Clinical trials: Randomized Clinical Trial
Temporomandibular Joint Disorders
The Effect of Piroxicam Addition During Arthrocentesis on Mouth Opening and Postoperative Pain
TMDs is an ancient condition discovered thousands of years ago. Historians state that the ancient Egyptians were the first who managed TMDs. They manually treated joint dislocation by away similar to ours nowadays.
- Trial name
- NCT06508203
- Testing
- arthrocentesis with lactate ringer only, arthrocentesis with lactate ringer followed by injection with piroxicam 2 ml (40mg)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gingivitis
Flossing With Chlorhexidine
To determine if flossing with a dental floss presoaked in chlorhexidine, an anti-microbial mouth wash, would improve the clinical signs of gingivitis, an inflammation of the gums characterized by red, swollen, bleeding gums.
- Trial name
- NCT00471783
- Testing
- Chlorhexidine is the generic name of the mouthwash, Peridex is the brand name.
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
COVID-19
Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine
Rationale: Covid-19 spreads rapidly throughout the world. A large epidemic in the Netherlands would seriously challenge the available hospital capacity, and this would be augmented by absenteeism of healthcare workers (HCW).
- Trial name
- BCG-CORONA (NCT04328441)
- Testing
- BCG Vaccine
- Where
- 9 sites in Netherlands
- Volunteers
- 1,511 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Mental Health Wellness
Effectiveness of Four Deconstructive Meditative Practices on Well-being and Self-deconstruction
The efficacy of interventions based on mindfulness and compassion has been demonstrated in both clinical and general population, and in different social contexts.
- Trial name
- NCT05317754
- Testing
- Mindful breathing, Prostrations, according to Tibetan Buddhist tradition, The Koan Mu, according to Zen Buddhist tradition
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Peridontitis
Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis
The main objective of the current study is to clinically and biochemically evaluate the effectiveness of epigallocatechin-3-gallate-loaded chitosan nanoparticulate gel as a local drug delivery system, when used in conjunction…
- Trial name
- NCT07754253
- Testing
- Ten patients with stage II periodontitis will receive epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets, chitosan nanoparticulate gel (CTN gel), scaling and root planing (SRP) only.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Inflammatory Bowel Disease
Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy
This investigation is designed to compare lubiprostone and placebo for cleansing and propulsion in preparation for capsule endoscopy.
- Trial name
- NCT00746395
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Child Abuse, Parenting
Malezi Na Kilimo Bora - Skilful Parenting and Agribusiness Child Abuse Prevention Study
The Malezi ne Kilimo Bora ("Good Parenting and Farming" in Kiswahili) Skilful Parenting and Agribusiness Child Abuse Prevention Study is a collaboration between the University of Oxford, University of Glasgow, and the Tanzania…
- Trial name
- SPACAPS (NCT02633319)
- Testing
- Skilful Parenting, Agrics
- Where
- Tanzania
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Health Behavior, Breast Cancer Screening
Improving Breast Cancer Screening Uptake Through Tailored Reminder Letters
The goal of this trial is to learn whether a culturally and linguistically tailored reminder letter can increase participation in the Flemish Breast Cancer Screening Program among women who previously did not attend screening.
- Conditions
- Health Behavior, Breast Cancer Screening, Mammography
- Trial name
- ENTER (NCT07472036)
- Testing
- Tailored reminder letter
- Where
- 2 sites in Belgium
- Volunteers
- 7,947 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Osteoarthritis
Efficacy and Safety of Cortex Eucommiae (CE: Eucommia Ulmoides Oliver Extract) in Subjects With Mild Osteoarthritis
The purpose of this clinical trial is to evaluate the efficacy and safety of Cortex Eucommiae (CE: Eucommia ulmoides Oliver extract) in subjects with mild osteoarthritis (OA).
- Trial name
- NCT03744611
- Testing
- CE
- Where
- 3 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Bacterial Vaginosis
A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis
This was a two-part, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy (for Part B) of BNT331 in healthy women (Part A) and in women diagnosed…
- Trial name
- NCT06469164
- Testing
- BNT331
- Where
- 6 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Constipation
Adults With Constipation
This randomized, double-blind, placebo-controlled trial will assess the clinical effects of probiotics in adults with functional constipation. Participants will receive probiotics or placebo for 8 weeks.
- Trial name
- NCT07529457
- Testing
- Probiotics
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Postmenopausal Osteoporosis
Treatment Exercises With Core Stability and Dynamic Resistance Exercise for Postmenopausal Women With Osteoporosis
osteoporosis is a common disease that affect most of postmenopausal women. various treatment procedures are used to avoid future complain among postmenopausal population.
- Trial name
- NCT06264401
- Testing
- Alendronate, treatment exercises
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alzheimer's Disease
Gray Matters Alzheimer's Disease Prevention Intervention
This is a randomized controlled trial to develop and test the efficacy of a multi-domain lifestyle behavioral intervention designed to promote healthier lifestyle behaviors linked to lower Alzheimer's disease risk among persons…
- Trial name
- NCT02290912
- Testing
- Health education program
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Utah State University
Dietary Modification
A Trial on the GI of Spaghetti Versus Rice as Mixed Meals
Pasta and rice are two of the most commonly consumed grains worldwide, where the former has a low GI (e.g. spaghetti) and the latter, usually (as it depends on the type) has a higher GI (e.g. white rice).
- Trial name
- NCT03104712
- Testing
- Glucose #1, Glucose #2, Glucose #3
- Where
- Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Parma
Diagnosis
The Impact of Large Language Models on Diagnostic Reasoning Among LLM-Trained Medical Doctors
This study aims to evaluate whether large language model-trained medical doctors demonstrate enhanced diagnostic reasoning performance when utilizing ChatGPT-4o alongside conventional resources compared to using conventional…
- Trial name
- NCT06774612
- Testing
- ChatGPT-4o
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Total Knee Replacement
Action Observation in Knee Replacement
Postoperative rehabilitation is required for a successful outcome following total knee arthroplasty. Traditionally rehabilitative programs aim to increase range of motion, to strengthen quadriceps, to restore normal gait, and to…
- Trial name
- NCT02707419
- Testing
- Experimental group, Control group, Conventional physiotherapy
- Where
- Italy
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Overweight and Obesity
Diet-Induced Variability in Appetite (DIVA)
The aim of this study is to test the hypothesis that dietary weight loss (WL) through alternate day fasting (ADF) will enhance appetite control, health markers and wellbeing following WL compared to standard daily calorie…
- Trial name
- DIVA (NCT03447600)
- Testing
- Alternate Day Fasting, Continuous dietary restriction
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Episiotomy
Adhesive Tape in Episiotomy Repair
This study will be undertaken to question the superiority of use skin adhesive tape (® Steri-Strip) closure system in wound healing over the traditional running absorbable subcuticular suture technique in perineal repair after…
- Trial name
- NCT02608671
- Testing
- Skin adhesive tape
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hyperlipidemias, Hypertension
Evaluating the Pharmacokinetic Interaction Between AD-2011 and AD-2012
The purpose of this study is to evaluate the Pharmacokinetic Interaction Between AD-2011 and AD-2012 in healthy male volunteers.
- Trial name
- NCT03586037
- Testing
- AD-2011 10/20 mg, AD-2012 80mg, AD-2011 10/20 mg + AD-2012 80mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Maternal and Child Health
An Innovative Mobile Technology Intervention for Maternal and Child Health Care in Cambodia
The Innovative Mobile Technology for Maternal and Child Health Care (i-MoMCARE) project is a digital health intervention aiming to increase the coverage of and access to maternal and child health (MCH) services for pregnant women…
- Trial name
- i-MoMCARE (NCT05639595)
- Testing
- Web interface for health center staff and mobile application on smart phones for village health volunteers
- Where
- Cambodia
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
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