Clinical trials: Radiotherapy, Intensity-Modulated
Hypofractionated Radiotherapy, Intensity-modulated Radiotherapy
Adjuvant Moderately Hypofractionated Intensity-modulated Radiotherapy for Cervical Cancer
To investigate the safety and efficacy of moderately hypofractionated intensity-modulated radiotherapy in the treatment of postoperative cervical cancer
- Conditions
- Hypofractionated Radiotherapy, Intensity-modulated Radiotherapy, Cervical Cancers
- Trial name
- NCT07684508
- Testing
- Postoperative Radiotherapy
- Where
- 2 sites in China
- Volunteers
- 154 people
- Sponsor
- Manni Huang
Sarcoma,Soft Tissue, Extremity
Preoperative IMRT With Anlotinib and Penpulimab for Localized Sarcoma （SPARE-01）
To investigate the safety and efficacy of preoperative IMRT and concurrent Anlotinib Hydrochloride for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination…
- Conditions
- Sarcoma,Soft Tissue, Extremity, Trunk, Anlotinib
- Trial name
- SPARE-01 (NCT05167994)
- Testing
- Anlotinib hydrochloride
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Lung Adenocarcinoma, Brain Metastases
Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases
This is a phase 3, randomized, controlled clinical trial comparing two brain-directed treatment strategies for adult patients with extensive brain metastases from lung adenocarcinoma.
- Conditions
- Lung Adenocarcinoma, Brain Metastases, Radiotherapy, Intensity-Modulated, Bevacizumab
- Trial name
- NCT07481786
- Testing
- FSRT, HA-WBRT-SIB, Bevacizumab
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-sen University
Palliative Radiotherapy, Radiotherapy, Intensity-Modulated
Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single
One third of patients treated in the radiation oncology departments are treated with palliative intent. These patients can be unwell due to their advanced disease and suffering from pain and other symptoms related to metastases.
- Trial name
- ASPIRE single (NCT04658537)
- Testing
- Radiation Therapy
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal North Shore Hospital
Nasopharyngeal Cancinoma (NPC), Intensity-modulated Radiotherapy
IMRT Alone for Stage IB Nasopharyngeal Carcinoma Without High-Risk Features
This observational study aims to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone in patients with stage IB nasopharyngeal carcinoma (NPC) without high-risk features.
- Conditions
- Nasopharyngeal Cancinoma (NPC), Intensity-modulated Radiotherapy, Stage IB
- Trial name
- NCT07376603
- Testing
- IMRT along
- Where
- China
- Volunteers
- 169 people
- Sponsor
- Qiaojuan Guo
Sarcoma,Soft Tissue, Extremity
Preoperative IMRT With Concurrent Apatinib for Localised Extremity or Trunk Sarcoma （SPARE-02）
To investigate the safety and efficacy of preoperative IMRT and concurrent Apatinib for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination treatment; To…
- Conditions
- Sarcoma,Soft Tissue, Extremity, Trunk, Intensity-modulated Radiotherapy
- Trial name
- SPARE-02 (NCT05235100)
- Testing
- Apatinib Mesylate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Cancer Metastatic, Chemotherapy
Oral Chemotherapy, Targeted Therapy and Immunotherapy With/Without Radiotherapy as 3rd- or Later-line Therapy for Advanced MSS/pMMR Colorectal Cancer
The current phase 2, double cohort clinical trial was designed to determine the effectiveness of Trifluridine and Tipiracil Hydrochloride Tablets, Bevacizumab and Sintilimab with/without involved lesions irradiation as 3rd- or…
- Conditions
- Colorectal Cancer Metastatic, Chemotherapy, Targeted Therapy, Immunotherapy
- Trial name
- NCT06764680
- Testing
- Trifluorouracil tepidopyrimidine, Bevacizumab, Sindilizumab
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Immunotherapy, Intensity Modulated Radiation Therapy
Omitting Clinical Target Volume in Radical Treatment of Unresectable Stage III Non-small Cell Lung Cancer
Simultaneous radiotherapy followed by adjuvant immunotherapy is the standard treatment modality of unresectable stage III NSCLC.
