Clinical trials: Rectal Cancer, completed
ColoRectal Cancer, Liver Metastases
Simultaneous Resection of Colorectal Cancer With Synchronous Liver Metastases
Synchronous colorectal cancer with liver metastases, defined as the diagnosis of a primary colorectal tumour and liver metastases within 12 months, is a common problem faced by colorectal and hepatobiliary surgeons.(Adam) The…
- Conditions
- ColoRectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer, Surgery
- Trial name
- RESECT (NCT02954913)
- Testing
- Simultaneous Resection
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- Hamilton Health Sciences Corporation
Colorectal Cancer
Shared Decision-making and Colorectal Cancer Screening
Conduct a feasibility pilot RCT of a newly developed colorectal cancer screening (CRC) decision aid (DA) including 66 LHL adults 76-85 years recruited from community health centers.
- Trial name
- NCT04748380
- Testing
- CRC decision aid pamphlet, Home Safety Pamphlet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer
A Study of Xeloda (Capecitabine) in Combination With Oxaliplatin in Patients With Metastatic Colorectal Cancer.
This single arm study will investigate possible pharmacokinetic interactions between Xeloda and oxaliplatin, and assess whether the pharmacokinetics of Xeloda and/or oxaliplatin is influenced by the addition of Avastin.
- Trial name
- NCT00353262
- Testing
- Avastin, Oxaliplatin, capecitabine [Xeloda]
- Where
- 3 sites in Canada
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Colorectal Cancer, Adhesion
Mechanical Ileus in the Era of Minimally Invasive Colorectal Surgery
The present study was to investigate if the incidence, patterns and surgical outcomes of mechanical ileus have changed in the era of minimally invasive surgery (MIS).
- Trial name
- NCT05999162
- Testing
- Minimally invasive surgery
- Where
- Taiwan
- Volunteers
- 1,544 people
- Sponsor
- National Taiwan University Hospital
Colorectal Neoplasms
Effects of Yoga on Cognitive and Immune Function in Colorectal Cancer
The purpose of this study is to determine if individuals with colorectal cancer enjoy yoga and to begin to assess whether yoga is effective in improving attention and immune function in individuals with colorectal cancer compared…
- Trial name
- NCT02564835
- Testing
- Yoga, Physical Activity
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Michigan
Colo-rectal Cancer
Development Study of Check-Cap Imaging System in Healthy Volunteers
To evaluate the performance of Check-Cap Imaging System in healthy volunteers in a variety of operating scenarios. The Back recorder unit is the primary module for evaluation The participants DO NOT ingest a capsule and the…
- Trial name
- NCT03989180
- Testing
- C-Scan System
- Where
- Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Colorectal Cancer, Squamous Cell Carcinoma of the Head and Neck
Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors
This is a Phase I multicenter, open label, nonrandomized study of enadenotucirev administered in combination with nivolumab in subjects with metastatic or advanced epithelial tumors (with focus on CRC, SCCHN, escalation phase)…
- Conditions
- Colorectal Cancer, Squamous Cell Carcinoma of the Head and Neck, Epithelial Tumor
- Trial name
- SPICE (NCT02636036)
- Testing
- enadenotucirev, nivolumab
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Akamis Bio
Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic
Predictive Model For Anastomotic Leakage After Colorectal Cancer Surgery
This pilot study aimed to develop a simplified early postoperative model for AL risk stratification using readily available clinical and laboratory variables.
- Conditions
- Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic, Surgery Complications
- Trial name
- Doesn't exist (NCT07709923)
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Breast Cancer, Colorectal Cancer
Michigan Genetic Hereditary Testing (MiGHT)
The primary purpose of this study is to compare three interventions, two experimental and one standard of care (usual care), to see if the experimental interventions will increase the likelihood of a participant obtaining…
- Conditions
- Breast Cancer, Colorectal Cancer, Ovarian Cancer, Prostate Cancer
- Trial name
- MiGHT (NCT05162846)
- Testing
- Publicly available genetic testing resources, Virtual genetics navigator, Motivational interviewing (MI)
- Where
- United States
- Volunteers
- 793 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Colorectal Cancer
RCT of Air Insufflation Versus Water Infusion Colonoscopy by Supervised Trainees
Our aim is to perform a randomized-controlled trial comparing air insufflation sedated colonoscopy (conventional method) vs. water infusion sedated colonoscopy (study method) by supervised trainees.
