Clinical trials: Rapid Sequence Intubation
Intubation in Intensive Care Units
Delayed Against Rapid Sequence Induction in Adults With Medical Diseases Undergoing Emergency Endotracheal Intubation.
The goal of this clinical trial is to learn if it is feaseble to conduct a superiority trial comparing two methods for endotracheal intubation in critically ill patients.
- Trial name
- DARSITUBE (NCT06940219)
- Testing
- Delayed Sequence Induction, Modified Rapid Sequence Induction
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Leipzig University Medical Center
Intubation
Biphasic Ventilation Airway Management Clinical Trial
Investigators intend to determine if the use of Biphasic Cuirass Ventilation (BCV) improves patient safety (avoiding hypoxia) during emergency rapid sequence intubation .
- Trial name
- BVAM (NCT03042598)
- Testing
- Biphasic Cuirass Ventilation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University Medical Center of Southern Nevada
Diffuse Apneic Oxygenation
EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
To determine the impact, if any the application of oxygen during the apnea period of rapid sequence intubation has on patients being intubated in the emergency department.
- Trial name
- ENDAO (NCT02737917)
- Testing
- Oxygen, Standard of care
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- New York City Health and Hospitals Corporation
Endotracheal Intubation in Bed up Head Elevation Position in Rapid Sequence Induction
Comparison of Bed up Head Elevated Position With Sniffing Position in Rapid Sequence Induction.
This study is aimed to conduct a randomised controlled trial comparing endotracheal intubation (ETI) in bed up head elevation BUHE position versus sniffing position in simulated rapid sequence induction (RSI).
- Trial name
- NCT03912935
- Testing
- comparison between two different intubating position
- Where
- Malaysia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University
Intra-tracheal Intubation
Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant
REMICrush is a French multicentric non inferiority simple blind randomized clinical trial that will compare the use of Remifentanil to muscle relaxant (reference treatment) for anesthetic rapid sequence intubation in terms of…
- Trial name
- REMICRUSH (NCT03960801)
- Testing
- Remifentanil group, neuromuscular blockade group
- Where
- 13 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Nantes University Hospital
Critically Ill Adults Requiring Emergency Tracheal Intubation in the Intensive Care Unit
Propofol or Esketamine: Tracheal Intubation Comparison
The goal of this clinical trial is to compare how esketamine and propofol affect blood pressure in critically ill adults who need a breathing tube in an intensive care unit (ICU).
- Trial name
- POETIC (NCT07847255)
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Intubation, Intratracheal, Rapid Sequence Induction and Intubation
Community Medical Center, Continuous Quality Improvement Project, Rapid Sequence Intubation
To assess the ongoing continuous quality improvement of rapid sequence intubation in our emergency department. Ongoing assessment will address standardization of the process and protocol driven measures that will improve the…
- Conditions
- Intubation, Intratracheal, Rapid Sequence Induction and Intubation, Checklist
- Trial name
- NCT05505799
- Testing
- Intubation Checklist, Standard Care
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Community Medical Center, Toms River, NJ
Surgery
McGrath Videolaryngoscopy and Direct Laryngoscopy Rapid Sequence Intubation
The study seeks to compare the efficacy of conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for rapid sequence endotracheal intubation.
- Trial name
- NCT05850052
- Testing
- McGrath videolaryngoscope for rapid sequence endotracheal intubation, Conventional direct laryngoscopy using a Macintosh blade
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- The Cleveland Clinic
Rapid Sequence Intubation
Rapid Sequence Intubation With Rocuronium-Sugammadex Compared With Succinylcholine
Rapid sequence intubation is used, when there is an elevated risk of aspiration to the lungs of stomach content. It is typically used in acute settings that require acute surgery or in prehospital settings, but also in specific…
- Trial name
- NCT00953550
- Testing
- Rocuronium-Sugammadex, Succinylcholine
- Where
- 2 sites in Denmark
- Volunteers
- 61 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Peri-intubation Hypotension
Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department
Rapid sequence intubation is commonly performed in the emergency department to secure the airway of critically ill patients. However, blood pressure may decrease during or shortly after intubation because of the patient's…
- Trial name
- NCT07620327
- Testing
- Adrenaline, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Aspiration of Gastric Contents, Gastric Emptying
The Effect of Intravenous Erythromycin on Gastric Emptying in Non-fasted Patients Before Emergency Total Anesthesia
In this study the investigators want to investigate the effect of a short intravenous infusion of Erythromycine on gastric emptying on patients considered "full stomac" and scheduled for Emergency operation.
- Trial name
- NCT00827216
- Testing
- Erythromycin
- Where
- Switzerland
- Volunteers
- 132 people
- Sponsor
- University Hospital, Geneva
Pulmonary Aspiration of Gastric Contents
Videolaryngoscopy Compared to Direct Laryngoscopy
Videolaryngoscope (Macintosh-type blade) compared with direct laryngoscopy for rapid sequence intubation in the operating room
- Trial name
- LARA (NCT04794764)
- Testing
- McGrath Mac, Macintosh Laryngoscope
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Critical Illness, Hypoxia
End-Tidal Oxygen for Intubation in the Emergency Department
Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation.
- Conditions
- Critical Illness, Hypoxia, Respiratory Failure
- Trial name
- PREOXED (NCT06578468)
- Testing
- End-tidal oxygen monitor
- Where
- 9 sites in United States, Australia
- Volunteers
- 1,400 people
- Sponsor
- Sydney Local Health District
Intubation
Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)
Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability.
- Trial name
- NCT00783731
- Testing
- Low dose midazolam
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Hypoxemia, Airway Management
Comparison of High-Flow Nasal Cannula and Tight Face Mask for Maintaining Oxygenation During Rapid Sequence Induction
This prospective randomized controlled trial aims to compare the effectiveness of High-Flow Nasal Cannula (HFNC) versus Tight Face Mask (TFM) in maintaining oxygenation during rapid sequence induction (RSI) for endotracheal…
- Conditions
- Hypoxemia, Airway Management, Endotracheal Intubation, Rapid Sequence Induction
- Trial name
- NCT07723430
- Testing
- High-Flow Nasal Cannula, Tight Face Mask
- Volunteers
- 290 people
- Sponsor
- Khyber Teaching Hospital
Bradycardia, Hypotension
Determination of Remifentanil's ED50 for Rapid Sequence Intubation Avoiding Bradycardia and Hypotension in Adults
This study will find the median effective dose of remifentanil for rapid sequence intubation which avoids bradycardia and hypotension
- Trial name
- NCT03065309
- Testing
- Remifentanil
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Brasilia University Hospital
Airway Control
Rapid Sequence Intubation Drug Delivery Using Intraosseous and IV Access in Pediatric Patients Observational Study
This study will evaluate using intraosseous vascular access and intravenous vascular access to give pediatric patients the necessary medications to perform rapid sequence intubation, for patients with airway difficulties.
- Trial name
- NCT01634867
- Where
- United States
- Sponsor
- Vidacare Corporation
Rapid Sequence Induction and Intubation
Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment
This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.
- Trial name
- NCT05725031
- Testing
- Ephedrine, Rocuronium 0.6, Rocuronium 0.8
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Anesthesia Intubation Complication
Modified Rapid Sequence Induction in Morbidly Obese Patients
This study investigates the effect of 4 different methods of rapid sequence induction (RSI) in morbidly obese patients on the amount of air insufflation into the stomach.
- Trial name
- NCT03239236
- Testing
- Rapid sequence induction t-RSI, Rapid sequence induction m-RSI-PEEP, Rapid sequence induction m-RSI-vent
- Where
- Austria
- Sponsor
- Medical University of Vienna