Clinical trials: Radiation Enteritis
Diarrhea, Radiation Enteritis
Pentosan Polysulfate in Treating Patients With Gastrointestinal Disturbance Caused by Radiation Therapy
RATIONALE: Pentosan polysulfate may be effective in treating side effects of radiation therapy to the abdomen or pelvis. It is not yet known whether pentosan polysulfate is more effective than no further therapy for treating…
- Trial name
- NCT00003825
- Testing
- pentosan polysulfate sodium, quality-of-life assessment
- Where
- 260 sites in United States, Canada
- Volunteers
- 174 people
- Sponsor
- Radiation Therapy Oncology Group
The Clinical Incidence of Low Triiodothyronine Syndrome
An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis
Radiation enteritis (RE) is by simple definition an inflammatory process occurring at the level of the intestines as a response to abdominal or pelvic radiation energy exposure.
- Trial name
- NCT02452073
- Testing
- Thyroid function tests
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shengxian Fan
Acute Radiation Enteritis
Gegen Qinlian Tang and Probiotics for Radiation Enteritis
The purpose of this clinical study is to evaluate whether Bifidobacterium Triple Viable Capsules, alone or in combination with Gegen Qinlian Decoction, can effectively prevent and treat acute radiation enteritis in patients…
- Trial name
- GQBT-RE (NCT06836960)
- Testing
- Probiotic Therapy With Gegen Qinlian Tang
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiujiang No.1 People's Hospital
Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
RATIONALE: Probiotic therapy may reduce or prevent gastrointestinal complications in patients undergoing chemotherapy and pelvic radiation therapy.
- Conditions
- Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction, Diarrhea, Fatigue
- Trial name
- NCT01473290
- Testing
- live freeze-dried lactic acid bacteria probiotic
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Cancer, Locally Advanced Rectal Cancer
A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational Analysis of Tumor Tissue
This clinical study investigates the anti-inflammatory and anti-cancer properties of a high-bioavailability formulation of curcumin (BCM-95) in patients with mid-to-low rectal cancer receiving neoadjuvant chemoradiotherapy…
- Conditions
- Rectal Cancer, Locally Advanced Rectal Cancer, Radiation-Induced Enteritis, Radiation Proctitis
- Trial name
- BCMRECRAD (NCT07248020)
- Testing
- Curcumin (BCM-95®)
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Radiation Enteritis
Prevention of Acute Radiation Enteritis With Glutamine
Ionizing radiation has cytotoxic effects, and is commonly used as treatment for neoplasm. A common adverse effect of radiation is acute diarrhoea.
- Trial name
- NCT00828399
- Testing
- Glutamine, Whole protein
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Castilla-León Health Service
Enteritis
A Dose Ranging Study of Delayed Release Beclomethasone for Prevention of Acute Enteritis in Patients With Rectal Cancer
The purpose of this study is to evaluate the safety and preliminary efficacy of four doses of SGX201 in subjects with rectal cancer treated with concurrent radiation and chemotherapy.
- Trial name
- NCT01073384
- Testing
- SGX201 (delayed release beclomethasone 17,21-dipropionate)
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Soligenix
Radiation Enteritis
CMTS0515-auWMT for Radiation Enteritis
This is a randomized controlled trial to explore the exploring the non-inferiority of CMTS0515-augmented WMT compared to WMT.
- Trial name
- NCT07331688
- Testing
- CMTS0515-augmented washed microbiota transplantation, Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Cancer, Diarrhea
Impact of Probiotics BIFILACT® on Diarrhea in Patients Treated With Pelvic Radiation
In this double-blinded randomized clinical trial study, investigators assessed probiotic used to prevent or delay radiation induced grade moderate to severe diarrhea with patient treated for pelvic cancer.
- Conditions
- Cancer, Diarrhea, Abdominal Pain, Quality of Life
- Trial name
- NCT01839721
- Testing
- Bifilact®
- Where
- Canada
- Volunteers
- 246 people
- Sponsor
- CHU de Quebec-Universite Laval
Anal Cancer, Colorectal Cancer
Octreotide in Preventing or Reducing Diarrhea in Patients Receiving Chemoradiotherapy for Anal or Rectal Cancer
RATIONALE: Octreotide may be effective in preventing or controlling diarrhea in patients who are undergoing chemoradiotherapy for anal or rectal cancer. It is not yet known whether octreotide is effective in treating diarrhea.
- Conditions
- Anal Cancer, Colorectal Cancer, Drug/Agent Toxicity by Tissue/Organ, Radiation Enteritis
- Trial name
- NCT00075868
- Testing
- octreotide acetate
- Where
- 112 sites in United States
- Volunteers
- 233 people
- Sponsor
- Radiation Therapy Oncology Group
Enteritis Caused by Radiation
Multiple Ascending Dose Study to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered SYN 020
This is a Phase 1, randomized, double-blind, placebo-controlled, multiple-ascending-dose study to assess the PK, safety, and tolerability of SYN-020 oral delayed release capsules (SYN 020) in healthy adults.
