Clinical trials: Radiation Tolerance
Radiotherapy, Brain Metastases
Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases
Stereotactic radiation therapy is an important and common method of treating brain metastases in patients with malignant disease.
- Conditions
- Radiotherapy, Brain Metastases, Sensitivity, Radionecrosis
- Trial name
- NCT04700748
- Testing
- Brain metastases radiation
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University Hospital
Sarcoma
Preoperative IMRT for Soft Tissue Sarcoma of the Extremities and Trunk: Low Rate of Wound Complications
Postoperative wound healing complications following preoperative radiotherapy represent a severe problem in the treatment of malignant soft tissue tumors, and are reported to be 34% and more.
- Trial name
- NCT02785692
- Testing
- Radiation
- Where
- 2 sites in Switzerland
- Volunteers
- 67 people
- Sponsor
- Balgrist University Hospital
Metastatic Neuroendocrine Tumour
Evaluation of the Quality of Life and Tolerance of Patients Treated With Vectorized Internal Radiotherapy (RIV) for a Neuro Endocrine Tumor (NET) in the Auvergne-Rhône-Alpes Region.
The study consists of having participants complete quality of life questionnaires (PROMs) at the time of the cures +/- one week and in the middle of the intercure time +/- one week.
- Trial name
- AURA-RIV-TNE (NCT06043193)
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Ultraviolet Rays, Immunosuppression
Effect of RANKL Inhibition on UV-induced Immunosuppression
Ultraviolet (UV) light is part of normal sunlight and has many effects on human skin and health. One of the harmful effects of long-term UV light exposure is that it can cause skin cancer.
- Conditions
- Ultraviolet Rays, Immunosuppression, Hypersensitivity, Delayed, Immune Tolerance/Drug Effects
- Trial name
- NCT01978483
- Testing
- Denosumab, UVB exposure, Diphenylcyclopropenone
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
Stage III NSCLC
Adjuvant Chemotherapy +/- Cemiplimab and Sequential Hypofractionated Radiotherapy in Unfit or Elderly Patients With Stage III Lung Cancer
The use of neoadjuvant immuno-chemotherapy could improve survival outcomes of patients eligible for sequential radio-chemotherapy comparing to the benefit already obtained with maintenance immunotherapy.
- Trial name
- SPORADIC (NCT06656598)
- Testing
- Carboplatin, Paclitaxel, Cemiplimab
- Where
- 25 sites in France
- Volunteers
- 152 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Radiation Tolerance, Breast Neoplasms
Prediction of Individual Radiosensitivity During Radiotherapy for Breast Cancer Patients
Non-randomized clinical cohort study investigating if single nucleotide polymorphism (SNP) or inflammatory markers can predict radiosensitivity in breast cancer patients receiving radiotherapy.
- Trial name
- SENS (NCT05566613)
- Testing
- Blood sample
- Where
- Sweden
- Volunteers
- 550 people
- Sponsor
- Karolinska University Hospital
Biomarker, Radiosensitivity
A Bidirectional Cohort Study of COMMD10 Expression in Tumor Tissues for Predicting Radiosensitivity
Radiotherapy is one of the main treatments for malignant tumors, and according to authoritative estimates, about 70% of patients with malignant tumors should receive radiotherapy.
- Trial name
- NCT06165224
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Squamous Cell Lung Cancer
A Study of Pemetrexed Plus Cisplatin With Concurrent Radiation Therapy Followed by Docetaxel Consolidation in Patients With Inoperable Squamous Cell Lung Cancer
To evaluate the efficacy and toxicity of patients with inoperable squamous cell lung cancer treated with pemetrexed plus cisplatin with concurrent radiation therapy followed by docetaxel consolidation.
- Trial name
- NCT02787473
- Testing
- pemetrexed, cisplatin, thoracic radiation therapy
- Where
- China
- Volunteers
- 54 people
- Sponsor
- First People's Hospital of Hangzhou
Liver Transplantation, Immune Tolerance
Immune Tolerance Induction After Liver Transplantation
This clinical trial is being conducted to help liver transplant recipients safely discontinue toxic immunosuppressive drugs years after surgery.