- Conditions
- Immunotherapy, Intensity Modulated Radiation Therapy, Radiotherapy, NSCLC
- Trial name
- NCT05909137
- Testing
- IMRT+adjuvant immunotherapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Breast Cancer, Proton Therapy
Safety and Efficacy of IMPT or IMRT for Breast Cancer
The purpose of this trial is to compare the toxicities and efficacy of intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT) for breast cancer patients indicated for radiotherapy including…
- Conditions
- Breast Cancer, Proton Therapy, Intensity Modulated Radiation Therapy, Efficacy and Safety
- Trial name
- SEPPT-BC (NCT06826885)
- Testing
- Postoperative radiotherapy, Preoperative Radiotherapy, Definitive Radiotherapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Cervix Cancer, Radiotherapy, Adjuvant
Postoperative Hypofractionated Intensity-modulated Radiation Therapy with Concurrent Chemotherapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by concurrent chemotherapy with hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16…
- Conditions
- Cervix Cancer, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Hypofractionated Dose
- Trial name
- NCT03239613
- Testing
- POHIM-CCRT
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cervix Cancer, Radiotherapy, Adjuvant
Postoperative Hypofractionated Intensity-modulated Radiation Therapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16 fractions, once a day) after…
- Conditions
- Cervix Cancer, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Hypofractionated Dose
- Trial name
- NCT03239626
- Testing
- POHIM-RT
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Nasopharyngeal Carcinoma, Intensity Modulated Radiotherapy
Endoscopic Surgery vs. Intensity Modulated Radiotherapy for Stage I Nasopharyngeal Carcinoma.
The goal of this clinical trial is to compare the survival and adverse reactions differences between endoscopic surgery and intensity modulated radiotherapy for patients with newly diagnosed stage Ⅰ nasopharyngeal carcinoma…
- Conditions
- Nasopharyngeal Carcinoma, Intensity Modulated Radiotherapy, Surgery
- Trial name
- NCT06533267
- Testing
- Endoscopic nasopharyngectomy followed close follow-up, Intensity-modulated Radiotherapy
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma, Intensity-Modulated Radiotherapy
Reducing High Risk Primary Tumor Clinical Target Volumes (CTVp1) in Non-metastatic Nasopharyngeal Carcinoma
To evaluate the long-term local control, survival rate, acute and late radiation related toxicities, quality of life after reducing high risk primary tumor clinical target volumes (CTVp1) in non-metastatic nasopharyngeal…
- Trial name
- CTVp1-NPC (NCT05994170)
- Testing
- Reduction CTVp1, Non-reduction CTVp1
- Where
- China
- Volunteers
- 454 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Nasal Cavity Cancer, Paranasal Sinus Cancer
Camrelizumab Plus Chemoradiotherapy for Patients With Locoregional Cancer of Nasal Cavity and Paranasal Sinuses
Patients with locoregional cancer of nasal cavity and paranasal sinuses are candidate for this study. All the eligible patients receive three cycles of induction chemotherapy (docetaxel 60mg/m2+cisplatin…
- Conditions
- Nasal Cavity Cancer, Paranasal Sinus Cancer, Camrelizumab, Induction Chemotherapy
- Trial name
- NCT05114707
- Testing
- camrelizumab
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Glioma, Radiotherapy, Intensity-Modulated
Treatment of High-grade Gliomas Using Hypofractionated Radiation Therapy -a Phase I Clinical Trial
Postoperative conventional radiation at 60 Gy/30f is currently still considered the standard radiotherapy mode for high-grade gliomas; however, the efficacy is still unsatisfactory.
- Conditions
- Glioma, Radiotherapy, Intensity-Modulated, Maximum Tolerated Dose
- Trial name
- NCT03082846
- Testing
- hypofractionated radiation, Temozolomide chemotherapy
- Volunteers
- 16 people
- Sponsor
- Xue Xiaoying
Stomach Neoplasms, Chemoradiotherapy, Adjuvant
A Phase II Study of Postoperative S-1-Based Chemoradiotherapy in Gastric Cancer
The aim of this phase II trial was to evaluate the feasibility, efficacy and tolerability of intensity-modulated radiotherapy combined with S-1 based chemotherapy in patients with pathologically positive lymph node after…
- Conditions
- Stomach Neoplasms, Chemoradiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated
- Trial name
- NCT02296658
- Testing
- intensity-modulated radiotherapy, S-1
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Medical Sciences
Nasopharyngeal Cancers, Intensity Modulated Radiotherapy With Chemotherapy
Parotid-sparing IMRT for Nasopharyngeal Cancer
In the treatment of nasopharyngeal cancers, to determine the incidence of high grade (≥G2) subjective xerostomia at 1 year.
- Trial name
- NCT02149641
- Testing
- Intensity modulated radiotherapy with chemotherapy
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Royal Marsden NHS Foundation Trust