Clinical trials: Randomised Controlled Trial
Total Knee Replacement
Effects of Combined Topical and Systemic Steroid Administrations on Better Early Postoperative Pain Management in Total Knee Arthroplasty
With the aging of population, osteoarthritis of knees and hips has become major orthopaedic problems in Hong Kong. Osteoarthritis of knees and hips is associated with significant pain problems and functional disability.
- Trial name
- NCT03901768
- Testing
- Dexamethasone, Triamcinolone
- Where
- Hong Kong
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Knee Osteoarthritis
ESCAPE-pain Programme in Malaysia
The overall aim of this study is to develop an evidence based exercise programme for the management of knee osteoarthritis which is feasible and acceptable to patients and healthcare professionals in Malaysia.
- Trial name
- NCT03379623
- Testing
- ESCAPE-pain Programme
- Where
- 2 sites in Malaysia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Kamil Che Hasan
Oral Health
Interactive Video- and Game-Based Oral Health Education for 11-Year-Old Schoolchildren
The goal of this cluster randomised controlled trial is to learn if an interactive video- and game-based oral health education intervention helps improve oral health outcomes among 11-year-old schoolchildren in Pulau Pinang…
- Trial name
- NCT07097324
- Testing
- Video- and Game-Based Oral Health Education, Conventional Oral Health Talk
- Where
- Malaysia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Obesity
Study of Efficacy of a Probiotic and Postbiotic in Overweight and Obese Individuals
The study's main objective is to investigate the effect of a probiotic (live bacteria), postbiotic (heat-treated bacteria) on obesity parameters.
- Trial name
- Obelix (NCT05440630)
- Testing
- Probiotics, Postbiotic
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Mild Cognitive Impairment
Exploratory Trial in Healthy Adults With Mild Cognitive Impairment,16-week Intervention With Mitocholine™
To evaluate the effect of 16-weeks consumption of Mitocholine on Executive Function and Homocysteine levels in a population experiencing Mild Cognitive Impairment.
- Trial name
- NCT05690724
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mitocholine Ltd
Post-traumatic Stress Disorder, Depression
Randomized Control Trial of Group Intervention With Former War-affected Boys in the Democratic Republic of Congo
The purpose of this study is to evaluate, in a randomised control trial (RCT), the effectiveness of group-based, trauma-focused Cognitive Behaviour Therapy (TF-CBT) in reducing psychological distress in former child soldiers and…
- Conditions
- Post-traumatic Stress Disorder, Depression, Conduct Disorder
- Trial name
- NCT01494831
- Testing
- TF-CBT
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Migraine
RCT of IV Dexamethasone to Prevent Relapse in the Treatment of Migraine in a Paediatric ED
Background: Headaches is one of the most common complaints of children in the ED and the treatment of pediatric migraine is largely based on extrapolation data from adult studies, limited pediatric trials, clinical experience and…
- Trial name
- NCT02903680
- Testing
- Dexamethasone group
- Where
- Canada
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
HPV Infection, HPV-Related Carcinoma
To Evaluate the Safety and Immunogenicity of 15-valent HPV Recombinant Vaccine in Chinese People Aged 9-45 Years
To evaluate the safety and Immunogenicity of 15-valent HPV vaccine in 9-45year-old participants.
- Conditions
- HPV Infection, HPV-Related Carcinoma, HPV-Related Intraepithelial Neoplasia, Genital Wart
- Trial name
- NCT06756269
- Testing
- Medium dose for 15-HPV vaccine, High dose for 15-HPV vaccine, 9-HPV vaccine
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Mental Health Mood Disturbance Occupational Stress
Monthly Mood Improvement After Workplace Mindfulness
This randomized controlled pilot trial investigates the effects of a brief workplace mindfulness-based intervention (MBI) on mood among full-time employees in Japan.
- Trial name
- MBI-WORK (NCT07029022)
- Testing
- Mindfulness-Based Intervention (MBI)
- Where
- Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Shinyu Kise
Insomnia, ADHD
CBT-I in Adolescents With ADHD
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity, affecting individuals across the lifespan.
