Clinical trials: Radiation Effects
Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy
Effect of Bevacizumab on Radiation-induced Brain Necrosis in Patients With Nasopharyngeal Carcinoma
Bevacizumab may have a better effect on brain necrosis caused by radiotherapy.This randomized trial aims to investigate whether bevacizumab may alleviate radiation-induced brain necrosis in patients with nasopharyngeal carcinoma.
- Conditions
- Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy, Brain Necrosis
- Trial name
- BRAIN (NCT01621880)
- Testing
- bevacizumab, Corticosteroid
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Esophagus Cancer, Chemoradiation
Definitive (Chemo)Radiotherapy for Patients With Esophageal Cancer - 3JECROG R-01
The aim of this observational study is to retrospectively collect survival data for 3000 primary esophageal cancer patients from multicenter between January 2000 to present.
- Conditions
- Esophagus Cancer, Chemoradiation, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- NCT03298204
- Where
- China
- Volunteers
- 2,762 people
- Sponsor
- Chinese Academy of Medical Sciences
Merkel Carcinoma, Radiotherapy Side Effect
Prediction of Appearance of Late Cutaneous Side Effects After RadioTherapy
Search for blood predictive marker (s) for cutaneous radiosensitivity
- Trial name
- PAESCART (NCT03060226)
- Testing
- blood sample
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Francois Baclesse
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
RATIONALE: Donepezil may decrease the side effects caused by radiation therapy to the brain. PURPOSE: This clinical trial is studying how well donepezil works in treating young patients with primary brain tumors previously…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Children, Neurotoxicity
- Trial name
- NCT00452868
- Testing
- Donepezil
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Radiation, X-rays; Effects
EXTended pRotective Curtain Under Table to Reduce Operator RAdiation Dose in Percutaneous Coronary Procedures
Radiation dose to interventional cardiologists performing transradial percutaneous coronary procedures is higher compared to those performing transfemoral exams. The radiation dose seems particularly high at pelvic level.
- Conditions
- Radiation, X-rays; Effects, Coronary Disease
- Trial name
- EXTRA-RAD (NCT03259126)
- Testing
- SCUT
- Where
- Italy
- Volunteers
- 157 people
- Sponsor
- Ospedale Sandro Pertini, Roma
Prostatic Neoplasms Benign, Radiotherapy Side Effect
Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis
Men with high risk prostate cancer who underwent radiotherapy of the prostate/seminal vesicles or underwent postoperative radiotherapy including pelvic lymph nodes between 2010 and 2016 are analyzed retrospectively.
- Conditions
- Prostatic Neoplasms Benign, Radiotherapy Side Effect, Lymph Node Disease
- Trial name
- NCT02998619
- Testing
- Radiotherapy
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Kantonsspital Graubünden
Radiodermatitis, Breast Neoplasms
Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients
The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
- Conditions
- Radiodermatitis, Breast Neoplasms, Adverse Effect of Radiation Therapy
- Trial name
- NCT02922244
- Testing
- Control, Cucumber cream, Centella cream
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chulabhorn Cancer Center
Breast Neoplasm Female, Radiotherapy Side Effect
Gated Radiotherapy in Left Sided Breast Cancer Patients
To assess the need of respiratory gated radiotherapy in left sided breast cancer patients.
- Conditions
- Breast Neoplasm Female, Radiotherapy Side Effect, Heart Diseases
- Trial name
- GATTUM (NCT03534570)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Tumor, Effects of; Movement
Evaluation of Intrafractional Motion of Liver Tumors Using Markers
Radioopaque fiducial markers or electro-magnetic transponders will be implanted into or in close proximity of the tumor. During a radiotherapy treatment session image and/or signal acquisition will be performed by ultrasound…
- Conditions
- Tumor, Effects of; Movement, Radiation; Lesion
- Trial name
- ESMERALDA (NCT02095236)
- Testing
- organ motion
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Esophageal Cancer, Radiation Pneumonitis
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology
Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs.
