Clinical trials: Radiation Effects
Hodgkin Disease
Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PET
Prognosis of patients with Hodgkin´s lymphoma (HL) has been improved significantly over the last decade. Therefore, the impact of treatment associated long-term toxicities and late effects such as second cancers increased.
- Trial name
- NCT00188149
- Testing
- Combined chemotherapy (ABVD, BACOPP-D), Radiation therapy
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Carl Gustav Carus
Oncology
Prophylactic Oral Vitamin D and Zinc for Radiation-Induced Oral Mucositis in Head and Neck Cancer
The main aim of this study was to evaluate clinically the effect of a combination between oral vitamin D and oral zinc in comparison to conventional therapy in prevention of radiotherapy-induced oral mucositis in Assiut…
- Trial name
- NCT06100692
- Testing
- Vitamin D
- Volunteers
- 100 people
- Sponsor
- Assiut University
Maximum Interincisal Opening
Effects of Exercise Therapy Adjuvant Device on Head and Neck Cancer Patients in the Treatment of Cancer Therapy Induced Trismus
Trismus is traditionally considered being a late effect of cancer therapy with functional deficits becoming clear in the first year after completing radiation therapy.
- Trial name
- NCT04740216
- Testing
- exercise therapy plus jaw device, exercise therapy
- Volunteers
- 130 people
- Sponsor
- Taipei Medical University
Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD)
Multichannel Vestibular Implant Early Feasibility Study
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady…
- Conditions
- Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth Diseases
- Trial name
- NCT02725463
- Testing
- Labyrinth Devices MVI™ Multichannel Vestibular Implant
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Carbon Monoxide Poisoning
Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy
Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome…
- Trial name
- COCARDIOTOX (NCT06549621)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Brest
Breast Cancer, Radio Dermatitis
Photobiomodulation in Radiodermatitis in People With Breast Cancer
Most breast cancer patients undergoing radiotherapy develop radiodermatitis, making it one of the most prevalent adverse events during cancer treatment.
- Trial name
- NCT06990165
- Testing
- Photobiomodulation
- Where
- 2 sites in Brazil
- Volunteers
- 148 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Radiotherapy Side Effect, Radiodermatitis
Thermal Imaging to Evaluate Skin Toxicity From Radiotherapy
A significant proportion of patients treated with whole-breast or head and neck radiotherapy will experience skin toxicity, i.e. skin dermatitis, which may lead to erythema, dry desquamation and wet desquamation.
- Trial name
- NCT04013711
- Testing
- Thermography
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Pancreatic Cancer Non-resectable
Effects of Folfirinox and Stereotactic Body Radiation Therapy for Advanced Pancreatic Cancer
This study wants to find out how safe and effective the use of Folfirinox combined with Stereotactic Body Radiation Therapy )(SBRT) is for the treatment of pancreatic cancer.
- Trial name
- BCC-RAD-13 (NCT02128100)
- Testing
- Folfirinox, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Louisville
Radiation Exposure
Digestive Endoscopy Suite Radiation Controlling Protective Strategies
ERCP is associated with radiation exposure to the endoscopist and staff, which may be significant at high volume programs despite the use of lead aprons.
- Trial name
- D-ERCP (NCT02063841)
- Testing
- lead-free protective drape containing bismuth and antimony (RADPAD®)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Yale University
Radiotherapy; Complications, Cardiotoxicity
Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients
The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity…
- Conditions
- Radiotherapy; Complications, Cardiotoxicity, Cancer, Lung Cancer
- Trial name
- NCT04896242
- Where
- Chile
- Volunteers
- 47 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as amifostine may protect normal cells from the side effects of chemotherapy and radiation…
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00003583
- Testing
- amifostine trihydrate, cisplatin, etoposide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Chronic Lymphocytic Leukemia, Atrial Fibrillation
Hypertension and Arrhythmias in CLL Patients Treated With BTK Inhibitors
Acalabrutinib and Zanabrutinib are highly effective drugs used to treat Chronic Lymphocytic Leukemia, but they are associated with high blood pressure and abnormal heart rhythms.
- Conditions
- Chronic Lymphocytic Leukemia, Atrial Fibrillation, Hypertension, Cardiotoxicity
- Trial name
- SENTINEL (NCT06211413)
- Testing
- no intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Complications of Bariatric Procedures, X-rays; Effects
The Use of X-ray in Bariatric Surgeries
examination of the importance of the use of X-ray in bariatric surgery outcome.
- Trial name
- NCT02813122
- Testing
- x-ray
- Where
- Israel
- Volunteers
- 8,000 people
- Sponsor
- Assuta Medical Center
Urinary Bladder Neoplasms, Uterine Cervical Neoplasms
Effect of Pelvic Radiotherapy on the Intestinal Microbiome and Metabolome
Eight in ten patients will develop bowel problems during radiotherapy, eg diarrhoea, pain and incontinence, half will develop difficult long-term bowel problems.
- Conditions
- Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Endometrial Neoplasms
- Trial name
- EPRIMM (NCT04995809)
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- The Christie NHS Foundation Trust
Osteoradionecrosis
The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis.
Osteoradionecrosis (ORN) is a severe delayed radiation-induced injury that can occur in patients whom have been subjected to radiotherapy for head and neck cancer. Hyperbaric oxygen treatment (HBO) is one treatment option.
- Trial name
- ORN (NCT04934644)
- Testing
- Hyperbaric oxygen treatment
- Where
- 2 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Göteborg University
Effects of Chemotherapy
Assessing Fertility Potential in Female Cancer Survivors
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers.
- Trial name
- NCT01143844
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Radiation Injuries, Cognitive Impairment
The Effect of Donepezil in Radiotherapy-related Cognitive Impairment.
Purpose: This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the therapeutic effects of donepezil in radiotherapy-related cognitive impairment.
- Trial name
- NCT03907371
- Testing
- Donepezil Hydrochloride
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Xerostomia
Effect of Low-level Laser Therapy on Salivary Flow, pH and Quality of Life in Irradiated Oropharyngeal Cancer Patients
There are multiple treatment modalities for head and neck cancer. They include radiation therapy, chemotherapy and surgery. Radiation therapy aims to control the tumor with minimum damage to adjacent tissues.
- Trial name
- NCT04738227
- Testing
- Low-Level Laser Therapy
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Ziauddin University
Lymphoma
Comparison Study of Doxorubicin Versus Epirubicin-induced Cardiotoxicity in Patients With DLBCL
The aim of this study is to compare CHOP versus CEOP-induced cardiotoxicity in patients with aggressive B-cell lymphoma. The hypothesis is epirubicin is associated with less cardiotoxicity without compromising the efficacy.
- Trial name
- NCT00854568
- Testing
- CEOP regimen, CHOP regimen
- Where
- China
- Volunteers
- 398 people
- Sponsor
- Fudan University
Prostate Cancer, Radiation Therapy
Radiosensitizing and Radioprotectve Effects of Curcumin in Prostate Cancer
Prostate cancer is the second most incident cancer among male population worldwide. Radiation therapy by itself or along with surgery and chemotherapy are the main treatments for prostate cancer however prostate cancer cells are…
- Trial name
- NCT01917890
- Testing
- Curcumin
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
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