- Trial name
- NCT05045833
- Testing
- SYN-020 Delayed Release Capsule
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Theriva Biologics, Inc.
Acute Radiation Enteritis
Improvement Effect of Dexamethasone Enema for Acute Radiation-induced Rectal Injury
Research Objective and Principle: Through a randomized controlled study, evaluate the effectiveness of dexamethasone in improving radiation-induced rectal injury in rectal cancer patients undergoing pelvic radiotherapy, thereby…
- Trial name
- NCT07548736
- Testing
- Experimental Group (dexamethasone enema), Control group (dexamethasone enema)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Prostate Cancer, Radiotherapy Side Effect
PROstate CAncer Radiotherapy - Bowel Quality of Life (PROCAR-BQ)
This is a prospective pilot study to evaluate the mean increase of bowel symptoms after pelvic radiotherapy (RT) in prostate cancer (PCa) patient using the validated \& newly translated EORTC-QLQ PRT20 module.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Bowel Dysfunction, Quality of Life
- Trial name
- PROCAR-BQ (NCT05880446)
- Testing
- Bowel symptoms & QoL assessment
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Jules Bordet Institute
Radiotherapy Induced Diarrhea, Acute Radiation Enteritis
Efficacy and Safety of Adjunctive Use of Rifaximin In Preventing Radiotherapy-induced Diarrhea in Cancer Patients
Preclinical data indicate that rifaximin could be repurposed as a novel strategy for preventing and reducing the severity of gastrointestinal damage, particularly diarrhea, that results from pelvic irradiation.
- Conditions
- Radiotherapy Induced Diarrhea, Acute Radiation Enteritis, Prostate Cancer, Cervical Adenocarcinoma
- Trial name
- NCT06783153
- Testing
- Rifaximin 550 MG, Standard Care Chemoradiation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Acute Radiation Enteritis
Preventive Efficacy of Bergmann Enema for Acute Radiation-induced Rectal Injury in Rectal Cancer Patients Undergoing Short-course Radiotherapy
Research Objective and Principle: To evaluate the effectiveness of Bergmann enema in preventing acute radiation-induced rectal injury in patients with rectal cancer, thereby providing a basis for treatment options for potential…
- Trial name
- NCT07302126
- Testing
- Bergmann enema
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease, Peritoneal Carcinomatosis With Intestinal Occlusion
CAre of Patients With PArenteral Nutrition At Home
This research aims to give an overview of a number of aspects related to the quality of care for adult patients on home parenteral nutrition.
- Conditions
- Crohn's Disease, Peritoneal Carcinomatosis With Intestinal Occlusion, Radiation Enteritis, Chronic Diarrhea
- Trial name
- CAPANAH (NCT01545063)
- Where
- 13 sites in Belgium
- Volunteers
- 39 people
- Sponsor
- KU Leuven
Radiation Enteritis
A Study for Assessing the Efficacy and Safety of BH4 in Radiation Enteritis
This present study envisaged a single-center, prospective, open-label, placebo and randomized controlled phase II clinical study to assess the efficacy and Safety of Tetrahydrobiopterin in Treating Radiation Enteritis in…
- Trial name
- NCT05138887
- Testing
- Tetrahydrobiopterin
- Where
- China
- Volunteers
- 366 people
- Sponsor
- West China Second University Hospital
Diarrhea, Enteritis
Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -
Therapy-associated diarrhea during radiation therapy of small pelvis (including enteritis as a result of radiation therapy and enteritis as a result of radiation- and chemotherapy) is a common problem in multimodal cancer…
- Conditions
- Diarrhea, Enteritis, Cancer
- Trial name
- Loop (NCT00444093)
- Testing
- Opii normata treatment, Loperamid Treatment
- Volunteers
- 1 people
- Sponsor
- Philipps University Marburg
Radiation Enteritis
Therapy of Radiation Enteritis With Glutamine
Objective: To evaluate the effects of perioperative glutamine supplemented total parenteral nutrition support on nutritional status, immunologic function and intestinal permeability of patients with chronic radiation intestinal…
- Trial name
- NCT01758783
- Testing
- Glutamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing University School of Medicine
Radiation Enteritis
Plasma GLP-2 Dynamics and Acute Radiation Enteritis After Abdominopelvic Radiotherapy
This prospective observational study will enroll 50 adults who are scheduled to receive radiotherapy to the abdomen or pelvis. The study will not assign any additional treatment or change routine clinical care.
- Trial name
- NCT07759258
- Testing
- Abdominopelvic Radiotherapy
- Volunteers
- 50 people
- Sponsor
- Wang Xinying