- Trial name
- NCT07209969
- Testing
- CBT-I group
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Acute Respiratory Tract Infections
Optimisation of Antibiotic Prescription in Acute Noncomplicated Respiratory Tract Infections in Children (OptimAP Study)
Background: High-volume antibiotic prescribing in primary care is a major driver of antibiotic resistance. Education of physicians and patients can lower prescribing levels, but it frequently relies on highly trained staff.
- Trial name
- OptimAP (NCT05166369)
- Testing
- Communication skills training, Mobile phone application on RTI
- Where
- 4 sites in Spain
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Fistula in Ano, Rectal Fistula
Laser Assisted Treatment of Fistula In Ano
Randomised Controlled Trial comparing Laser assisted closure of transsphincteric fistula to the rectal advancement flap.
- Trial name
- LATFIA (NCT05390151)
- Testing
- Laser treatment of anal fistula, RAF
- Where
- 5 sites in Belgium
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Healthy
An Euglycemic Clamp Trial to Evaluate Pharmacokinetics of Single Doses of BioChaperone Insulin Lispro in Healthy Japanese Subjects
This is a double-blind, randomised, three period crossover phase 1 trial using automated 8-hour euglycemic clamps in healthy Japanese subjects.
- Trial name
- NCT02660502
- Testing
- Biochaperone insulin lispro 0.1 U/kg, Biochaperone insulin lispro 0.2 U/kg, Biochaperone insulin lispro 0.4 U/kg
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Adocia
Overweight and Obesity
The Effect of Alginate Supplementation on Weight Management
This project will assess the effect of the alginate (in a capsules) on the weight of generally healthy volunteers over a 12 week period.
- Trial name
- NCT04589273
- Testing
- Alginate
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Prostate Cancer, Creative Arts Therapy
Creative Arts Therapy on Body Image, Self-esteem, Anxiety and Depression in Post-Treatment Prostate Cancer Patients
The goal of this clinical study is to assess the feasibility of implementing a creative arts therapy intervention of drawing and painting in Hong Kong prostate cancer patients and preliminarily examine the effects of this…
- Trial name
- NCT07015866
- Testing
- Guided therapy group, Creative arts therapy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Not Determined
First-In-Human (FIH) Trial Evaluating the Safety and Tolerability of Single and Multiple Ascending Oral Doses of IRL757 in Healthy Volunteers
This is a Phase 1, First-In-Human study evaluating the safety and tolerability of single and multiple ascending oral doses of IRL757 in healthy volunteers.
- Trial name
- NCT06493045
- Testing
- IRL757
- Where
- Sweden
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Integrative Research Laboratories AB
Staff Support
A Pilot RCT Examining the Effectiveness of CMT for Healthcare Staff
The COVID-19 pandemic has highlighted the critical need for evidence-based interventions to support the psychological wellbeing of healthcare staff, particularly within Occupational Health settings.
- Trial name
- NCT07411183
- Testing
- Compassionate Mind Training, Staffcare Counselling
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Drug Safety
Data-driven Quality Improvement in Primary Care - Trial
A cluster randomised controlled trial to test the effectiveness of an informatics tool, educational and financial incentives to reduce high risk prescribing of non-steroidal anti-inflammatory drugs and anti-platelet agents.
- Trial name
- DQIP (NCT01425502)
- Testing
- DQIP Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Dementia, Accidental Falls
The TACIT Trial: TAi ChI for People With demenTia
This is a three-centre parallel group randomised controlled trial with an embedded process evaluation and intervention pilot phase (details not provided in this summary).
- Trial name
- TACIT (NCT02864056)
- Testing
- Tai Chi
- Where
- 3 sites in United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Healthy Adult Female Participants, Health Behavior
The Effect of Water Conservation Education on Women's Water Use Behaviours
This research will be conducted to evaluate the effects of the Health Belief Model based water saving training prepared for women on the size of the water footprint, water consumption habits and water consumption amount.
- Conditions
- Healthy Adult Female Participants, Health Behavior, Climate Change, Water Use
- Trial name
- NCT06824246
- Testing
- Water conservation education, Monitoring water bill
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Selcuk University