Clinical trials: Randomized Controlled Trial (RCT)
Potentially Avoidable Hospitalisations
Implementation and Evaluation of a Complex Intervention to Reduce Avoidable Transitions Between Nursing Home and Hospital
Hospital admissions can have a negative impact on the physical and emotional health of nursing home residents. Although evidence-based interventions have been developed to reduce hospitalisations, the evidence regarding their…
- Trial name
- RATHER-NH (NCT07359521)
- Testing
- RATHER-NH Toolkit
- Where
- 6 sites in Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Social Isolation, Loneliness
Intergenerational Program for Social Isolation and Loneliness in Older Adults Discharged From the Emergency Department
Social isolation and loneliness worsens older adults' risk of dementia, quality of life, and death as much as smoking. Older adults are more likely to use emergency services and are also more likely to experience social isolation…
- Conditions
- Social Isolation, Loneliness, Geriatric
- Trial name
- SIL (NCT05998343)
- Testing
- Intergenerational HOW R U?, Same-Generation Peer Support HOW R U?
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
HIV Prevention
Couples in Context: An RCT of a Couples-based HIV Prevention Intervention
The prevalence for human immunodeficiency virus (HIV) in South Africa is 18% among 15-49 year old adults and 30% among female antenatal clinic attendees (UNAIDS, 2007), indicating continuing need for effective HIV prevention.
- Trial name
- NCT01953133
- Testing
- Couples Counselling Sessions
- Where
- South Africa
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Small Bowel Disease
Novel Motorized Spiral Enteroscopy Vs Single Balloon Enteroscopy In Patients With Small Bowel Disorders- A RCT
STUDY OBJECTIVES: 1. Primary objective: Rate of total enteroscopy (TER) by means of NMSE or SBE with: Complete antegrade approach or combined antegrade and retrograde approach 2. Secondary objective: 1.
- Trial name
- MOTOR-AIG-01 (NCT05548140)
- Testing
- Novel Motorized Spiral Enteroscopy
- Where
- 2 sites in India
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Hip Pain Chronic, Anesthesia
Hip Arthroscopy Pain Control Randomized Control Trial (RCT)
Femoroacetabular impingement is a pathologic process within the hip joint that results from a mechanical discord between the femoral head and neck and the acetabulum that results in chronic hip pain, hip labral tears and early…
- Conditions
- Hip Pain Chronic, Anesthesia, Bupivacaine
- Trial name
- NCT02947178
- Testing
- Fascial iliac regional soft tissue infiltration blockade, Pain Score Survey, Pill Count
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Knee Osteoarthritis
RSA of the ATTUNE Knee System: RCT Comparing Traditional Vs Enhanced-Fixation Device Designs
The principal objective of this study is to compare migration patterns between the Attune and Attune S+ PS knee systems using model-based RSA over the first 2 post-operative years.
- Trial name
- NCT03554720
- Testing
- ATTUNE PS Knee, ATTUNE S+ PS Knee
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Mild Cognitive Impairment, The Cognitive Normal Elderly
The Effects of Multidomain Non-pharmacological Interventions on the Elderly With or Without Mild Cognitive Impairment
The study aiming to investigate the efficacy, safety, and potential mechanism of a multimodal intervention on cognitive function in individuals with MCI or the cognitive normal elderly living in a community.
- Trial name
- NCT05483790
- Testing
- the multimodal intervention
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Vaccine Hesitancy, Vaccine Acceptance
Development and Evaluation of a Digital Educational Intervention to Improve Vaccine Confidence and Communication Among Registered Nurses: Protocol for a Randomized Controlled Trial (VaxNurse-RCT).
Nurses play an important role in providing vaccine information and supporting informed vaccination decisions. This study will evaluate a digital educational intervention designed for registered nurses in Quebec.
- Trial name
- VaxNurse-RCT (NCT07859579)
- Testing
- Digital educational intervention
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Assisted Reproductive Technology, Antibiotic Prophylaxis
Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT
The objective of this study is to determine the impact on clinical pregnancy rate of withholding routine prophylactic antibiotic therapy during IVF.
- Conditions
- Assisted Reproductive Technology, Antibiotic Prophylaxis, Embryo Transfer
- Trial name
- PAPET (NCT03386227)
- Testing
- Withholding antibiotic prophylaxis
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Physical Inactivity
ACtive Children Enhance LEaRning and AttenTION: A Randomized Controlled Trial (RCT)
The goal of this clinical trial is to test the effectiveness of sport-based physical education (PE) curriculum on activity behaviors (moderate to vigorous physical activity and sedentary behavior), executive functions, and…
- Trial name
- ACCELERATION (NCT05794360)
- Testing
- ACtive Children Enhance LEaRning and AttenTION (ACCELERATION)
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- University of Houston
Parkinson Disease
DB RCT for Specialized Phototherapy in Parkinson's Disease.
This is a pivotal study to determine whether light therapy can improve non-motor and motor function in Parkinson's disease, on top of current best medical treatment.
- Trial name
- LIGHT-PD (NCT04453033)
- Testing
- Celeste Specialized Phototherapy Device
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- PhotoPharmics, Inc.
Neonatal Infections
Neonatal Package Study in Rural District of Pakistan
Neonatal mortality has been a notable health issue in Pakistan. Considering the importance of the issue and well recognized interventions the investigators are proposing a randomized controlled trial in a rural district of…
- Trial name
- NCT02279381
- Testing
- Chlorhexidine, Kangaroo Mother Care, Essential Neonatal Care
- Where
- Pakistan
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Atrial Fibrillation
Blinded Randomized Controlled Trial of Artificial Intelligence Guided Detection of Intracardiac Thrombus
To determine whether an integrated AI decision support can save time and improve the accuracy of detection of intracardiac thrombus, the investigators are conducting a blinded, randomized controlled study of AI-guided detection…
- Trial name
- NCT06206187
- Testing
- Automated detection of the intracardiac thrombus through deep learning, Electrophysiologist judgment of the intracardiac thrombus
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
TMJ Disc Disorder
Assessment of Concentric Needle Technique in Temporomandibular Joint (TMJ) Internal Derangement.
The aim of the study is to evaluate the effectivenes of using two concentric needles in comaprsion with the normal traditional two distant needles.
- Trial name
- NCT05510336
- Testing
- Arthrocentesis
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries Prevention
Effectiveness of Using (Vanish XT) in Prevention of Occlusal Caries: a RCT
Despite the continuous effort to prevent and treat dental caries, it continues to be one of the most common chronic diseases in both children and adults.
- Trial name
- NCT04579536
- Testing
- Light curable resin modified glass ionomer varnish, Vanish White Varnish
- Where
- Saudi Arabia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Guided Bone Regeneration, Dental Implant
RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A
The aim of this randomized controlled trial is to evaluate the tridimensional bone stability after horizontal one-stage GBR using collagene membrane (OssMem) with a mix of Bovine Bone Substitute (A-Oss) and autogenous bone (test…
- Trial name
- NCT06286605
- Testing
- A-oss and autogenous bone, A-oss an LCR-A
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Program Effectiveness, Program Implementation
Implementation Study With Embedded RCT of a Digital System of Parenting Support Within Government Services in South Africa
ParentText, a WhatsApp-based parenting support programme, is designed as a universal intervention to improve parent-child relationships (module 1) and promote child safety (module 2).
- Conditions
- Program Effectiveness, Program Implementation, Parent Child Relationship, Caregiver Child Relationship
- Trial name
- SWIFT (NCT07814261)
- Testing
- Module 1 - Improve My Relationship with My Teen/Child, Module 2 - Keep My Child/Teen Safe and Healthy
- Where
- South Africa
- Volunteers
- 4,961 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Gingivitis
Flossing With Chlorhexidine
To determine if flossing with a dental floss presoaked in chlorhexidine, an anti-microbial mouth wash, would improve the clinical signs of gingivitis, an inflammation of the gums characterized by red, swollen, bleeding gums.
- Trial name
- NCT00471783
- Testing
- Chlorhexidine is the generic name of the mouthwash, Peridex is the brand name.
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Computer, Screening
Computer-assisted Psychosocial Risk Assessment (CaPRA) for Refugee Health and Settlement
The purpose of this study was to examine preliminary effect of Computer-assisted Psychosocial Risk Assessment tool (CaPRA) among Afghan refugees visiting medical professionals (family physicians or nurse practitioners) at a…
- Conditions
- Computer, Screening, Decision Support System, Primary Care
- Trial name
- CaPRA (NCT01427829)
- Testing
- Computer-assisted Psychosocial Risk Assessment (CaPRA)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Surgical Wound
Reconstruction Flaps for Nasal Surgical Wounds RCT
The purpose of this study is to determine whether there is a significant difference in aesthetic and functional outcomes between nasalis sling flaps and lobed flaps of nasal tip wounds requiring reconstruction.
- Trial name
- NCT04729231
- Testing
- Nasalis Sling Flap, Lobed Transposition Flap
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University