Clinical trials: Randomized, open to volunteers
Liver Disease (Alcoholic or Not), Transplantation
In-situ vs Ex-situ Liver Preservation
The goal of this Randomized Controlled Trial is to learn what machine preservation method is most clinically effective for liver transplantation (LTx) after donation after circulatory death (DCD).
- Trial name
- INSPIRE-NL (NCT07899853)
- Testing
- In-situ perfusion: aNRP, Ex-situ perfusion: DHOPE/DHOPE-COR-NMP
- Where
- 3 sites in Netherlands
- Volunteers
- 752 people
- Sponsor
- Leiden University Medical Center
Chronic Obstructive Pulmonary Disease
Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR)
Several studies have demonstrated the benefits of the LAMA (Long-Acting Muscarinic Antagonists) + LABA (Long-Acting Beta-Agonists) + IC (inhaled corticosteroids) combination in the treatment of chronic obstructive pulmonary…
- Trial name
- TRIPLAR (NCT06234345)
- Testing
- Fluticasone 250mcg/Formoterol 12mcg/Glycopyrronium 25mcg, Comparator - Trimbow®
- Where
- Brazil
- Volunteers
- 1,252 people
- Sponsor
- Eurofarma Laboratorios S.A.
Carious Primary Molars Indicated for Pulpectomy
Evaluation of Zinc Oxide Eugenol and Iodoform-Calcium Hydroxide as Filling Materials in Primary Molar Root Canals Prepared by Rotary and Manual Files
This randomized controlled clinical trial aims to compare the clinical and radiographic outcomes of Zinc Oxide Eugenol (ZOE) and Iodoform-Calcium Hydroxide (Metapex) as root canal filling materials in primary molars prepared…
- Trial name
- NCT07395401
- Testing
- Manual Instrumentation, Iodoform-Calcium Hydroxide (Metapex), Rotary Instrumentation
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- October University for Modern Sciences and Arts
Intravenous Cannulation
The Effect of Near-infrared Spectroscopy on the Success of Peripheral Venous Access
The goal of this clinical trial is to learn if using near-infrared imaging in pediatric vein cannulation is leading to higher success rate.
- Trial name
- PEDVEIN (NCT07279701)
- Testing
- Use of near-infrared imaging by VeinViewer Flex of periferal veins
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Brno University Hospital
Cervix Cancer, HIV Infections
Clinic vs Clinic+Community Outreach HPV Self-Collection to Increase Cervical Screening in Women With HIV
This Clinical Trials Network for Human Immunodeficiency Virus (HIV)-Associated Cervical Cancer Screening and Treatment Optimization (CASCADE) C3001-A trial aims to assess how the introduction of a…
- Conditions
- Cervix Cancer, HIV Infections, HPV Infection
- Trial name
- CASCADE3001A (NCT07428330)
- Testing
- Model 1- Screening in Clinic Only, Model 2 - Screening in Clinic and Community
- Where
- Uganda
- Volunteers
- 7,597 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
PARKINSON DISEASE (Disorder)
Feasibility of a Community-Based Multimodal Exercise Programme in Parkinson's Disease
This study aims to evaluate the feasibility and preliminary effectiveness of a multimodal, group-based but individualised therapeutic exercise programme for people with Parkinson's disease delivered within a real-world…
- Trial name
- NCT07618728
- Testing
- Exercise Group
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Universidad Rey Juan Carlos
Gastric Cancer
Financial Incentives and Motivational Intervention to Improve Gastric Cancer Screening in China
Gastric cancer, also known as stomach cancer, is a serious disease that affects the stomach. It's one of the most common types of cancer, and sadly, many people die from it each year.
- Trial name
- NCT06384300
- Testing
- Financial Incentives, Motivational Intervention, Mixed Intervention
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Multiple Myeloma
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to evaluate how well JNJ-79635322 works when compared with an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody.
- Trial name
- TRIlogy-4 (NCT07258511)
- Testing
- JNJ-79635322, Teclistamab
- Where
- 150 sites in United States, Australia and 13 more
- Volunteers
- 400 people
- Sponsor
- Janssen Research & Development, LLC
Pneumonia, Ventilator-Associated Healthcare-associated Pneumonia Respiration, Artificial
Combined Strategy Using Automated Subglottic Secretion Drainage and Continuous Cuff Pressure Monitoring to Prevent Microaspiration: a Multicenter Randomized Controlled Trial.
This trial will study the impact of a combined strategy to prevent microaspiration of oropharyngeal secretions or gastric content using automated subglottic secretion drainage and/or continuous cuff pressure monitoring.
