Clinical trials: RDS
Acute Respiratory Distress Syndrome
The ARISE Study - Use of Vertical Positioning
The pilot study will randomize 40 ARDS patients who if proning were required would be randomized to upright bed positioning or to stand of care with bed in the head of bed elevation position
- Trial name
- ARISE (NCT07025421)
- Testing
- Intervention Upright Bed positioning
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Respiratory Distress Syndrome in Premature Infant
Physiological Changes With High-Flow Nasal Cannula
To measure changes in physiologic parameters in extremely low birthweight (ELBW) infants on high-flow nasal cannula compared to nasal continuous positive airway pressure (nCPAP).
- Trial name
- NCT03700606
- Testing
- High flow nasal cannula, Nasal CPAP
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Sharp HealthCare
ARDS (Acute Respiratory Distress Syndrome)
Lung EIT Image Guide Ventilation in ARDS
The goal of this multi-center randomized controlled clinical trial is to learn if an individualized, bedside electrical impedance tomography (EIT)-guided ventilation strategy (including EIT-guided prone positioning and PEEP…
- Trial name
- NCT07309783
- Testing
- Recruitment maneuver and PEEP setting guided by EIT, PEEP setting according to routine practice, Prone positioning guided by EIT
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome
Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
- Trial name
- ELSE (NCT03281473)
- Testing
- Strategy 1, Strategy 2
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Lung Diseases, Respiratory Distress Syndrome
Human Surfactant Treatment of Respiratory Distress Syndrome Bicenter Trial
To determine if surfactant administration at birth in infants at high risk for respiratory distress syndrome (RDS) modified the clinical course of the syndrome.
- Trial name
- NCT00000570
- Testing
- pulmonary surfactant
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Prematurity, Respiratory Distress Syndrome, Newborn
Will CPAP Reduce Length Of Respiratory Support In Premature Infants?
In Canada each year, there are approximately 800 infants born between 28 and 32 weeks gestation. Up to 60% of these infants will require breathing tube placement for Respiratory Distress Syndrome or RDS.
- Trial name
- OLIVIA (NCT00486395)
- Testing
- CPAP, Mechanical ventilation
- Where
- 6 sites in Canada
- Volunteers
- 126 people
- Sponsor
- Children's & Women's Health Centre of British Columbia
ARDS, Human
Prone-Supine Study II: The Effect of Prone Positioning for Patients Affected by Acute Respiratory Distress Syndrome
The purpose of this study is to determine whether prone positioning is effective in improving survival in patients affected by acute respiratory distress syndrome (ARDS).
- Trial name
- NCT00159939
- Testing
- prone positioning
- Where
- 17 sites in Italy
- Volunteers
- 344 people
- Sponsor
- Policlinico Hospital
Bronchopulmonary Dysplasia (BPD)
Efficacy of Intrathecal Administration of Budesonide to Prevent Bronchopulmonary Dysplasia
The goal of this clinical trial is to learn if budesonide works to prevent bronchopulmonary dysplasia in newborn less than 32 weeks gestational age or birth weight less than 1500 g with respiratory distress syndrome who needs…
- Trial name
- NCT07725575
- Testing
- Experimental
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Indonesia
Acute Respiratory Distress Syndrome
Glucocorticoid Therapy for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of inflammatory lung injury characterized by increased pulmonary vascular permeability, loss of aerated lung tissue, severe hypoxemia and impaired compliance.
