Clinical trials: Rectal Cancer, completed
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Colorectal Cancer, Adenomas
Colonoscopy Screening Using a Novel Slim Colonoscope - a Randomized Controlled Trial
The purpose of this study is to compare the performance of a new prototype colonoscope with a standard colonoscope used world-wide today.
- Trial name
- NCT01370928
- Testing
- Olympus PCF-Y0014-L, Standard colonoscope
- Where
- Norway
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Rectal Cancer
Perineal Reconstruction Following eLAPE and Simultaneous Stoma Sublay Reinforcement
This is a prospective, multicenter, single arm, observational pilot study to assess the clinical outcomes of Strattice Reconstructive Tissue Matrix for perineal reconstruction following eLAPE and simultaneous stoma reinforcement.
- Trial name
- PRESSUR (NCT01670851)
- Testing
- Strattice
- Where
- 3 sites in Denmark, Sweden and 1 more
- Volunteers
- 20 people
- Sponsor
- University Hospitals, Leicester
Colorectal Cancer
Comparison of KRAS/BRAF Mutational Status With Conventional Techniques and Plasma Samples Analysis
The goal of this multicenter prospective study is to validate, and ultimately translate in routine clinical practice, the use of plasma analysis of ccfDNA for the determination of KRAS mutation status in mCRC patients.
- Trial name
- KPLEX2 (NCT02784639)
- Testing
- Plasma Analysis of circulating cell free DNA, Tumor tissue analysis of circulating cell free DNA
- Volunteers
- 115 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colorectal Cancer Metastatic
Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or STAT3 Inhibition in Order to Synergise With PD1 Inhibition in Microsatellite Stable, Refractory Colorectal Cancer
This Phase II research project will test the efficacy, safety, and tolerability of an experimental drug combination: either nivolumab and BBI608 or nivolumab and BNC105 in patients with metastatic colorectal cancer who have…
- Trial name
- MODULATE (NCT03647839)
- Testing
- Nivolumab 10 MG/ML, BNC 105, BBI608
- Where
- 14 sites in Australia
- Volunteers
- 90 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Colorectal Cancer, Appendix Cancer
Trial of Intraperitoneal (IP) Oxaliplatin in Combination With Intravenous FOLFIRI
This is a Phase I dose escalation study to determine how much chemotherapy can be safely administered into the abdomen while experiencing the fewest possible side effects.
- Conditions
- Colorectal Cancer, Appendix Cancer, Peritoneal Carcinomatosis
- Trial name
- NCT02833753
- Testing
- Oxaliplatin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Massachusetts, Worcester
Cancer of Rectum
Evaluation of cfDNA as a Marker of Response in Rectal Cancer
A pathological complete response (pCR) after surgery occurs in approximately 20% of rectal cancer patients submitted to neoadjuvant chemotherapy, with apparent survival benefit.
- Trial name
- NCT04319354
- Testing
- Analysis of cfDNA
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Hospital Pedro Hispano
Metastatic Colorectal Cancer
Capecitabine and Oxaliplatin Plus Bevacizumab as Neoadjuvant Treatment for Untreated Unresectable Liver-only Metastases From Colorectal Cancer
To evaluate the overall response rate of patients with previously untreated unresectable liver-only metastases from colorectal cancer treated with neoadjuvant capecitabine and oxaliplatin plus bevacizumab.
- Trial name
- NCT01022541
- Testing
- Capecitabine, Oxaliplatin, Bevacizumab
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Solid Tumor, Colorectal Cancer
Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer
Prospective, open label, multi-dose, sequential dose escalation, single-center, Phase 1 trial
- Conditions
- Solid Tumor, Colorectal Cancer, Sigmoid Colon Cancer, Rectosigmoid Junction Cancer
- Trial name
- NCT05943041
- Testing
- GB104(Level 1), GB104(Level 2), GB104(Level 3)
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- GILongevity
Colorectal Cancer, Breast Cancer
Tumor-Derived FGF19
Identify and test thresholds, specificity and sensitivity for a potential cancer associated biomarker protein, FGF19, (and associated markers) for detection in human blood in the blood of breast and colorectal in cancer patients…
- Conditions
- Colorectal Cancer, Breast Cancer, Healthy
- Trial name
- NCT06068257
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Gynaecological, Urological or Rectal Cancer
Prospective Study in Pelvic Radiotherapy Patients
Symptoms such as diarrhoea and abdominal discomfort are common side effects of radiotherapy for tumours in the pelvis and usually occur within 2 weeks of starting treatment.
- Trial name
- NCT00220181
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer, Lung Metastases
AI Prediction Model and Risk Stratification for Lung Metastasis in Colorectal Cancer
Background: To assist clinicians with diagnosis and optimal treatment decision-making, we attempted to develop and validate an artificial intelligence prediction model for lung metastasis (LM) in colorectal cancer (CRC) patients.
- Trial name
- NCT05816902
- Testing
- The location of the patient's treatment
- Volunteers
- 2,779 people
- Sponsor
- Peking Union Medical College
Esophageal Cancer, Colorectal (Colon or Rectal) Cancer
Quantitative Fluorescence Angiography With ICG for Perfusion Assessment During Surgery
The accurate assessment of intraoperative tissue perfusion is essential in any branch of surgery. Anastomotic leakage (AL) is one of the most feared complications following gastrointestinal surgery, with potentially threatening…
- Trial name
- SPY Q-ICG PAS (NCT05489757)
- Testing
- SPY Portable Handheld Imaging (SPY-PHI) System with SPY-QP Software
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- IRCCS San Raffaele
Colorectal Cancer, Colorectal Neoplasms
The Impact of Choice on Colorectal Cancer Screening
In May of 2021, the United States Preventive Service Task Force (USPSTF) updated their colorectal cancer (CRC) screening guidelines by recommending screening at an earlier age for average-risk adults starting at the age of 45…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Health Screening
- Trial name
- CRC45+ (NCT05275530)
- Testing
- Active FIT Choice, Active Colonoscopy Choice, Active Dual Choice
- Where
- 2 sites in United States
- Volunteers
- 20,509 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Colon Adenocarcinoma, Colorectal Carcinoma
Optimization of Adaptive Text Messages for Cancer Survivors (OATS II)
This clinical trial evaluates whether an adaptive text-message intervention is useful in helping survivors of colorectal cancers (CRC) eat more whole grain foods and less refined grain foods.
- Conditions
- Colon Adenocarcinoma, Colorectal Carcinoma, Rectal Adenocarcinoma
- Trial name
- NCT05746195
- Testing
- Dietary intervention via Text Messaging, Survey Administration, Nutrition Education
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Francisco
Rectal Cancer
Comparison of Preoperative and Postoperative Radiotherapy and Capecitabine in Locally Advanced Rectal Cancer
Based on the potential advantaged of preoperative chemoradiotherapy and oral fluoropyrimidine, the investigators planned a prospective randomized phase III trial which compares preoperative chemoradiotherapy and postoperative…
- Trial name
- NCT01186081
- Testing
- Preoperative chemoradiotherapy, Postoperative chemoradiotherapy
- Where
- South Korea
- Volunteers
- 240 people
- Sponsor
- Asan Medical Center
MSI-H Colorectal Cancer
Predictive Value of DNA Mismatch Repair System in Colorectal Cancers
Microsatellite instable (MSI) tumors represent almost the 15% of all sporadic colorectal cancers (CRCs). Literature data show that this unique tumor population appears to be poorly responsive to conventional chemotherapy and…
- Trial name
- DNAMMR (NCT05871567)
- Testing
- colorectal resection
- Volunteers
- 403 people
- Sponsor
- University of Campania Luigi Vanvitelli
Colorectal Cancer, Familial Adenomatous Polyposis
Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis
This randomized phase II trial studies how well giving celecoxib with or without eflornithine works in preventing colorectal cancer in patients with familial adenomatous polyposis.
- Trial name
- NCT00033371
- Testing
- Celecoxib, eflornithine, Laboratory biomarker analysis
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Metastatic Cancer
Fludeoxyglucose F 18-PET Imaging for Early Detection of Residual Disease in Patients Undergoing Radiofrequency Ablation of Liver Metastases From Colorectal Cancer
RATIONALE: Diagnostic procedures, such as fludeoxyglucose F 18-PET imaging, may be effective in detecting residual disease after radiofrequency ablation of liver metastases in patients with colorectal cancer.
- Trial name
- NCT00499395
- Testing
- positron emission tomography, radiofrequency ablation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
Cytokine Changes After Colorectal Cancer Resection
Based on our previous research, this study aims to determine reliable surgical stress response markers in patients undergoing radical resection of colorectal cancer.
- Trial name
- NCT01244022
- Testing
- colorectal cancer resection
- Where
- Croatia
- Volunteers
- 28 people
- Sponsor
- University Hospital Dubrava
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