Clinical trials: Radiation Cystitis
Radiation Cystitis
Clinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Combined With Sodium Hyaluronate Intravesical Instillation in the Treatment of Radiation Cystitis
The goal of this clinical trial is to learn whether intravesical instillation of human umbilical cord mesenchymal stem cell-derived exosomes combined with sodium hyaluronate is safe and effective for treating radiation cystitis.
- Trial name
- NCT07665619
- Testing
- Exosomes (hUC-MSC-Exo), Sodium Hyaluronate (Hyalein), Normal Saline (0.9% NaCl)
- Volunteers
- 48 people
- Sponsor
- Fujian Medical University Union Hospital
Radiation Cystitis, Urinary Tract Infection (Diagnosis)
Chronic Radiation Cystitis and Effect of Hyperbaric Oxygen Therapy on Patient Reported Outcomes and Urine Inflammatory Biomarkers
Collection of urine, blood, and tissue samples from patients undergoing hyperbaric oxygen therapy
- Trial name
- NCT07368647
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rachel A. Moses
Radiation Cystitis
Radiation Cystitis Treated With Pentosan Polysulfate Sodium Trial
The purpose of this study is to evaluate the efficacy and safety of pentosan polysulfate sodium versus placebo and in patients with radiation cystitis who have received radiation therapy in pelvic region.
- Trial name
- NCT05245591
- Testing
- Pentosan Polysulfate Sodium 100 MG Oral Capsule
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Radiation Cystitis
Efficacy of Low-Intensity Shockwave Therapy in Treating Radiation Cystitis
Radiation-induced cystitis is a condition commonly seen in patients who have undergone radiation therapy, especially those treated in the pelvic region.
- Trial name
- NCT07016451
- Testing
- Li-ESWT, Medication
- Where
- Thailand
- Volunteers
- 25 people
- Sponsor
- Thanakrit Visuthikosol
Interstitial Cystitis, Recurrent Cystitis
Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation
This study aims to evaluate a catheter-free method for delivering medications directly into the bladder, known as intravesical instillation, which is commonly used to treat conditions such as interstitial cystitis/bladder pain…
- Conditions
- Interstitial Cystitis, Recurrent Cystitis, Haemorrhagic Cystitis, Bladder Cancer
- Trial name
- NOCATIN (NCT06719232)
- Testing
- Catheter-Free Intravesical Instillation with a special syringe adapter
- Where
- 2 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Jahn Ferenc South Pest Teaching Hospital
Hemorrhagic Cystitis
Chlorophyllin Tablets for Urinary Bleeding Following Radiation Therapy for Cancers of Pelvic Organs
To assess the efficacy of oral chlorophyllin tablets for urinary bleeding following radiation therapy for cancers of pelvic organs.
- Trial name
- CLARITY (NCT05348239)
- Testing
- Sodium Copper Chlorophyllin
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Tata Memorial Centre
Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN)
Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE)
Radiotherapy cures many cancers but can cause late radiation-induced tissue injury (LRTI), leading to long-term symptoms from the bladder and bowel and reduced health-related quality of life (HRQoL).
- Conditions
- Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN), Radiation Proctitis
- Trial name
- karolinskaUH (NCT07611864)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Cystitis, Radio Induced
Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial
The primary objective of this study is to assess the relief of symptoms after Hyperbaric Oxygen Therapy (HBOT) in patients with late radiation cystitis by having Expanded Prostate cancer Index Composite (EPIC)symptom estimation…
- Trial name
- RICH-ART (NCT01659723)
- Testing
- Hyperbaric Oxygen
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 75 people
- Sponsor
- Göteborg University
Hemorrhagic Cystitis
Tolerability and Efficacy of INSTYLAN in Subjects With Moderate to Severe Hemorrhagic Cystitis
The purpose of this study is to assess the efficacy and tolerability of INSTYLAN (Sodium Hyaluronate 80mg/50ml) in Patients with early or late symptoms of moderate to severe hemorrhagic cystitis caused by pelvic radiation therapy…
- Trial name
- NCT04696666
- Testing
- INSTYLAN (Sodium Hyaluronate 80mg/50ml)
- Where
- 10 sites in France
- Volunteers
- 30 people
- Sponsor
- LIDDE Therapeutics
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Pelvic Radiation Therapy, Radiation-induced Hemorrhagic Cystitis
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy
Patients receiving radiation therapy are still at risk for side effects due to off-target radiation damage of normal tissues The number of cancer patients is expected to increase from 14.1 million around the world in 2012 to 19.3…
- Trial name
- PRISME (NCT02814864)
- Testing
- Mesenchymal Stromal Cell (MSC) injections
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer
Multicentre International STudy for the Prevention With Ialuril® of Radio-induced Cystitis (MISTIC)
The study is randomized and it will be conducted in the field of routine clinical practice. A total of 100 consecutive patients planned to receive radiotherapy for prostate cancer will be enrolled.
- Trial name
- MISTIC (NCT03493997)
- Testing
- Radiotherapy+IAluril®+Ialuril Soft Gels®, Radiotherapy only
- Where
- 7 sites in Italy, Slovakia and 2 more
- Volunteers
- 100 people
- Sponsor
- Study Group for Urogenital Diseases, Italy
Radiation Injuries
Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries
The principle objective of this research is to more precisely determine the degree of benefit that hyperbaric oxygen therapy affords in the treatment of late radiation tissue injury. The study has eight* components.
- Trial name
- NCT00134628
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 248 people
- Sponsor
- National Baromedical Services
Radiation Cystitis, Non-valvular Atrial Fibrillation
Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding
The etiology of the radiation cystitis is a pelvic irradiation generally performed as part of the treatment of prostate cancer. The incidence is 50,000 new cases per year.
- Trial name
- HEMOCC (NCT04701749)
- Testing
- Percutaneous left atrial closure, No Percutaneous left atrial closure
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Radiation Cystitis, Prostate Cancer
Study of Serum and Urinary Biomarkers and Radiation Cystitis in Patients Treated With Radiotherapy for Localized Prostate Cancer
Prostate cancer represents the 1st diagnosed cancer in men, with 50400 new cases and 8100 deaths in 2018. Improved diagnostic and therapeutic strategies have led to a 3.7% decrease in mortality between 2010 and 2018 with a 5- and…
- Conditions
- Radiation Cystitis, Prostate Cancer, Radiotherapy Side Effect
- Trial name
- RABBIO (NCT05246774)
- Testing
- Biological sample collection, Questionnaires
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Bladder Cancer, Radiation Cystitis
Intravesical Hyaluronic Acid (HA) for Preventing Radiation Cystitis on Bladder Cancer
To evaluate the efficacy and safety of intravesical hyaluronic acid (HA) instillation therapy for the prevention of radiation-induced cystitis in patients undergoing radiotherapy for bladder cancer.
- Trial name
- NCT07125924
- Testing
- Blad-Care (sodium hyaluronate 1.6%, 800 mg/50 mL, BioPlus Co., Ltd.), Normal Saline (NS)
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea