Clinical trials: Reactions Adverse
DNA Sequencing
Ivermectin Neurotoxicity and ABCB1 Gene Mutations
The study report a unique case of severe intoxication in a child treated with oral ivermectin to prevent scabies infection. The ABCB1 gene sequencing found the child compound heterozygote for two nonsense mutations, one in each…
- Trial name
- NCT04174469
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier
Tinnitus, Hearing Loss
Tinnitus and Arterial Hypertension
Many authors link tinnitus to arterial hypertension. The aim of this study is to establish a possible relationship between them, analyze the severity of tinnitus related to arterial hypertension and analyze a possible influence…
- Conditions
- Tinnitus, Hearing Loss, Arterial Hypertension
- Trial name
- NCT01333683
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina de Valenca
Shortness of Breath, Asthma in Children
The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome
Our study aiming to look in improvement of Pediatric Respiratory Assessment Measure (PRAM) score as a primary outcome. The secondary outcomes involving the need for second step management, need for admission and possible side…
- Conditions
- Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use, Salbutamol Adverse Reaction
- Trial name
- NCT05667727
- Testing
- nebulized epinephrine, Salbutamol
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Medical Speciality Board
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Drug Hypersensitivity
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase.
- Trial name
- NCT00198458
- Testing
- Vitrase
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Adverse Drug Event, Drug Drug Interaction
Implementation of a Pharmacist-led Pharmacogenomic Clinical Service
Tabula Rasa HealthCare (TRHC), doing business as CareKinesis, is the first national pharmacy that provides science-based medication risk identification and mitigation technologies and services.
- Conditions
- Adverse Drug Event, Drug Drug Interaction, Pharmacogenomics, Elderly
- Trial name
- NCT04984538
- Testing
- Pharmacogenomic Testing
- Where
- United States
- Sponsor
- Tabula Rasa HealthCare
Metabolic Disturbance, Hyperprolactinemia
Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment
The goal of this clinical trial is to explore the potential of metformin in managing olanzapine-induced metabolic disturbance and hyperprolactinemia in patients with schizophrenia. The main questions it aims to answer are: 1.
- Conditions
- Metabolic Disturbance, Hyperprolactinemia, Schizophrenia
- Trial name
- NCT06326840
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Taipei Medical University Hospital
Dyskinesia, Medication-induced
Levetiracetam in the Treatment of Neuroleptic-induced Tardive Dyskinesia
An 8-week study to examine safety and efficacy of levetiracetam in patients with neuroleptic-induced tardive dyskinesia
- Trial name
- NCT00175955
- Testing
- Levetiracetam
- Where
- 7 sites in Belgium, Bulgaria
- Volunteers
- 70 people
- Sponsor
- UCB Pharma
Adverse Effect of Cardiovascular Medications (Diagnosis)
Effect of PCSK9 Inhibitor on Retinal Microvessels in Patients With Coronary Heart Disease After Intensive Lipid-lowering Therapy
In patients with coronary heart disease who were treated with PCSK9 inhibitor evolocumab for intensive lipid-lowering therapy, the changes of retinal microvessels were measured with OCTA (Optical Coherence Tomography…
- Trial name
- NCT05802108
- Testing
- Evolocumab combined with statins, Statin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zibo Central Hospital
In Vitro Fertilization, Stress
What Amount of Stress is Enough for a Successful Conception?
The aim of the study is to determine whether premedication with midazolam before oocyte aspiration in IVF procedures affects the amount of (oxidative) stress in women undergoing IVF and whether stress is also transmitted to the…
- Conditions
- In Vitro Fertilization, Stress, Midazolam Adverse Reaction, Stress, Emotional
- Trial name
- NCT04160611
- Testing
- Midazolam 7.5mg
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University Hospital Sestre Milosrdnice
Early-stage Breast Cancer
Cardioprotective Effect of Acute Exercise in Breast Cancer Patients
Cardiotoxicity is one of the most significant adverse effects in breast cancer patients treated with anthracyclines (a type of chemotherapy), so we propose to determine whether acute training (i.e., 24h before each chemotherapy…
- Trial name
- CardioProtEx (NCT05467111)
- Testing
- Acute Exercise
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Technical University of Madrid
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Capsule.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Capsule (XLGB Capsule) through a non-intervention observational way.
- Trial name
- NCT03091244
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Drug-Induced Liver Injury
A Retrospective Study on Drug Induced Liver Injury in China
This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences…
- Trial name
- DILI-R (NCT02407964)
- Where
- 371 sites in China
- Volunteers
- 15,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease
Efficacy of Phentolamine in Prevention of Contrast-Associated Acute Kidney Injury After Complex PCI
To evaluate the efficacy and safety of phentolamine in prevention of CA-AKI following complex PCI in patients at high risk of CA-AKI.
- Conditions
- CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease, Acute Coronary Syndrome, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT06286059
- Testing
- Phentolamine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Helwan University
Cardiotoxicity, HER2-positive Breast Cancer
Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction
Breast cancer is the most common cancer in the United Kingdom (UK), but improvements in treatment mean 3 in 4 people survive for more than 10 years.
- Conditions
- Cardiotoxicity, HER2-positive Breast Cancer, Heart Failure, Cancer, Therapy-Related
- Trial name
- HER-SAFE (NCT05880160)
- Testing
- Phased withdrawal of heart failure medications
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University College, London
Allergy Drug, Allergy Penicillin
A Penicillin Allergy Delabeling Inhospital Model Hospitalized Patients
Design, implementation and analysis of an allergy assessment and management model beta-lactams in hospitalized patients
- Trial name
- Des-Al-Pen (NCT07194824)
- Testing
- Pragmatic allergy management according to risk stratification
- Where
- 2 sites in Spain
- Volunteers
- 165 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Breast Cancer
Early Prediction and Warning for Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
This multicenter clinical study aims to build an intelligent and accurate diagnosis and dynamic prediction and early warning model of cardiotoxicity due to anthracycline-based breast cancer chemotherapy, clarify the value of the…
- Trial name
- NCT06282796
- Testing
- Echocardiography
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- First Hospital of China Medical University
Dexamethasone Adverse Reaction, Postoperative Pain
Role of Dexamethasone in Multimodal Analgesia for Postoperative Pain in Thoracic Surgery
The aim of the study is to evaluate the analgesic properties of dexamethasone and to quantify the possible associated postoperative complications, such as wound infections and hyperglycaemia, in patients who underwent lobectomy…
- Conditions
- Dexamethasone Adverse Reaction, Postoperative Pain, Postoperative Thoracic Procedure Complication, Analgesia
- Trial name
- NCT04325984
- Testing
- Dexamethasone
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- University of Trieste
Anesthesia; Adverse Effect, Reflex, Abnormal
The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea
The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.
- Conditions
- Anesthesia; Adverse Effect, Reflex, Abnormal, Tinnitus, Spontaneous Oto-Acoustic Emission
- Trial name
- NCT02062333
- Testing
- Dexmedetomidine, esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- TC Erciyes University
Atrial Fibrillation, Deep Vein Thrombosis
Association Between Genetic Variant Scores and Warfarin Effect
Study objective is to determine whether there is an association between genetic variant risk scores and clinical outcomes (percent time in therapeutic range, time to reach therapeutic international normalized ratio (INR), INR ≥…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Intracardiac Thrombus, Pulmonary Embolism
- Trial name
- AWARE1 (NCT03894878)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cipherome, Inc.
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