- Conditions
- Esophageal Cancer, Radiation Pneumonitis, Pulmonary Fibrosis, Respiratory Failure
- Trial name
- NCT03462524
- Testing
- Esophagectomy
- Where
- 2 sites in Ireland
- Volunteers
- 384 people
- Sponsor
- St. James's Hospital, Ireland
Anemia, Cervical Adenocarcinoma
Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Anemia, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma
- Trial name
- NCT00017004
- Testing
- External Beam Radiation Therapy, Cisplatin, Internal Radiation Therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Gynecologic Oncology Group
Radiotherapy, Radiotherapy Side Effect
Pulsed Low Dose Rate Radiation Therapy for Gastric Cancer Patients With Peritoneal Metastasis
This phase II trial studies the side effects and response of pulsed low dose rate radiation therapy in treating gastric cancer patients with peritoneal metastasis.
- Conditions
- Radiotherapy, Radiotherapy Side Effect, Stomach Neoplasms
- Trial name
- NCT03061162
- Testing
- pulsed low dose rate radiation therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yang Yang
Cervical Spasm, Radiotherapy Side Effect
Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures
The main objective of the study is to estimate the efficiency and to determine the optimal dose of Botulinum toxin A, administered by intramuscular way in cervical spasms after radiotherapy, as well as the optimal sites for these…
- Conditions
- Cervical Spasm, Radiotherapy Side Effect, Botulinum Toxin
- Trial name
- NCT02986880
- Testing
- Botulinum toxin A
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Hopital Foch
Radiation; Adverse Effect, Pneumonitis
Predictors of Radiation Pneumonitis in Locally Advanced Lung Cancer Treated With Chemoradiation
Lung cancer [LC] is the leading cause of cancer death worldwide. The standard treatment of locally advanced lung cancer unresectable or marginally resectable is combination therapy with radical or preoperative chemoradiation.
- Trial name
- NCT01580579
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Melanoma, Effects of Immunotherapy
Trial of SBRT With Concurrent Ipilimumab in Metastatic Melanoma
The prognosis of advanced metastatic melanoma remains poor although a breakthrough has been achieved with the novel anti-CTLA-4 treatment (ipilimumab) for a subset of patients.
- Conditions
- Melanoma, Effects of Immunotherapy, Adverse Effect of Radiation Therapy
- Trial name
- NCT02406183
- Testing
- Stereotactic body radiotherapy (SBRT), Ipilimumab
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Radiotherapie
Breast Cancer, Adverse Effect of Radiation Therapy
Study to See Whether Breath-Hold Techniques During RT Are Effective in Helping to Improve Sparing of the Heart
The study hopes to determine whether patients with left-sided breast cancer are at an increased risk of cardiac changes due to radiation to the breast +/- Anthracycline-based chemotherapy +/- Herceptin and whether a deep…
- Trial name
- NCT02052102
- Testing
- Radiation therapy
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- AHS Cancer Control Alberta
Pediatric ALL, Radiotherapy Side Effect
Design and Evaluation of Care Environment and Technology at Pediatric Radiotherapy
The purpose of the study is to evaluate the effect of changes in the care environment in pediatric radiotherapy. The definitions of the changes is a part of the study, and is constructed in collaboration with the institute of…
- Trial name
- DUMBO (NCT02993978)
- Volunteers
- 57 people
- Sponsor
- Umeå University
Cognitive/Functional Effects, Delirium
Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer.
- Conditions
- Cognitive/Functional Effects, Delirium, Depression, Lung Cancer
- Trial name
- NCT00006349
- Testing
- vitamin E, donepezil hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 9 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00006012
- Testing
- filgrastim, amifostine trihydrate, cisplatin
- Where
- 84 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment
Sildenafil in Treating Erectile Dysfunction in Patients With Prostate Cancer
RATIONALE: Sildenafil may be effective in helping patients who have undergone treatment for prostate cancer to have an erection for sexual activity and may improve sexual satisfaction and quality of life.
- Conditions
- Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment, Radiation Toxicity, Sexual Dysfunction
- Trial name
- NCT00057759
- Testing
- sildenafil citrate
- Where
- 30 sites in United States
- Volunteers
- 115 people
- Sponsor
- Radiation Therapy Oncology Group