Clinical trials: RDS
Acute Kidney Injury, COVID-19
Prediction of Acute Kidney Injury in Patients With COVID-19
The two biomarkers determined in urine, "Tissue Inhibitor of Metalloproteinases 2 (TIMP-2)" and "Insulin-like Growth Factor-Binding Protein 7 (IGFBP7)", can indicate the occurrence of Acute kidney injury (AKI) in cardiac surgery…
- Conditions
- Acute Kidney Injury, COVID-19, ARDS
- Trial name
- NCT04406688
- Where
- 13 sites in Germany, Italy and 3 more
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant Administration
This prospective randomized controlled study aims to determine if using a lung ultrasound score can lead to a faster diagnosis of severe respiratory distress syndrome and quicker administration of surfactant in moderately and…
- Trial name
- NCT07442669
- Testing
- Lung ultrasound
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hackensack Meridian Health
Acute Respiratory Distress Syndrome, Prone Position
Improvement of ARDS Ventilation-perfusion Matching by Prone Positioning Assessed by EIT
Acute Respiratory Distress Syndrome (ARDS) is a highly lethal disease with limited treatment options. In recent years, prone position ventilation has been shown to improve the mortality rate and lung injury of ARDS patients by…
- Conditions
- Acute Respiratory Distress Syndrome, Prone Position, Electrical Impedance Tomography
- Trial name
- NCT05765760
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Beijing Chao Yang Hospital
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Burns, Acute Lung Injury
Amphetamine Induced Adult Respiratory Distress Syndrome
Methamphetamine and amphetamine has various cardiovascular and central nervous system effects. Long-term use is associated with many adverse health effects including cardiomyopathy, hemorrhagic, and ischemic stroke.
- Conditions
- Burns, Acute Lung Injury, Acute Respiratory Distress Syndrome, Methamphetamine Abuse
- Trial name
- NCT05611385
- Testing
- Difference in development of Acute Lung Injury in Amphetamine positive and negative patients
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Arrowhead Regional Medical Center
Acute Lung Injury, Adult Respiratory Distress Syndrome
Assessing Respiratory Variability During Mechanical Ventilation in Acute Lung Injury (ALI)
Healthy biological systems are characterized by a normal range of "variability" in organ function. For example, many studies of heart rate clearly document that loss of the normal level of intrinsic, beat-to-beat variability in…
- Trial name
- NCT01083355
- Where
- United States
- Sponsor
- Boston Medical Center
Shock, Preterm Birth Complication
Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial
The goal of this clinical trial is to determine the effectiveness of early use of hydrocortisone (since the diagnosis of shock) for its resolution within the first 72 hours in premature infants under 1,500 g.
- Conditions
- Shock, Preterm Birth Complication, Preterm Intraventricular Hemorrhage, Asphyxia Perinatal
- Trial name
- NCT07248761
- Testing
- Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Respiratory Distress Syndrome
Non Inferiority Trial Investigating Surfactants Administered Via MIST
RESEARCH DESIGN Multicenter, randomized, controlled trial. RECRUITMENT Entry criteria Preterm infants 28-35 6/7 weeks' gestation and less than 48 hours of age who have a clinical diagnosis of respiratory distress syndrome.
- Trial name
- Niftisurf (NCT06074380)
- Testing
- MIST surfactant
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- Endeavor Health
Acute Respiratory Distress Syndrome
Practices of Prone Positioning Ventilation in Patients With Moderate-to-Severe ARDS in Intensive Care Units: A Registry-Based Observational Study
Acute respiratory distress syndrome (ARDS) is a major cause of mortality in intensive care units. Prone position ventilation (PPV) is an important component of ARDS management and has been shown to reduce mortality in patients…
- Trial name
- PPV SAFE (NCT07284888)
- Testing
- Prone position ventilation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Southeast University, China
Severe Pneumonia, Acute Respiratory Distress Syndrome
Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study
Low and middle-income countries (LMICs) urgently need cost-effective adaptive technologies to provide CPAP. The lead investigator has designed a device that has already been approved by the Directorate General of Drug…
- Conditions
- Severe Pneumonia, Acute Respiratory Distress Syndrome, Covid19
- Trial name
- Adult-bCPAP (NCT05158842)
- Testing
- Adult bubble CPAP oxygen therapy device
- Where
- 2 sites in Bangladesh
- Volunteers
- 20 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Respiratory Distress Syndrome (ARDS)
Assessment of the Reproducibility of the Recruitment-to-inflation Ratio (R/I Ratio) Measurement in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a severe lung condition that often requires invasive mechanical ventilation in the intensive care unit.