- Trial name
- cosmic (NCT07555236)
- Testing
- Combined strategy, Automated subglottic secretion drainage, Automated continuous cuff pressure monitoring
- Volunteers
- 800 people
- Sponsor
- University Hospital, Lille
Newly Diagnosed Acute Myeloid Leukemia (AML), Elderly Patients
Venetoclax-Azacitidine in Combination With Chidamide and CAG in Fit Older Patients With Acute Myeloid Leukaemia
This study is a multicenter, prospective, randomized, controlled clinical trial, observing the efficacy and safety of the CACAG+Venetoclax regimen (Chidamide + Azacitidine + Aclarubicin + Cytarabine + Recombinant Human…
- Trial name
- NCT07514936
- Testing
- the standard "3+7" regimen, Azacytidine; Cytarabine; Aclacinomycin; Chidamide; Venetoclax; Granulocyte
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Gestational Diabetes Mellitus in Pregnancy, Hypertension ,Pregnancy
Impact of Behavioural Modification Working Toolkit Among Women With Gestational Diabetes Mellitus and Hypertension
This trial aims to evaluate the effectiveness of a Behavioral Modification Working (BMW) Toolkit in improving glycemic control and blood pressure among pregnant women diagnosed with both GDM and PIH.
- Trial name
- NCT07551011
- Testing
- Behavioral Modification Working (BMW) Toolkit, Routine Antenatal Care
- Where
- 2 sites in Pakistan
- Volunteers
- 220 people
- Sponsor
- University of the Punjab
Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Short-term Perioperative Daidzein Intervention on Liver Histopathology in Patients With MASLD
This clinical trial aims to learn whether daidzein can improve liver tissue changes in adults with metabolic dysfunction-associated steatotic liver disease, also called MASLD.
- Trial name
- DAIMAS (NCT07623044)
- Testing
- Daidzein
- Volunteers
- 44 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Chemotherapy Induced Nausea and Vomiting
Olanzapine Versus Placebo for Moderately Emetogenic Chemotherapy
A study comparing efficacy of olanzapine versus placebo to prevent nausea and vomiting from moderate emetic risk chemotherapy
- Trial name
- NCT06850454
- Testing
- olanzapine
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Mahidol University
Hypertension (HTN)
Finerenone and Empagliflozin Combination in Obesity With Hypertension: A 12-Week Prospective, Parallel-design, Double-blind, Randomized, Placebo-controlled Trial
The EFFORT Study (Empagliflozin and Finerenone Combination in Obesity with Hypertension) is a 12-week, randomized, double-blind, placebo-controlled trial that aims to test whether combining empagliflozin (10 mg/day) with…
- Trial name
- NCT07678151
- Testing
- Empagliflozin and Finerenone
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Heart Health Research Center
Gall Bladder Cancer
Radiation Therapy in Unresectable Gall Bladder Cancer
The goal of this clinical trial is to compare two treatment regimes, namely, systemic therapy (chemotherapy and/or immunotherapy) alone vs.
- Trial name
- RUGB (NCT06214572)
- Testing
- Systemic therapy (Gemcitabine plus Cisplatin), RT, Systemic therapy (Gemcitabine plus oxaliplatin)
- Where
- India
- Volunteers
- 249 people
- Sponsor
- Tata Memorial Centre
Progressive Collapsing Foot Deformity
Three Foot Orthosis Interventions for Progressive Collapsing Foot Deformity
Background Progressive collapsing foot deformity (PCFD) is a painful musculoskeletal disorder leading to a progressively developing flat foot, which affects mobility and function and negatively impairs quality of life.
- Trial name
- NCT07756372
- Testing
- Customized foot orthoses, Exercise, Podiatric Education
- Where
- 2 sites in Canada
- Volunteers
- 198 people
- Sponsor
- Université du Québec à Trois-Rivières
Dentin Hypersensitivity
Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)
The aim of the study to compare the clinical effectiveness of Episodic use of Bioactive Silica Based versus continuous use of fluoride based desensitizing toothpastes in management of dentin hypersensitivity (DH) of adult…
- Trial name
- NCT07120139
- Testing
- episodic use of the desensitizing toothpaste, continuous use of the conventional desensitizing toothpaste
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
Endometrial Cancer, Pathology
Adjuvant Radiotherapy in Patients With Early Endometrial Cancer
To compare the effect of vaginal brachytherapy as adjuvant treatment after operation when compared to pelvic external beam radiotherapy in patients with early endometrial cancer based on moderate risk molecules classification.
- Conditions
- Endometrial Cancer, Pathology, Radiotherapy
- Trial name
- NCT04956601
- Testing
- vaginal brachytherapy/pelvic external beam radiotherapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Peking University Third Hospital
Rectal Cancer, Advanced Cancer
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal…
- Trial name
- NORAD01 (NCT03875781)
- Testing
- Chemotherapy, Radiochemotherapy
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease
Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease
The objective of the SMART trial is to compare a combination therapy using azathioprine and subcutaneous infliximab versus ileocecal resection in patients with symptomatic small bowel Crohn's disease.
- Trial name
- SMART (NCT05584228)
- Testing
- Azathioprine + infliximab, Intestinal resection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
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