- Trial name
- NCT00841282
- Testing
- Colonoscopy for colorectal cancer screening, Water Infusion Colonoscopy, Air insufflation colonoscopy
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- East Bay Institute for Research and Education
Colorectal Cancer
PRESEPT Study: Evaluation of SEPT9 Biomarker Performance for Colorectal Cancer Screening
The purpose of this study is to collect blood specimens and clinical data from screening guideline eligible individuals designated by their physician to receive a screening colonoscopy, and to evaluate the performance of a…
- Trial name
- PRESEPT (NCT00855348)
- Testing
- All eligible subjects will provide blood for SEPT9 biomarker testing
- Where
- 23 sites in United States, Germany
- Volunteers
- 7,929 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Colorectal Cancer, Colon Cancer Liver Metastasis
Diffusion-Weighted MRI for Liver Metastasis
The DREAM study will assess the diagnostic accuracy of diffusion-weighted MRI in combination with other imaging modalities (multiparametric MRI and CT Scan) in determining the true status of disappearing liver metastasis (DLM)…
- Conditions
- Colorectal Cancer, Colon Cancer Liver Metastasis, Malignant Neoplasm of Rectum Metastatic to Liver
- Trial name
- DREAM (NCT02781935)
- Testing
- DW-MRI
- Where
- 21 sites in United States, Austria and 3 more
- Volunteers
- 233 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colon Cancer, Rectum Cancer
The Value of Laparoscopic Ultrasound in Patients Undergoing Laparoscopic Resection for Cancer of the Colon or Rectum
The following project deals with a Danish multicenter trial that evaluates the value of Laparoscopic Ultrasound examination (LUS) in laparoscopic surgery for colon and rectum cancer (CRC).
- Conditions
- Colon Cancer, Rectum Cancer, Liver Metastases
- Trial name
- NCT02079389
- Testing
- Lap+Lus
- Where
- 4 sites in Denmark
- Volunteers
- 280 people
- Sponsor
- Odense University Hospital
Rectal Cancer Patients
Impact Of Metformin In Rectal Cancer Patients
Design: Prospective, randomized controlled clinical trial Setting: at Minia University Hospital and Minia Oncology Institute. Condition: Colorectal cancer.
- Trial name
- NCT06728982
- Testing
- Metformin
- Where
- 2 sites in Egypt
- Volunteers
- 85 people
- Sponsor
- Minia University
Colorectal Cancer
Efficacy and Safety Study of Imprime PGG With Cetuximab in Subjects With Stage IV KRAS-Mutated Colorectal Cancer
Study BT-CL-PGG-CRC0821 is a Phase 2, open-label, multicenter, efficacy and safety study. It will be conducted using a two-stage design with the intention of determining the initial efficacy of Imprime PGG in combination with a…
- Trial name
- NCT00912327
- Testing
- Imprime PGG
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- HiberCell, Inc.
Colorectal Cancer
A Study of FOLFIRI Plus OMP-21M18 as 1st or 2nd-line Treatment in Subjects With Metastatic Colorectal Cancer
The purpose of this study is to test the safety and determine the optimal dose of a new drug, OMP-21M18, when given in combination with FOLFIRI, a standard drug treatment for advanced colorectal cancer.
- Trial name
- NCT01189942
- Testing
- OMP-21M18
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 18 people
- Sponsor
- OncoMed Pharmaceuticals, Inc.
Colorectal Cancer, Colorectal Neoplasms
Feasibility Study of a 4 Stage Bowel Obstruction Cancer Diet
Bowel obstruction is a common complication in patients with ovarian, peritoneal and bowel cancer due to a mass or spread of disease, causing narrowing to the gut, as these cancers can grow on the bowel surface.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma, Colorectal Adenocarcinoma
- Trial name
- BOUNCED (NCT04898842)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Non Small Cell Lung Cancer Squamous (NSCLC-Sq), Head and Neck Squamous Cell Carcinoma (HNSCC)
A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors
To assess safety and tolerability, describe the dose-limiting toxicities, assess the preliminary antitumor activity, determine the maximum tolerated dose (MTD) or the highest protocol-defined dose (maximum administered dose) in…
- Conditions
- Non Small Cell Lung Cancer Squamous (NSCLC-Sq), Head and Neck Squamous Cell Carcinoma (HNSCC), Small Cell Lung Cancer (SCLC), Pancreatic Ductal Adenocarcinoma (PDAC)
- Trial name
- NCT03811652
- Testing
- MEDI7247
- Where
- 3 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- MedImmune LLC
Colorectal Neoplasms
Nintedanib (BIBF 1120) vs Placebo in Refractory Metastatic Colorectal Cancer (LUME-Colon 1)
The objective of this Phase III study is to evaluate the efficacy of nintedanib in patients with metastatic colorectal cancer (mCRC) after failure of previous treatment with standard chemotherapy and biological agents.
- Trial name
- NCT02149108
- Testing
- Nintedanib (BIBF 1120), BSC
- Where
- 129 sites in United States, Argentina and 23 more
- Volunteers
- 768 people
- Sponsor
- Boehringer Ingelheim
Colorectal Cancer
A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC)
This randomized, multi-center, active-controlled, open-label, parallel-group study will investigate the efficacy and safety of biomarker-driven maintenance treatment for first-line mCRC.
- Trial name
- MODUL (NCT02291289)
- Testing
- Cetuximab, FOLFOX induction regimen, Fluoropyrimidine (5-FU/LV or capecitabine)
- Where
- 154 sites in Argentina, Belgium and 21 more
- Volunteers
- 1,044 people
- Sponsor
- Hoffmann-La Roche
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