- Trial name
- NCT05401812
- Testing
- Intravenous glucocorticoid therapy
- Sponsor
- National Taiwan University Hospital
Respiratory Failure
Regional Lung Inflammation and Expansion in Mechanically Ventilated Patients - a PET/CT Study
The goal of this study is to investigate acute respiratory distress syndrome (ARDS) and septic lung with positron emission tomography (PET) imaging and to examine the distribution of inflammation, as measured by neutrophil…
- Trial name
- NCT01806532
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Neonatal Respiratory Distress
Effect of Antenatal Steroid on Pulmonary Artery Blood Flow
The aim of this study is to determine the effect of administering antenatal steroids in term fetuses on the blood flow in the fetal pulmonary artery, and to correlate these findings with clinical data obtained after birth…
- Trial name
- NCT02978976
- Testing
- Betamethasone, saline
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Pneumonia, Viral
Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia
Severe Acute Respiratory Syndrome (SARS) SARS-CoV-2, name of the Coronavirus Group of international Committee on taxonomy of viruses, is an emerging virus from the family of coronaviridae, responsible for the COVID-19 pandemic.
- Trial name
- PULCO-19 (NCT04422613)
- Testing
- pulmonary anomalies 4 months after documented COVID-19 pneumonia
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Toulouse
Intubation, Intubation Complications
A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants
Many newborn babies have difficulty breathing. When babies need a lot of help, a doctor will intubate them - i.e. put a tube into their windpipe (trachea) - so that they can be given support with a breathing machine.
- Conditions
- Intubation, Intubation Complications, Infant, Newborn, Infant Respiratory Distress Syndrome
- Trial name
- NEU-VODE (NCT06757543)
- Testing
- Video laryngoscopy, Direct laryngoscopy with standard laryngoscope
- Where
- 17 sites in Croatia, Czechia and 8 more
- Volunteers
- 840 people
- Sponsor
- University College Dublin
SIRS, Cytokine Storm
Cytokine Hemoadsorption in ECMO Patients
Cytokine hemoadsorption is a novel therapy used to improve outcome in critically ill patients with a dysregulated cytokine response and hemodynamic instability.
- Conditions
- SIRS, Cytokine Storm, Cardiogenic Shock, Cardiac Arrest
- Trial name
- NCT04901338
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Respiratory Distress Syndrome in Premature Infant
Comparison of Two Nasal Interface for CPAP in Preterm
Continuous distending airway pressure (CPAP) has gained popularity as a means to provide non-invasive respiratory support in neonates to reduce ventilator induced lung injury (VILI).
- Trial name
- NCT03212508
- Testing
- RAM cannula and Hudson prongs
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Covid19, Post Traumatic Stress Disorder
Quality of Life After COVID-19 Related Acute respIratory Distress Syndrome Among ICU Survivors Patients in Italy: the ODISSEA Study.
Acute respiratory insufficiency is one of the principal causes of intensive care admission for COVID 19 positive patients. This may determine a variable mortality rate ranging from 25-30%.
- Conditions
- Covid19, Post Traumatic Stress Disorder, Quality of Life
- Trial name
- ODISSEA (NCT04860687)
- Where
- 8 sites in Italy
- Volunteers
- 309 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
ARDS, Human, COVID
Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency
SARS-CoV-2, one of a family of human coronaviruses, was initially identified in December 2019 in Wuhan city. This new coronavirus causes a disease that has now been named COVID-19.
- Trial name
- COVIPOC (NCT04594668)
- Testing
- Senicapoc
- Where
- 4 sites in Denmark
- Volunteers
- 46 people
- Sponsor
- University of Aarhus
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Acute Respiratory Distress Syndrome
Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)
This trial is a prospective randomized multicenter trial that assigns patients to either a treatment for Acute Respiratory Distress Syndrome (ARDS) with an Extracorporal Membrane Oxygenation (ECMO) immediately after admission to…
- Trial name
- ELIEO (NCT04208126)
- Testing
- ECMO
- Where
- Germany
- Volunteers
- 508 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome
Inflammation During ECMO Therapy and ECMO Weaning
The goal of this interventional clinical trial is to compare patients who undergo ECMO therapy for treatment of acute respiratory distress syndrome (ARDS) and a randomized into one of two possible weaning strategy groups.
- Trial name
- ECMOWean (NCT05640635)
- Testing
- Ventilator weaning first, ECMO weaning first
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
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