- Conditions
- Liver Transplantation, Immune Tolerance, Immune Tolerance/Drug Effects, Graft Survival
- Trial name
- iTILT (NCT07269041)
- Testing
- Donor Hematopoietic Stem and Progenitor Cell Infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Los Angeles
Breast Cancer
Clinical Database of Safe Personalized Adjuvant Breast Radiotherapy Based on Individual Radiosensitivity
Severe but also moderate toxicities after curative-intent radiotherapy (RT), such as a poor cosmetic outcome following breast cancer can have a negative impact on quality of life and a marked effect on subsequent psychological…
- Trial name
- SAHARA-01 (NCT04282122)
- Testing
- Radiotherapy
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Nasopharyngeal Cancer, Prostate Cancer
Discovery of Biomarkers for Intrinsic Radiation Sensitivity in Cancer Patients
Patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study.
- Conditions
- Nasopharyngeal Cancer, Prostate Cancer, Other Cancer
- Trial name
- NCT04340024
- Where
- Singapore
- Volunteers
- 5,000 people
- Sponsor
- National Cancer Centre, Singapore
Esophageal Cancer
Concurrent Chemoradiotherapy Containing Paclitaxel&Cisplatin With/Without Tarceva in Locally Advanced Esophageal Cancer
This study is multi-center randomized phase III one to evaluate the difference in local-control and survival rate between patients receiving concurrent chemoradiotherapy combined Tarceva or not.
- Trial name
- NCT00686114
- Testing
- Paclitaxel, Cisplatin, Tarceva
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Wenzhou Medical University
Lung Cancer
Evaluation of the NOVATECH ® LUCIOLA TM EB Fiducial Marker During Radiotherapy Sessions in Lung Cancer Patients
Following CE certification, this Post Market Clinical Follow-up investigates the performance and safety of using the new fiducial marker, NOVATECH® LUCIOLA™ EB, in the lung airways to monitor in real-time tumor location during…
- Trial name
- LUCIOLA (NCT05068973)
- Testing
- NOVATECH® LUCIOLA™ EB - (Fiducial Marker)
- Where
- 5 sites in France
- Volunteers
- 35 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Colorectal Cancer, Colorectal Carcinoma
Nelfinavir, a Phase I/Phase II Rectal Cancer Study
The aim is to study safety and activity of nelfinavir , added to standard chemoradiotherapy in patients with locally advanced rectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Tumors, Neoplasms, Colorectal
- Trial name
- Nelfinavir (NCT00704600)
- Testing
- nelfinavir
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht Radiation Oncology
Radiation Tolerance, Skin Aging
Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects
Photomodulation is a process which manipulates or regulates cell activity using light sources without thermal effect. Different studies have investigated the use of non-thermal low dose light emitting diode (LED) array for…
- Conditions
- Radiation Tolerance, Skin Aging, Rhytids
- Trial name
- NCT00818311
- Testing
- LED GentleWaves®
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Cancer
Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for Cancer
RATIONALE: Identifying genes that increase a person's susceptibility to second cancers may help the study of cancer treatment. PURPOSE: This study is looking at genetic susceptibility and risk of second cancers in patients who…
- Trial name
- NCT00949052
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Neoplasms
Involvement of the Immune System in Intrinsic Radiosensitivity
Radiotherapy is one of the major treatments for cancer. It may be indicated in more than two-thirds of patients, regardless of cancer location or disease stage.
- Trial name
- TRANSPROUST (NCT06826066)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Cancer, Precancerous Condition
Cidofovir in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Who Are Receiving Chemotherapy and Radiation Therapy
RATIONALE: Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00811408
- Testing
- carboplatin, cidofovir, protein expression analysis
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
End Stage Kidney Disease, Immunological Tolerance
Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function…
- Conditions
- End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- NCT05525507
- Testing
- Conditioning and Stem cell infusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles