Clinical trials: Randomized-controlled Trial
Anxiety, Pain
Music Use in Parturients Admitted to Labor & Delivery
The goal of this clinical trial is to learn if music use affects anxiety or pain levels in parturients admitted to labor and delivery. It will also learn about the effect of music use on patient satisfaction.
- Conditions
- Anxiety, Pain, Patient Satisfaction
- Trial name
- NCT06969105
- Testing
- Music
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Heart Failure, Myocardial Infarction
Transcultural Digital Solutions in Phase III Cardiac Rehabilitation
Multicenter Prospective Controlled Randomized Trial, open-label, in patients with atherosclerotic cardiovascular disease (ASCVD) (acute coronary syndrome or chronic coronary syndrome and ischemic heart failure) and an approved…
- Trial name
- COMPASS (NCT07252856)
- Testing
- DEEPER
- Where
- 6 sites in Belgium, Italy and 2 more
- Volunteers
- 306 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cirrhosis, Liver
Rotational Thromboelastometry Guided Blood Component Use in Children With Cirrhosis Undergoing Invasive Procedures: A Randomized Controlled Trial
Blood products are commonly used before invasive procedures in patients with end-stage liver diseases despite cirrhosis being a thrombophilic state.
- Trial name
- NCT04460222
- Testing
- Rotational Thromboelastometry to guide blood product transfusion pre invasive procedure, Conventional transfusion methods to guide blood product transfusion pre invasive procedure
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Healthy
Comparison of Dietary Fats on Vascular Parameters
The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels.
- Trial name
- COIL (NCT01876394)
- Testing
- Coconut Oil, Canola Oil, Grapeseed Oil
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Fitness Trackers, Sedentary Time
Fullscale_Intervention Study: Genetic Risk Communication in Coronary Heart Disease and Wearables
Background: This study aims to determine the effects of communicating genetic risk for Coronary Heart Disease (CHD) alone or in combination with goal setting and prompts from a wearable device on objectively measured sedentary…
- Conditions
- Fitness Trackers, Sedentary Time, Genetic Predisposition to Disease, Coronary Heart Disease
- Trial name
- NCT05789966
- Testing
- Genetic Risk Estimate+Health Coaching, Genetic Risk Estimate + Fitbit Functions+Health Coaching
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Periodontal Bone Defects
Minimally Invasive Non-surgical Therapy With or Without Injectable Bone Putty
All periodontitis patients with infra bony pockets to be included in this study will diagnosed as having stage III periodontitis with probing pocket depth (PPD) ≥ 6 mm, and clinical attachment loss (CAL) ≥ 5mm will be treated by…
- Trial name
- NCT06553222
- Testing
- Putty bone - Tricalcium phosphate with Collagen gel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Psoriasis
A Safety and Efficacy Study of Infliximab (Remicade) in Patients With Plaque Type Psoriasis
The purpose of the study is to evaluate the effectiveness and safety of infliximab (Remicade) in patients with plaque-type psoriasis.
- Trial name
- NCT00230529
- Testing
- infliximab
- Volunteers
- 249 people
- Sponsor
- Centocor, Inc.
Inflammatory Bowel Disease
Integrated Care for Inflammatory Bowel Disease Patients in the Netherlands With the Novel Telemedicine Tool myIBDcoach: a Randomized Controlled Trial
Inflammatory bowel diseases (IBD) is an invalidating disease mainly diagnosed in young people. The disease is characterized by a heterogenic phenotype and the disease course by flares and remissions.
- Trial name
- myIBDcoach (NCT02173002)
- Testing
- myIBDcoach, Standard care
- Where
- Netherlands
- Volunteers
- 909 people
- Sponsor
- Maastricht University Medical Center
Healthy Volunteers
A Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of PF-03882845 In Healthy Volunteers
To evaluate the safety and tolerability of PF-03882845 in Healthy Volunteers. To evaluate the pharmacokinetics of PF-03882845 in Healthy Volunteers. To evaluate the pharmacodynamics of PF-03882845 in Healthy Volunteers.
- Trial name
- NCT00971802
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer
Septic Shock
Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of a systemic inflammatory response syndrome (SIRS) in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high…
- Trial name
- EXCHANGE (NCT03065751)
- Testing
- Plasmaexchange
- Where
- Germany
- Volunteers
- 352 people
- Sponsor
- Hannover Medical School
Hypertension, Obstructive Sleep Apnea
Effect of Antihypertensive Agents Over Sleep Apnea
Obstructive sleep apnea and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations.
- Trial name
- NCT01896661
- Testing
- Diuretics, Calcium Channel Blockers
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Kidney Disease
Impact of HemoDiaFIltration on Physical Activity and Self- Reported Outcomes
This is a randomized controlled clinical trial that will analyze the impact of high volume online HDF in comparison to high-flux HD on measured physical activity.
- Trial name
- HDFIT (NCT02787161)
- Testing
- Hemodiafiltration, Hemodialysis
- Where
- 13 sites in Brazil
- Volunteers
- 195 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Stellate Ganglion Block
Effects of Stellate Ganglion Block on Delirium and Circadian Rhythm in Geriatric Intensive Care Patients
Delirium is a common complication in elderly intensive care unit (ICU) patients and is associated with poor clinical outcomes. Circadian rhythm disruption is considered an important contributing factor in delirium development.
- Trial name
- NCT07558642
- Testing
- stellate ganglion block with 0.5% bupivacaine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Antalya Training and Research Hospital
Shoulder Surgery, Nerve Block
The Effects of Dexamethasone on Low Dose Interscalene Brachial Plexus Block
A standard interscalene nerve block is performed with long acting local anesthetic (bupivacaine or ropivacaine in concentrations varying from 0.25% to 0.75%).
- Trial name
- ISB-Dex (NCT02322242)
- Testing
- Systemic Dexamethasone, Perineural dexamethasone
- Where
- Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Dr. Stephen Choi
Surgical Extraction of Impacted Third Molars
The Use of Manuka Honey to Improve Healing After Third Molars Surgery
Since there is an evidence that Manuka honey is an antibacterial agent, the present study aims to confirm this characteristic and assess its effect in improving healing and reducing postsurgical symptoms, if topically applied…
- Trial name
- NCT02483741
- Testing
- Manuka Honey
- Where
- Syria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Damascus University
Shivering, Adverse Effects in the Therapeutic Use of Anaesthetic
Nefopam Versus Ondansteron for Prevention of Post Spinal Shivering.
Spinal anesthesia affects the homeostatic systems resulting in intraoperative hypothermia and subsequently shivering. In fact, shivering may be seen after this technique in 30 to 40% of cases .
- Trial name
- NCT04870541
- Testing
- Ondansetron 8mg, Nefopam Injectable Solution
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- Saint-Joseph University
Cognitive Impairment, Cognitive Flexibility
The Effects of Single Exercise Sessions on Cognitive Flexibility and Brain Functional Connectivity in Older Adults With Cognitive Impairment
Objectives: To investigate the effects of different forms (physical and mental, aerobic and resistance) of single exercise on the cognitive flexibility and brain functional connectivity of elderly individuals with cognitive…
- Trial name
- NCT07623954
- Testing
- EXERCISE TRAINING, health education materials
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Sport
Acute Myeloid Leukemia
GRASPA Treatment for Patients With Acute Myeloblastic Leukemia
The protocol aims at adding GRASPA (L-asparaginase encapsulated in red blood cells, eryaspase) to standard chemotherapy (low-dose cytarabine) to treat patients older than 65 years diagnosed with AML and unfit for intensive…
- Trial name
- ENFORCE (NCT01810705)
- Testing
- GRASPA
- Where
- 21 sites in France
- Volunteers
- 123 people
- Sponsor
- ERYtech Pharma
Ringer Bicarbonate, Elderly Abdominal Surgery
Safety and Efficacy of Sodium Bicarbonate Ringer Injection
Objectives 1. To observe whether sodium bicarbonate Ringer injections can reduce the incidence of postoperative complications in elderly patients undergoing abdominal surgery. 2.
- Conditions
- Ringer Bicarbonate, Elderly Abdominal Surgery, Safety, Effectiveness
- Trial name
- NCT04596956
- Testing
- sodium bicarbonate Ringer injection, Lactated Ringer's solution
- Volunteers
- 5,000 people
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer, Opioid-free Anesthesia
Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery
Adult patients aged 18-80 years old, American Society of Anesthesiologists physical status I-III, who were scheduled for elective colorectal cancer surgery under general anesthesia were recruited for this study.
- Conditions
- Colorectal Cancer, Opioid-free Anesthesia, NETs
- Trial name
- NCT07264556
- Testing
- OA strategy, OSA stategy, OFA strategy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fudan University
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