the evolution of consciousness in patients with prolonged disorders of consciousness…
- Trial name
- NCT02948660
- Testing
- Zolpidem Tartrate Tablets
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
COPD, Healthy
Study of Airflow in the Lungs Using Helium MRI
Computer simulations are being developed to predict air flow abnormalities in the airways of patients with lung disease. The purpose of this study is to obtain actual gas flow measurements in the lungs of healthy patients and…
- Conditions
- COPD, Healthy, Constrictive Bronchitis
- Trial name
- NCT02154568
- Testing
- hyperpolarized helium-3 gas with MRI of the chest
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy
Quantification of Exhaled Particles to Identify Airborne Transmission Risks of COVID-19
In this study, the aerosols emitted during various respiratory activities will be quantified in healthy subjects. The differences in aerosol size spectrum and number during tidal breathing, speaking, coughing and singing will be…
- Trial name
- QUELLE (NCT04771585)
- Testing
- Community Mask, Surgical Mask, FFP2 respirator
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Diabetes, Obesity
Multi-Tracer PET Quantitation of Insulin Action in Muscle (Phase 1, Phase 2, Phase 3, Phase 4)
The purpose of this research is to develop a new method to study insulin action using positron emission tomography (PET). Insulin is the hormone made by your body to control the blood sugar level.
- Trial name
- NCT00222885
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Lung Cancer
Blood Samples From Patients With Non-Small Cell Lung Cancer and From Healthy Volunteers
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897234
- Testing
- Mass Spectrometry
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Oxygen Deficiency
Quantification of Clinically Relevant Drug Induced Changes in HbO2 Affinity
The presented study is an experimental in-vitro study without intervention in-vivo. The effects of nitric oxide and prostacyclins, 5-hydroxymethylfurfural and alpha-ketoglutarate, volatile anaesthetics on haemoglobin oxygen…
- Trial name
- NCT04612270
- Testing
- Venous blood collection
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Liver Diseases
Liver Micro Flow - MRI
This study integrates and evaluates a series of novel MRI methods for quantifying blood perfusion and tissue microstructure. The proposed perfusion and microstructure measures may provide biomarkers for fibrosis, cirrhosis…
- Trial name
- NCT07634939
- Testing
- Novel MRI Software, Ensure Plus Nutrition Shake
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Dyskinesias, Movement Disorders
Developing Objective Measures of Levodopa Induced Dyskinesia: (Study 1)
The ultimate goal of this proposal is to reduce dyskinesia in Parkinson's Disease (PD) patients. Dyskinesias are abnormal movements, often caused by the standard treatment for PD symptoms, levodopa.
- Conditions
- Dyskinesias, Movement Disorders, Parkinson Disease
- Trial name
- NCT00467597
- Testing
- Levodopa (delivered intravenously)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic Pain
Expanded Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain
PainQx is conducting a study to collect electroencephalography (EEG) data from 250 people with chronic pain and 50 healthy controls in order to develop algorithms that will objectively assess the level of pain a person is…
- Trial name
- NCT04585451
- Testing
- ALGOS System
- Where
- 5 sites in United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- PainQx, Inc
Dysexecutive Syndrome
Study for the Quantification in Ecological Conditions of Sensorimotor and Dysexecutive Disorders in Cerebral Palsy Patients
Executive functions are defined as the mental functions necessary for an individual to adapt to a complex or new environment that requires freedom from automatic and routine behavior.
- Trial name
- SDS2 (NCT05017051)
- Testing
- Chocolate cake, Lego model, Measurement of sensorimotor abilities
- Where
- France
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Pulmonary Hypertension
Integrated Diagnostics Characterization of Right Ventricular Diastolic Flow Dynamics in Pulmonary Arterial Hypertension
Pulmonary hypertension (PH) is a condition in which high blood pressure develops in the lungs and right side of the heart. People with PH suffer from shortness of breath, chest pain, heart failure, heart rhythm problems, and…
- Trial name
- NCT01491646
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Treatment for Opioid Use Disorder
A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals
To train a machine learning model/algorithm for an evaluation of the use of biometric data captured at the wrist for the identification of acute opioid use events and the quantification of opioid withdrawal in opioid dependent…
- Trial name
- NCT07405398
- Testing
- Train and evaluate the accuracy and reliability of the Strength Band Platform in identifying acute opioid dosing events from time-stamped biometric data collected from wrist-worn devices.
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- OpiAID
Dental Plaque (Diagnosis), Dental Plaque Imaging Methods
Digital Quantification of Dental Plaque Based on Intraoral Scanner Images
This diagnostic validation study aims to develop and validate a digital method for dental biofilm quantification using three-dimensional images obtained by an intraoral scanner.
- Conditions
- Dental Plaque (Diagnosis), Dental Plaque Imaging Methods, Dental Plaque, Gingivitis
- Trial name
- NCT07152314
- Testing
- Digital plaque quantification using intraoral scanner
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guarulhos
Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH)
Simultaneous Quantification of Liver Fat Content, Fatty Acid Composition, and Fibrosis Using Spin-lock MRI for Steatohepatitis Assessment
Non-alcoholic fatty liver disease is a major health problem worldwide. It includes simple steatosis and NASH which has inflammation in the liver, with or without fibrosis.
- Trial name
- NCT05384652
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Idiopathic Parkinson's Disease
Vascular Abnormalities in Idiopathic Parkinson's Disease
The purpose of this study is to use non-invasive Magnetic Resonance Imaging (MRI) scans to investigate venous insufficiency, brain iron levels and white matter hyperintensities (WMHs) to determine if there is direct correlation…
- Trial name
- IPD (NCT02045420)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Parkinson Disease
Quantification Tools for a Novel Tau PET Marker in a Rare Neurological Disease: 18F-PI-2620 in Progressive Supranuclear Palsy
The aim of this clinical trial is to explore the potential of novel 2nd generation tau PET radiotracers as biomarkers in cases suggestive of progressive supranuclear palsy (PSP), an atypical form of parkinsonism.
- Trial name
- Quanti-TAU-PET (NCT07105384)
- Testing
- Radiotracer
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Atrial Arrhythmia
The Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study (Smart in OAC - AFNET 9)
This feasibility study will develop and evaluate pathways to identify participants with wearable-detected absoulute Arrhythmia (AA) and to enable local study teams to contact them regarding participation in a controlled trial of…
- Trial name
- Smart in OAC (NCT04579159)
- Testing
- Preventicus heartbeat app in combination with wearables
- Where
- 4 sites in Germany, Poland and 1 more
- Volunteers
- 882 people, healthy volunteers welcome
- Sponsor
- Atrial Fibrillation Network