Clinical trials: Reading Disorder, open to volunteers
Neurogenetic Diseases
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing
Nucleotide repeats emerge as one of the most prolific classes of genetic variations. They have the propensity to in-crease in length across generations, and have been implicated in at least 65 known neurological/…
- Trial name
- NRGEN-NGS3 (NCT07665554)
- Testing
- Skin biopsy, blood sampling
- Where
- 2 sites in France
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Myopia
Myopia Prevention With Reading Glasses
The last decades have seen a significant increase in myopia in children and young adults. Possible cause: increased near-work (school, computer, smartphone).
- Trial name
- SMART2 (NCT05030103)
- Testing
- Reading glasses, +2.0 diopters
- Where
- Liechtenstein
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Reis Augenklinik AG
Breast Cancer Screening, Artificial Intelligence (AI)
Screening Mammography: Single Reading by One Radiologist With AI vs. Double Reading by Two Radiologists (AI-BCSQ)
A randomized prospective study comparing the evaluation of mammography images in a breast cancer screening programme by a single radiologist with AI support versus standard double reading by two radiologists without AI support.
- Conditions
- Breast Cancer Screening, Artificial Intelligence (AI), Breast Cancer Screening and Diagnosis
- Trial name
- AI-BCSQ (NCT07075679)
- Testing
- Group with AI iCAD version 3, Group without AI
- Where
- Czechia
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Preterm Birth, Developmental Dyslexia
Reading-FREE Markers for Early Detection of Developmental Dyslexia
This study aims to identify early signs of developmental dyslexia (DD) and other reading difficulties in children born preterm, using behavioral, cognitive, and brain imaging data collected before reading problems typically…
- Trial name
- FREE-DD (NCT07072104)
- Testing
- Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 2, MRI - Grade 2, Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 3
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Dyslexia, Developmental, Reading
Enhancing Letter-Speech Sound Learning and Reading Network Activation With Transcranial Electrical Stimulation
This study investigates the effects of transcranial electrical stimulation (tES) on the brain and its potential to enhance reading-related learning.
- Conditions
- Dyslexia, Developmental, Reading, Dyslexia, Learning
- Trial name
- LexiStim (NCT07546292)
- Testing
- Transcranial random noise stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Silvia Brem
Prenatal Diagnosis
Mapping of Genomic Structural Variations in Major Birth Defects
In the context of intricate cases with ambiguous prenatal genetic diagnoses, this project intends to carry out long - read DNA sequencing data analysis on birth defect cases and family samples.
- Trial name
- NCT07515976
- Testing
- Long - read DNA sequencing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc)
Pragmatic RCT of AI-Assisted Reading for Malignant Hepatic Lesions on CE-CT
The purpose of this multicenter pragmatic randomized controlled trial is to determine whether AI-assisted interpretation of multiphasic liver contrast-enhanced computed tomography (CE-CT) is non-inferior to standard radiology…
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Hepatic Metastasis, Hepatic Hemangioma
- Trial name
- NCT07768085
- Testing
- AI-assisted abdominal CE-CT reporting, Standard abdominal CE-CT reporting without AI assistance
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Vestibular Disorder, Hearing Loss, Sensorineural
Reading Outcomes in Children With Vestibular Loss
Vestibular loss can co-occur with hearing loss causing dual sensory deficits. This project examines vestibular loss as a contributing factor to reading difficulties for children with hearing loss, where previously only the…
- Trial name
- NCT05414903
- Testing
- Dynamic Visual Acuity, Reading Outcomes, Static Visual Acuity
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Developmental Dyslexia
Immediate Effects of Active Prisms on Reading Automaticity and Motor Control in Young Adults With Developmental Dyslexia
Developmental dyslexia is associated with persistent difficulties in reading automaticity. AUTO-DYS investigates whether a single, brief intervention using active prisms changes the complexity of nonlinear movement dynamics and…
- Trial name
- AUTO-DYS (NCT07868367)
- Testing
- Individually Selected Active Prisms.
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Lille University
Healthy Young Adults, Accommodation Disorder
Study in Young Adults to Understand How Glasses With a Small Reading Addition Affect Focusing and Eye Coordination During Vision Tasks
This clinical study aims to understand how glasses with a small reading addition affect the way the eyes focus and work together in young adults with normal near vision.
- Trial name
- BIPBIP (NCT07859917)
- Testing
- Eye exam, Questionnaires, Washout lenses
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Essilor International
Developmental Dyslexia, Reading Problem
Personalization of Visual Characters and Text-to-Speech (TTS) to Support Learning in Students With Reading Difficulties
Previous research has shown the importance of font type, size and spacing to facilitate text reading in dyslexia. A special automatized procedure was designed to select the most favorable parameters for both text visualization…
- Trial name
- NCT06947512
- Testing
- Seleggo Test
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Down Syndrome
Shared Book Reading to Promote Mental Well-being Among Young People with and Without Down's Syndrome
Abstract Background: With the progress of society and the deepening of people's understanding of Down syndrome (DS), research has shifted focus on how to improve the quality of life and education for young people with DS.
- Trial name
- NCT06813625
- Testing
- Shared book reading intervention
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Macau
Multiple Sclerosis, Clinically Isolated Syndrome
Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis
This project aims to analyze ocular motility problems, visual processing speed and microperimetry, and their relationship with consolidated retinal structural biomarkers (optical coherence tomography, OCT) in patients with…
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis
- Trial name
- NCT05706220
- Testing
- Eye tracking, Microperimetry, Optical coherence tomography (OCT)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Oral Frailty, Depression
Group Reading and Oral Exercise Program for Older Adults
Depression is common among older adults and is often associated with declines in physical and oral health. Non-pharmacological, community-based interventions are needed to support both mental and physical well-being.
- Conditions
- Oral Frailty, Depression, Sarcopenia, Physical Function Decline
- Trial name
- NCT07550335
- Testing
- Reading and Oral Exercise Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Dyslexia
Reading and Stuttering
Dyslexia is a common neurodevelopmental condition, which manifests itself in the form of reading difficulties and occurs in 7-10% of the population (Peterson \& Pennington, 2012).
- Trial name
- NCT06836115
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wafaa Helmy Abdelhakeem
Language Delay, Language Development
Combined Oral Motor Stimulation and Language on Preterm Infant Feeding
This is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings…
- Conditions
- Language Delay, Language Development, Feeding; Difficult, Newborn, Mother-Infant Interaction
- Trial name
- NCT05861531
- Testing
- Oromotor stimulation, Reading curriculum, LENA recording
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Stuttering, Adult
Investigating the SMA's Role in Speech and Reading Fluency in PWS With rTMS
The goal of this clinical trial is to study how a part of the brain called the supplementary motor area (SMA) is connected to speech and reading fluency in adults who stutter.
- Trial name
- NCT06809387
- Testing
- Brain stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medipol University
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Developmental Dyslexia, Developmental Language Disorder
Dynamic Assessment of the Risk for Language and Reading Disorders in Monolingual and Multilingual Children
The project represents the completion of a part of the recently concluded European project MultiMind, in which a computer platform called MuLiMi was developed and validated.
- Trial name
- NCT06937255
- Testing
- computerized Dynamic Assessment
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Lung Cancer, Artificial Intelligence (AI)
The Impact of AI Assistance on Radiologist Performance and Healthcare Costs in LDCT-Based Lung Cancer Screening
AI diagnostic systems show great promise for improving lung cancer screening in community healthcare settings. While not originally designed for primary care, these tools demonstrate capabilities in nodule detection and workflow…
- Conditions
- Lung Cancer, Artificial Intelligence (AI), Randomized Controlled Trial
- Trial name
- NCT06988579
- Testing
- AI
- Where
- China
- Volunteers
- 7,294 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University