Clinical trials: Quantification
Parkinson Disease
A Novel Measurement Concept to Objectively Quantify Severity of Vocal and Speech Related Symptoms Associated With Parkinson's Disease
The aim of this research program is to develop and validate a smartphone app-based digital measurement concept that: Objectively quantifies the severity of Parkinson's Disease (PD) related vocal and speech symptoms; Accurately…
- Trial name
- Voice-PD (NCT05421832)
- Testing
- Digital Speech Application
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy
Quantification and Repeatability of Magnetic Stimulation
In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.
- Trial name
- NCT05302752
- Testing
- Magnetic phrenic nerve stimulation
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Airway Obstruction
One Minute Heart Rate Variability Quantification in Airway Obstruction Model
40 healthy volunteers underwent a trial of obstructed breathing through an eighteen cm long, four mm internal diameter tube. Heart rate was recorded during three consecutive sets comprised of one minute control followed by one…
- Trial name
- RRV Airway (NCT03733704)
- Testing
- Heart rate variability analysis
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Metabolism Disorder
Cold Induced Futile Cycles In White Adipose Tissue
Investigation of futile cycles in white adipose tissue under cold conditions for thermogenesis using two substitutes for glucose metabolism (18F-FDG and 13C-Glucose).
- Trial name
- Metabol (NCT04614116)
- Testing
- External cooling, FDG PET/CT, 13C-Glucose injection
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baden
Huntington Disease
iMagemHTT: FIH Evaluation of Novel Mutant Huntingtin PET Radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626
This is a FIH (first-in-human) adaptive PET (Positron Emission Tomography) imaging study to explore the binding and kinetic properties of two potential mutant huntingtin (mHTT) radioligands; [¹¹C]CHDI-00485180-R and…
- Trial name
- NCT03810898
- Testing
- Radioligand [¹¹C]CHDI-00485180-R, Radioligand [¹¹C]CHDI-00485626
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Huntington Disease, HD
iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009
This is a FIH (first-in-human) study to evaluate the clinical utility of the radioligand [11C]CHDI-00491009 as a PET tracer that binds specifically to mutant huntingtin (mHTT) aggregates in Huntington's disease (HD).
- Conditions
- Huntington Disease, HD, PET Tracer, Positron Emission Tomography
- Trial name
- iMagemHTT-009 (NCT06634628)
- Testing
- Radioligand [11C]CHDI-00491009
- Where
- Belgium
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Aged
Quantification of Ketosis After Intake of Coconut Oil and Caprylic Acid-With and Without Glucose-After a 12-hour Fast
In a cross-over design, 15 participants, age 65-75, will be tested in six different arms in a randomised order. After a 12-hour fast participants will be served 2.5 dl coffee with 15 g cream + 30-50 g of different fatty acids…
- Trial name
- NCT03904433
- Testing
- Coconut oil, Caprylic acid, Sunflower oil
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Autonomic Dysfunction, Autonomic Imbalance
Non-Invasive Bioelectronic Analytics
Biomarkers can be evaluated to provide information about disease presence or intensity and treatment efficacy. By recording these biomarkers through noninvasive clinical techniques, it is possible to gain information about the…
- Conditions
- Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
- Trial name
- NIBA (NCT04100486)
- Testing
- Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Sleep Bruxism, Diagnosis
Validation of a Diagnostic Method for Quantification of Sleep Bruxism
This study aims to validate a new diagnostic method for quantification and monitoring of sleep bruxism.
- Trial name
- DIABRUX (NCT03325920)
- Testing
- DIABRUX
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
HIV/AIDS
Quantification of Estradiol's Impact on Nucleotides in Cellular Populations of the Lower GI Tract
Purpose: To Assess the impact of high and low in vivo estradiol exposure on PrEP (Pre-exposure prophylaxis) nucleotide concentrations in different cellular populations of the lower GI (gastrointestinal) tract and to quantify the…
- Trial name
- NCT03917420
- Testing
- Tenofovir 300Mg Oral Tablet, Emtricitabine 200 MG
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Sensorineural Hearing Loss, Hearing Loss
Quantification of Visually Evoked Cortical Potentials in Individuals With Hearing Loss
This research is being done to determine whether a test that measures a "Visual Evoked Potential" can be used in a new way for individuals that have hearing loss.
- Trial name
- NCT05107466
- Testing
- P300 Visually evoked potential
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center