- Trial name
- RIRR (NCT07666503)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure
The study is a randomized controlled, open-label trial comparing subcutaneous Zilucoplan® with standard of care to standard of care alone.
- Trial name
- ZILU-COV (NCT04382755)
- Testing
- Zilucoplan®
- Where
- 9 sites in Belgium
- Volunteers
- 81 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Distress Syndrome
A Multicenter, Random Control Study :Early Use of Airway Pressure Release Ventilation (APRVplus) Protocol in ARDS
Animal experimentals have shown that the more physiology-driven airway pressure release ventilation (APRV) methodologies in ARDS may significantly improve alveolar recruitment and gas exchange, increased homogeneity, and…
- Trial name
- NCT03549910
- Testing
- APRVplus protocol, Low tidal volume ventilation
- Where
- China
- Volunteers
- 840 people
- Sponsor
- West China Hospital
Respiratory Mechanics, Respiration, Artificial
Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19
Research question: Are the ventilatory variables related to mechanical power associated with the outcome of subjects who received mechanical ventilation (MV) for Acute Respiratory Distress Syndrome (ARDS) secondary to pneumonia…
- Conditions
- Respiratory Mechanics, Respiration, Artificial, Respiratory Distress Syndrome
- Trial name
- NCT05946525
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Hospital Donación Francisco Santojanni
ARDS
Effects of TCAV and Volume Control Ventilation on the Distribution of Aerated Lung Parenchyma in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a severe form of acute respiratory failure with mortality rates reaching as high as 35%.
- Trial name
- TCAV-CT (NCT05874973)
- Testing
- Time-controlled adaptative ventilation (TCAV), Volume-controlled ventilation (VCV)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Central Hospital, Nancy, France
Acute Respiratory Distress Syndrome, SARS-CoV-2
Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Acute Respiratory Distress Syndrome (ARDS) Associated With at Least Severe COVID-19
Evaluation of the safety, tolerability, and pharmacokinetics of PLN-74809 in participants with acute respiratory distress syndrome (ARDS) associated with at least severe COVID-19
- Trial name
- NCT04565249
- Testing
- PLN-74809
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- Pliant Therapeutics, Inc.
Sepsis, Acute Respiratory Distress Syndrome (ARDS)
Evaluating Artificial Intelligence-Based Clinical Decision Support for Sepsis and ARDS
Sepsis and acute respiratory distress syndrome (ARDS) are common in intensive care units. Managing sepsis and ARDS is inherently complex and requires making numerous decisions under uncertainty.
- Trial name
- NCT07025096
- Testing
- Artifical Intelligence-Generated Treatment Recommendations
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- University of Pennsylvania
Respiratory Failure, Acute Respiratory Distress Syndrome
Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome (ARDS) is one of common clinical critically diseases. In the United States, the incidence of ARDS reaches 31%, which is one of the main causes of death in patients.
- Trial name
- APT (NCT02178982)
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Southeast University, China
COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic
University Hospital of Ioannina COVID-19 (Coronavirus Disease 2019) Registry
COVID-19 (Coronavirus Disease 2019) Registry of University Hospital of Ioannina. Retrospective datasource registry with quantitative and qualitative patient data from the hospital medical records.
- Conditions
- COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05534074
- Where
- Greece
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Ioannina
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